A bacterial type III secretion system inhibits actin polymerization to prevent pore formation in host cell membranes

EMBO Journal

Volumn 20, Issue 19, 2001, Pages 5373-5382

  Viboud, G I ^a   Bliska, J B ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Actin; Pore; Type III secretion; Yersinia; YopE

Indexed keywords

ACTIN; BACTERIAL PROTEIN; F ACTIN; GUANOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; YERSINIA OUTER PROTEIN E; YOP PROTEIN;

ARTICLE; ASSAY; BACTERIAL VIRULENCE; CELL MEMBRANE; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; YERSINIA PSEUDOTUBERCULOSIS;

ACTINS; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CYSTEINE ENDOPEPTIDASES; CYTOTOXINS; HELA CELLS; HUMANS; ION CHANNELS; L-LACTATE DEHYDROGENASE; RAC1 GTP-BINDING PROTEIN; RHOA GTP-BINDING PROTEIN; YERSINIA PSEUDOTUBERCULOSIS;

EID: 0035477848     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.19.5373     Document Type: Article

References (41)

1. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages
2. Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions
3. The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence
4. Yop effectors of Yersinia spp. and actin rearrangements
5. Inhibition of the Fc receptor-mediated oxidative burst in macrophages by the Yersinia pseudotuberculosis tyrosine phosphatase
6. The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes
7. Temperature-inducible outer membrane protein of Yersinia pseudotuberculosis and Yersinia enterocolitica is associated with the virulence plasmid
8. The virulence plasmid of Yersinia, an antihost genome
9. A requirement for phosphatidylinositol 3-kinase in pseudopod extension
10. LcrV of Yersinia pestis enters infected eukaryotic cells by a virulence plasmid-independent mechanism
11. YopD of Yersinia pseudotuberculosis is translocated into the cytosol of HeLa epithelial cells: Evidence of a structural domain necessary for translocation
12. A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion
13. Cross-talk between bacterial pathogens and their host cells
14. Striking a balance: Modulation of the actin cytoskeleton by Salmonella
15. The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity
16. Rho GTPases and the actin cytoskeleton
17. Polymerization of a single protein of the pathogen Yersinia enterocolitica into needles punctures eukaryotic cells
18. LcrV is a channel size-determining component of the Yop effector translocon of Yersinia
19. Type III protein secretion systems in bacterial pathogens of animals and plants
20. YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells
21. Multiple β 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells
22. Binding and internalization of microorganisms by integrin receptors
23. Evidence for pore-forming ability by Legionella pneumophila
24. Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion system
25. The Yersinia Yops inhibit invasion of Listeria, Shigella and Edwardsiella but not Salmonella into epithelial cells
26. Insertion of a Yop translocation pore into the macrophage plasma membrane by Yersinia enterocolitica: Requirement for translocators YopB and YopD, but not LcrG
27. YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNF-α production and downregulation of the MAP kinases p38 and JNK
28. YopJ of Yersinia spp. is sufficient to cause downregulation of multiple mitogen-activated protein kinases in eukaryotic cells
29. Cell-surface-bound Yersinia translocate the protein tyrosine phosphatase YopH by a polarized mechanism into the target cell
30. The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation
31. The cytotoxic protein YopE of Yersinia obstructs the primary host defence
32. Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption
33. Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells
34. The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD
35. Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells
36. Supramolecular structure of the Shigella type III secretion machinery: The needle part is changeable in length and essential for delivery of effectors
37. Yersinia enterocolitica type III secretion-translocation system: Channel formation by secreted Yops
38. IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells
39. Rho GTPases and signaling networks
40. GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: A mechanism for disruption of actin microfilament structure
41. The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoA