Yersinia enterocolitica can deliver Yop proteins into a wide range of cell types: Development of a delivery system for heterologous proteins

European Journal of Cell Biology

Volumn 79, Issue 10, 2000, Pages 659-671

  Boyd, Aoife P ^a,c   Grosdent, Nadine ^a   Tötemeyer, Sabine ^a,d   Geuijen, Cecilia ^a,e   Bleves, Sophie ^a   Iriarte, Maite ^a,f   Lambermont, Isabelle ^a   Octave, Jean Noël ^b   Cornelis, Guy R ^a,g  

^a DE DUVE INSTITUTE   (Belgium)

^b UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

^c CISTEM Biotechnologies GmbH   (Austria)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e NETHERLANDS CANCER INSTITUTE   (Netherlands)

^f UNIVERSITY OF NAVARRA   (Spain)

^g UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Protein delivery; Yersinia; Yop translocation

Indexed keywords

ADHESIN; BACTERIAL PROTEIN; DIPHTHERIA TOXIN; INVASIN; VIRULENCE FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BACTERIAL MUTATION; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; CELL ADHESION; CELL SPECIFICITY; CELL STRAIN; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; EUKARYOTE; EXPRESSION VECTOR; HUMAN; HUMAN CELL; INSECT; INTRACELLULAR TRANSPORT; MACROPHAGE; MONKEY; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; YERSINIA ENTEROCOLITICA;

EID: 0033754201     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-9335-00098     Document Type: Article

References (61)

1. Mutational analysis of the Yersinia enterocolitica virC operon: Characterization of yscE, F, G, I, J, K required for Yop secretion and yscH encoding YopR
2. Yersinia pseudotuberculosis-induced calcium signaling in neutrophils is blocked by the virulence effector YopH
3. Identification of p130(Cas) as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions
4. Identification of an amino-terminal substrate-binding domain in the Yersinia tyrosine phosphatase that is required for efficient recognition of focal adhesion targets
5. Role of YopP in suppression of tumor necrosis factor alpha release by macrophages during Yersinia infection
6. Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y. enterocolitica is internalized inside the cytosol of PU5-1.8 macrophages by the YopB, D, N delivery apparatus
7. Competition between the Yops of Yersinia enterocolitica for delivery into eukaryotic cells: Role of the SycE chaperone binding domain of YopE
8. Heparin interferes with translocation of Yop proteins into HeLa cells and binds to LcrG, a regulatory component of the Yersinia Yop apparatus
9. The role of local actin instability in axon formation
10. Interaction with a lipid membrane: A key step in bacterial toxins virulence
11. Identification of five MAGE-A1 epitopes recognized by cytolytic T lymphocytes obtained by in vitro stimulation with dendritic cells transduced with MAGE-A1
12. The pYV plasmid of Yersinia encodes a lipoprotein, YlpA, related to TraT
13. Transcription of the yop regulon from Y. enterocolitica requires trans acting pYV and chromosomal genes
14. The virulence plasmid of Yersinia, an antihost genome
15. A MAGE-A4 peptide presented by HLA-A2 is recognized by cytolytic T lymphocytes
16. Nonrestricted differential intoxication of cells by pertussis toxin
17. Binding to collagen by Yersinia enterocolitica and Yersinia pseudotuberculosis: Evidence for yopA-mediated and chromosomally encoded mechanisms
18. Virulence role of V antigen of Yersinia pestis at the bacterial surface
19. The surface-located YopN protein is involved in calcium signal transduction in Yersinia pseudotuberculosis
20. Diphtheria toxin fusion proteins
21. The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membrane
22. The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact dependent membrane disrupting activity
23. YopH dephosphorylates Cas and Fyn-binding protein in macrophages
24. YopK of Yersinia pseudotuberculosis controls translocation of Yop effectors across the eukaryotic cell membrane
25. YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells
26. TyeA, a protein involved in control of Yop release and in translocation of Yersinia Yop effectors
27. Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells
28. Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells
29. Pathogenesis of shigella diarrhea. XI. Isolation of a shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide
30. A wide-host-range suicide vector for improving reverse genetics in gram-negative bacteria: Inactivation of the blaA gene of Yersinia enterocolitica
31. DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis
32. Expression of plasminogen activator pla of Yersinia pestis enhances bacterial attachment to the mammalian matrix
33. Type III machines of pathogenic yersiniae secrete virulence factors into the extracellular milieu
34. Secretion of hybrid proteins by the Yersinia Yop export system
35. YopP, a novel Yersinia effector protein, is delivered into macrophages to induce apoptosis
36. Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death
37. Translocation of diphtheria toxin A-fragment to the cytosol
38. Insertion of a Yop translocation pore into the macrophage plasma membrane by Yersinia enterocolitica: Requirement for translocators YopB and YopD, but not LcrG
39. The pH 6 antigen of Yersinia pestis binds to β1-linked galoctosyl residues in glycosphingolipids
40. YscP of Yersinia pestis is a secreted component of the Yop secretion system
41. Cell-surface-bound Yersinia translocate the protein tyrosine phosphatase YopH by a polarized mechanism into the target cell
42. The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130(Cas) and FAK, and the associated accumulation of these proteins in peripheral focal adhesions
43. Modulation of virulence factor expression by pathogen target cell contact
44. The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation
45. Increased virulence of Yersinia pseudotuberculosis by two independent mutations
46. The cytotoxic protein YopE of Yersinia obstructs the primary host defence
47. Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption
48. Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells
49. Toxin-induced cell lysis: Protection by 3-methyladenine and cycloheximide
50. An improved version of suicide vector pKNG101 for gene replacement in Gram-negative bacteria
51. The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD
52. LcrG controls internalization of Yersinia Yop effector proteins into eukaryotic cells
53. Invasin production by Yersinia pestis is abolished by insertion of an IS200-like element within the inv gene
54. Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells
55. Yersinia enterocolitica type III secretion-translocation system: Channel formation by secreted Yops
56. Adhesion protein YadA of Yersinia species mediates binding of bacteria to fibronectin
57. GAP activity if the Yersinia YopE cytotoxin specifically targets the Rho pathway: A mechanism for disruption of actin structure
58. Integrin signaling: Tyrosine phosphorylation events in focal adhesions
59. Suppression of T and B lymphocyte activation by a Yersinia pseudotuberculosis virulence factor, YopH
60. The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding RhoA