Peptide targeting and delivery across the blood-brain barrier utilizing synthetic triglyceride esters: Design, synthesis, and bioactivity

Bioconjugate Chemistry

Volumn 8, Issue 3, 1997, Pages 434-441

  Patel, Dinesh ^a   McKinley, Brian D ^a   Davis, Thomas P ^b   Porreca, Frank ^b   Yamamura, Henry I ^b   Hruby, Victor J ^a  

^a University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; BLOOD;

ACTIVE PEPTIDES; BIOACTIVE PEPTIDES; BLOOD-BRAIN BARRIER; DESIGN STRATEGIES; DESIGN SYNTHESIS; LOCALISED; MEMBRANE-BOUND ENZYMES; PEPTIDE CARRIER; PRODRUGS; TARGETING SYSTEMS;

PEPTIDES;

EID: 0031149919     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc970027g     Document Type: Article

References (21)

1. Hruby, V. J., and Gehrig, C. C. (1989) Recent Developments in the Design of Receptor Specific Opioid-Peptides. Med. Res. Rev. 9, 343-401.
2. Knapp, R. J., Vaughn, L. K., and Yamamura, H. I. (1995) Selective Ligands for μ and δ Opioid Receptors. The Pharmacology of Opioid Peptides (L. F. Tseng, Ed.) pp 1-27, Harwood Academic Publishers, New York.
3. Schiller, P. W. (1993) Development of Receptor-Selective Opioid Peptide Analogs as Pharmacological Tools and As Potential Drugs. Handbook of Experimental Pharmacology, Vol. 104/1(Opioids I), pp 681-710, Springer-Verlag, Berlin.
4. Bickel, U., Yoshiwawa, T., Landaw, E. M., Faull, K. F., and Pardridge, W. M. (1993) Pharmacological Effects In Vivo in Brain by Vector-Mediated Peptide Drug Delivery. Proc. Natl. Acad. Sci. U.S.A. 90, 2618-2622.
5. Bungaard, H. (1992) Prodrugs as a Means to Improve the Delivery of Peptide Drugs. Adv. Drug Delivery Rev. 8, 1-38.
6. Kreuter, J., Alyautdin, R. N., Kharkevich, D. A., and Ivanov, A. A. (1995) Passage of Peptides Through the Blood-Brain-Barrier with Colloidal Polymer Particles (Nanoparticles). Brain Res. 674, 171-174.
7. Fukuta, M., Okada, H., Iinuma, S., Yanai, S., and Toguchi, H. (1994) Insulin Fragments as a Carrier for Peptide Delivery Across the Blood-Brain-Barrier. Pharm. Res. 11, 1681-1688.
8. Sakata, A., Tamai, I., Kawazu, K., Deguchi, Y., Ohnishi, T., Saheki, A., and Tsuji, A. (1994) In-Vivo Evidence for Atp-Dependent and P-Glycoprotein-Mediated Transport of Cyclosporine-A at the Blood-Brain-Barrier. Biochem. Pharmacol. 48 (10), 1989-1992.
9. Pardridge, W. M. (1991) Peptide Drug Delivery to the Brain, Raven Press, New York.
10. Risau, W., Dingler, A., Albrecht, U., Dehouck, M.-P., and Cecchelli, R. (1992) Blood-Brain-Barrier Pericytes are the Main Source of Gamma-Glutamyl-Transpeptidase Activity in Brain Capillaries. J. Neurochem. 58, 667-672.
11. Vorbodt, A. W., Lossinsky, A. S., and Wisniewski, H. M. (1986) Characterization of Endothelial-Cell Transport in the Developing Mouse Blood-Brain-Barrier. Dev. Neurosci. 8, 1-13.
12. Shook, J. E., Pelton, J. T., Wire, W. S., Hirning, L. D., Hruby, V. J., and Burks, T. F. (1987) Pharmacologic Evaluation of a Cyclic Somatostatin Analog with Antagonist Activity at Mu Opioid Receptors In Vitro. J. Pharmacol. Exp. Ther. 240, 772-777.
13. Statistical Consultants. (1986) Am. Stat. 40, 52-60.
14. 3H]CTOP). A Potent and Highly Selective Peptide for Mu-Opioid Receptors in Rat-Brain. J. Pharmacol. Exp. Ther. 248, 73-80.
15. 5]Enkephalin. Life Sci. 45, 1001-1008.
16. Horan, P., Mattia, A., Bilsky, E. J., Weber, S., Davis, T. P., Yamamura, H. I., Malatynsk, E., Appleyard, S. M., Slaninova, J., Misicka, A., Lipkowski, A. W., Hruby, V. J., and Porreca, F. (1993) Antinociceptive Profile of Biphalin, A Dimeric Enkephalin Analog. J. Pharmacol. Exp. Ther. 265, 1446-1454.
17. Heyman, J. S., Mulvaney, S. A., Mosberg, H. I., and Porreca, F. (1987) Opioid δ Receptor Involvement in Supraspinal and Spinal Antinociception in Mice. Brain Res. 420, 100-108.
18. Rink, H. (1987) Solid-Phase Synthesis of Protected Peptide-Fragments Using a Trialkoxy-Diphenyl-Methylester Resin. Tetrahedron Lett. 28, 3787-3791.
19. Erspamer, V., Melchiorri, P., Falconieri-Erspamer, G., Negri, L., Corsi, R., Sererini, C., Barra, D., Simmaco, M., and Kriel, G. (1989) Deltorphins: A Family of Naturally Occurring Peptides With High Affinity and Selectivity for δ Opioid Binding Sites. Proc. Natl. Acad. Sci. U.S.A. 86, 5188-5192.
20. 2)-A Potent and Fully Specific Agonist for the Delta-Opioid Receptor. Mol. Pharmacol. 35, 774-779.
21. 5]Enkephalin In the MuOpioid Receptor Deficient CxBk Mouse. Pharm. Res. 8, 1-8.