Potential anticarcinogenic action of melatonin and other antioxidants mediated by antioxidative mechanisms

Neuroendocrinology Letters

Volumn 23, Issue SUPPL. 1, 2002, Pages 39-44

  Karbownik, Malgorzata ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Antioxidants; Carcinogens; DNA; Melatonin; Membranes cancer initiation; Oxidative stress; Protection

Indexed keywords

ALPHA TOCOPHEROL; AMINOLEVULINIC ACID; ANTIOXIDANT; ASCORBIC ACID; BROMINE; CADMIUM; CHROMIUM; DEFEROXAMINE; DNA; ESTRADIOL; GLUTATHIONE; INDOLE DERIVATIVE; INDOLEAMINE; IRON; MELATONIN; MERCURY; NITRILOTRIACETATE IRON; NITROALKANE; PHENYLHYDRAZINE; PHOSPHINE; SAFROLE; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; CANCER RISK; CELL DAMAGE; CELL MEMBRANE; CELL PROTECTION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; IONIZING RADIATION; MACROMOLECULE; MOUSE; NONHUMAN; OXIDATIVE STRESS; RAT; REVIEW;

EID: 0036265077     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (80)

1. Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
2. Strategies of antioxidant defense
3. Role of oxygen free radicals in cancer development
4. The role of oxidative stress in chemical carcinogenesis
5. Biomarkers of free radical damage applications in experimental animals and in humans
6. The role of 8-hydroxydeoxyguanosine in carcinogenesis
7. Oxyradicals and DNA damage
8. Genotoxic lipid peroxidation products: Their DNA damaging properties and role in formation of endogenous DNA adducts
9. Protein oxidation and aging
10. Oxidative damage in the central nervous system: Protection by melatonin
11. Oxidative damage to nuclear DNA: Amelioration by melatonin
12. Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo
13. Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation
14. Cholelithiasis, oxidative stress and melatonin
15. Melatonin: An antioxidant at physiological concentrations
16. Melatonin, mitochondria and cellular bioenergetics
17. Pineal gland, melatonin and cancer
18. Oncostatic action of melatonin: Facts and question marks
19. Melatonin in clinical oncology
20. Oncostatic activity of pineal neuroendocrine treatment with the pineal indoles melatonin and 5-methoxytryptamine in untreatable metastatic cancer patients progressing on melatonin alone
21. Polyunsaturated fatty acids, melatonin, and cancer prevention
22. Anti-angiogenic activity of melatonin in advanced cancer patients
23. Distribution of melatonin in mammalian tissues: The relative importance of cytosolic versus nuclear localization
24. Evidence for melatonin synthesis in mouse and human bone marrow cells
25. Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat
26. Melatonin: A potent, endogenous hydroxyl radical scavenger
27. Potent neuroprotective properties against the Alzheimer β-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid
28. Melatonin protects against oxidative stress caused by δ-aminolevulinic acid: Implication for cancer reduction
29. Vitamin C reduces the incidence and severity of renal tumors induced by estradiol or diethylstilbestrol
30. The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers
31. Hydroxyl radicals and DNA base damage
32. Mechanism of DNA oxidation
33. Body iron stores and the risk of cancer
34. Relative efficacies of indole antioxidants in reducing autoxidation and iron-induced lipid peroxidation in testes: Implications for cancer initiation
35. Individual and synergistic antioxidative actions of melatonin: Studies with vitamin E, vitamin C, glutathione and desferrioxamine (desferoxamine) in rat liver homogenates
36. Risk of testicular cancer in subfertile men: Case-control study
37. Melatonin reduces phenylhydrazine-induced oxidative damage to cellular membranes: Evidence for the involvement of iron
38. Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation
39. Melatonin enhances tamoxifen's ability to prevent the reduction in microsomal membrane fluidity induced by lipid peroxidation
40. N-acetylserotonin suppresses hepatic microsomal membrane rigidity associated with lipid peroxidation
41. Role of pinoline and melatonin in stabilizing hepatic microsomal membranes against oxidative stress
42. 5-Methoxytryptophol preserves hepatic microsomal membrane fluidity during oxidative stress
43. Indole-3-propionic acid, a melatonin-related molecule, protects hepatic microsomal membranes from iron-induced oxidative damage: Relevance to cancer reduction
44. The porphyries
45. Primary liver cancer, other malignancies, and mortality risks following porphyria: A cohort study in Denmark and Sweden
46. Melatonin reduces rat hepatic macromolecular damage due to oxidative stress caused by δ-aminolevulinic acid
47. Renal toxicity of the carcinogen δ-aminolevulinic acid: Antioxidant effects of melatonin
48. Melatonin reduces the oxidation of nuclear DNA and membrane lipids induced by the carcinogen δ-aminolevulinic acid
49. DNA-damaging activity in vivo and bacterial mutagenicity of sixteen hydrazine derivatives as related quantitatively to their carcinogenicity
50. Release of free, redox-active iron in the liver and DNA oxidative damage following phenylhydrazine intoxication
51. Enzymatic processing of radiation-induced free radical damage in DNA
52. Protective effects of melatonin against oxidation of guanine bases in DNA and decreased microsomal membrane fluidity in rat liver induced by whole body ionizing radiation
53. Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts
54. Metal carcinogenesis: Mechanistic implications
55. Potent protective effect of melatonin on chromium (VI)-induced DNA single-strand breaks, cytotoxicity, and lipid peroxidation in primary cultures of rat hepatocytes
56. 2: Protection by melatonin and related molecules
57. Chromium(III)-induced 8-hydroxydeoxyguanosine in DNA and its reduction by antioxidants: Comparative effects of melatonin, ascorbate, and vitamin E
58. Carcinogen-induced, free radical-mediated reduction in microsomal membrane fluidity: Reversal by indole-3-propionic acid
59. Oxidative mechanisms in the toxicity of chromium and cadmium ions
60. Induction of lipid peroxidation in hamster organs by the carcinogen cadmium: Amelioration by melatonin
61. Toxicity and carcinogenicity of potassium bromate - A new renal carcinogen
62. 3
63. Mercury induces cell cytotoxicity and oxidative stress and increases beta amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells
64. Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate
65. Inhibitory effects of melatonin on ferric nitriloriacetate-induced lipid peroxidation and oxidative DNA damage in the rat kidney
66. Safrole, Isosafrole, and Dihydrosafrole
67. The pineal hormone melatonin inhibits DNA-adducts formation induced by the chemical carcinogen safrole in vivo
68. Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole
69. Assay of 1-nitropropane, 2-nitropropane, 1-azoxypropane and 2-azoxypropane for carcinogenicity by gavage in Sprague-Dawley rats
70. Solvents in pesticides
71. 2-Nitropropane-induced lipid peroxidation: Antitoxic effects of melatonin
72. Determination of genotoxic and other effects in mice following short term repeated-dose and subchronic inhalation exposure to phosphine
73. Human genotoxicity: Pesticide applicators and phosphine
74. Phosphine-induced oxidative damage in rats: Attenuation by melatonin
75. Is estradiol a genotoxic mutagenic carcinogen?
76. Estrogen, DNA damage and mutations
77. Melatonin attenuates estradiol-induced oxidative damage to DNA: Relevance for cancer prevention
78. Comparison of the protective effect of melatonin with other antioxidants in the hamster kidney model of estradiol-induced DNA damage
79. Physiological levels of melatonin contribute to the antioxidant capacity of human serum
80. Effects of melatonin treatment in septic newborns