Necessary role of phosphatidylinositol 3-kinase in transforming growth factor β-mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts

Arthritis and Rheumatism

Volumn 46, Issue 6, 2002, Pages 1504-1511

  Kim, Giok ^a   Jun, Jae Bum ^a   Elkon, Keith B ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTHRITIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIUM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; ARTHRITIS, RHEUMATOID; CELL DIVISION; CELLS, CULTURED; FIBROBLASTS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SYNOVIAL MEMBRANE; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036271952     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.10314     Document Type: Article

References (52)

1. TGF-beta signal transduction
2. Transforming growth factor-beta and cellular immune responses in synovial fluids
3. Enhanced expression of transforming growth factor-beta s and transforming growth factor-beta type II receptor in the synovial tissues of patients with rheumatoid arthritis
4. Increased synovial expression of transforming growth factor (TGF)-beta receptor endoglin and TGF-beta 1 in rheumatoid arthritis: Possible interactions in the pathogenesis of the disease
5. Dynamic expression of transforming growth factor-betas (TGF-beta) and their type I and type II receptors in the synovial tissue of arthritic rats
6. Regulation of immune responses by TGF-beta
7. Transforming growth factor production by chemically transformed cells
8. New class of transforming growth factors potentiated by epidermal growth factor: Isolation from non-neoplastic tissues
9. Invasive fibroblast-like synoviocytes in rheumatoid arthritis: Passive responders or transformed aggressors?
10. Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells
11. Interaction of smad3 with a proximal smad-binding element of the human alpha2(I) procollagen gene promoter required for transcriptional activation by TGF-beta
12. Smad-dependent transcriptional activation of human type VII collagen gene (COL7A1) promoter by transforming growth factor-beta
13. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
14. TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development
15. A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3
16. TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase
17. FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b
18. CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway
19. The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations
20. Transforming growth factor-beta-mediated apoptosis in the Ramos B-lymphoma cell line is accompanied by caspase activation and Bcl-XL downregulation
21. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
22. Characterization of transforming growth factor-beta 1 induced apoptosis in normal human B cells and lymphoma B cell lines
23. Cyclin A down-regulation in TGFbeta1-arrested follicular lymphoma cells
24. The multiple roles of PTEN in tumor suppression
25. Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration
26. The Akt kinase: Molecular determinants of oncogenicity
27. Role of phosphatidylinositol-3-kinase in insulin receptor signaling: Studies with inhibitor, LY294002
28. A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide
29. Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats: Studies on secretion by synovial fibroblast-like cells and immunohistologic localization
30. Keloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-beta1 can abrogate this resistance
31. Hepatocyte growth factor promotes cell survival from fas-mediated cell death in hepatocellular carcinoma cells via Akt activation and fas-death-inducing signaling complex suppression
32. Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP)
33. Impaired Fas response and autoimmunity in Pten+/- mice
34. Cellular survival: A play in three Akts
35. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
36. Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells
37. The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB
38. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
39. Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: Two cellular mechanisms explain joint destruction?
40. Role of cytokines in rheumatoid arthritis
41. Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis
42. Inhibition of Fas antigen-mediated apoptosis of rheumatoid synovial cells in vitro by transforming growth factor β1
43. Rheumatoid arthritis synovial macrophages express the Fas-associated death domain-like interleukin-1β-converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosis
44. Signalling through the lipid products of phosphoinositide-3-OH kinase
45. Role of apoptosis and transforming growth factor β1 in fibroblast selection and activation in systemic sclerosis
46. SARA a FYVE domain protein that recruits Smad2 to the TGFβ receptor
47. Jun N-terminal kinase in rheumatoid arthritis
48. Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase in synovial tissue and cells in rheumatoid arthritis
49. Genetic events and the role of TGF beta in epithelial tumour progression
50. Overexpression of Smad2 and colocalization with TGF-β1 in human pancreatic cancer
51. Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1
52. Transforming growth factor betal (TGF-betal) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling