Diacylglycerol kinase α activity promotes survival of CD4+ 8+ double positive cells during thymocyte development

Immunology

Volumn 105, Issue 4, 2002, Pages 391-398

  Outram, Susan V ^a   Crompton, Tessa ^a   Merida, Isabel ^b   Varas, Alberto ^a   Martinez A, Carlos ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [4 (4,4' DIFLUOROBENZHYDRYLIDENE)PIPERIDINO]ETHYL] 2,3 DIHYDRO 2 THIOXO 4(1H) QUINAZOLINONE; DIACYLGLYCEROL KINASE; DIACYLGLYCEROL KINASE ALPHA; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE LCK; PROTEIN TYROSINE KINASE; RNA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL MATURATION; CELL POPULATION; CELL SURVIVAL; CELL SUSPENSION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FETUS; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMOCYTE; TRANSGENIC MOUSE;

ANIMALS; BCL-X PROTEIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; DIACYLGLYCEROL KINASE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENES, BCL-2; ISOENZYMES; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINAZOLINES; QUINAZOLINONES; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0036228198     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2002.01385.x     Document Type: Article

References (42)

1. T cell receptor-mediated signs and signals governing T cell development
2. Signals involved in thymocyte positive and negative selection
3. Pleiotropic changes controlled by the pre-T-cell receptor
4. Cell-fate decisions in early T cell development: Regulation by cytokine receptors and the pre-TCR
5. Profound block in thymocyte development in mice lacking p56lck
6. Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation
7. Translocation of diacylglycerol kinase alpha to the nuclear matrix of rat thymocytes and peripheral T-lymphocytes
8. Molecular properties of enzymes involved in diacylglycerol and phosphatidate metabolism
9. Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides
10. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
11. Regulation of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae
12. Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet-derived growth factor mRNAs in cultured mesangial cells. Role of protein kinase C
13. Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins
14. The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras
15. A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids
16. Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases
17. Diacylglycerol kinase inhibition prevents IL-2-induced G1 to S transition through a phosphatidylinositol-3 kinase-independent mechanism
18. Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses
19. The role of endogenously formed diacylglycerol in the propagation and termination of platelet activation. A biochemical and functional analysis using the novel diacylglycerol kinase inhibitor, R59949
20. Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor-1 by low oxygen tension
21. Enhanced nuclear diacylglycerol kinase activity in response to a mitogenic stimulation of quiescent Swiss 3T3 cells with insulin-like growth factor I
22. A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus
23. Selectivity of the diacylglycerol kinase inhibitor 3-[2-(4-[bis-(4-fluorophenyl) methylene]-1-piperidinyl) ethyl]-2, 3-dihydro-2-thioxo-4 (1H) quinazolinone (R59949) among diacylglycerol kinase subtypes
24. Molecules in focus: Diacylglycerol kinase
25. Distinct roles of the interleukin-7 receptor alpha chain in fetal and adult thymocyte development revealed by analysis of interleukin-7 receptor alpha-deficient mice
26. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
27. Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon
28. Differential requirement for p56lck in fetal and adult thymopoiesis
29. Development in the thymus: It takes two to tango
30. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells
31. The Bcl-2 protein family: Arbiters of cell survival
32. Bcl-XL and Bcl-2 repress a common pathway of cell death
33. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
34. Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice
35. The GTPase Rho has a critical regulatory role in thymus development
36. Different functions of the GTPase Rho in prothymocytes and late pre-T cells
37. Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta
38. Diacylglycerol kinase epsilon, but not zeta, selectively removes polyunsaturated diacylglycerol, inducing altered protein kinase C distribution in vivo
39. Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: The requirement for Bcl-2 differs depending on the TCR/MHC affinity
40. A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells
41. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL
42. Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice