Selectivity of the diacylglycerol kinase inhibitor 3-{2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone (R59949) among diacylglycerol kinase subtypes

Biochemical Pharmacology

Volumn 59, Issue 7, 2000, Pages 763-772

  Jiang, Ying ^a   Sakane, Fumio ^b   Kanoh, Hideo ^b   Walsh, James P ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Calcium; Diacylglycerol; Phosphatidic acid; Phosphotransferases

Indexed keywords

3 [2 [4 (4,4' DIFLUOROBENZHYDRYLIDENE)PIPERIDINO]ETHYL] 2,3 DIHYDRO 2 THIOXO 4(1H) QUINAZOLINONE; 6 [2 [4 [(4 FLUOROPHENYL)PHENYLMETHYLENE] 1 PIPERIDYL]ETHYL] 7 METHYL 5H THIAZOLO[3,2 A]PYRIMIDIN 5 ONE; ADENOSINE TRIPHOSPHATE MAGNESIUM; DIACYLGLYCEROL KINASE; DIACYLGLYCEROL KINASE INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL STRAIN 3T3; CELL STRAIN COS1; DELETION MUTANT; ENZYME BINDING; ENZYME INHIBITION; ENZYME SPECIFICITY; IN VITRO STUDY; MICELLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBMANDIBULAR GLAND; SWINE; TESTIS; THYMUS; YEAST;

3T3 CELLS; ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CATALYTIC DOMAIN; COS CELLS; DIACYLGLYCEROL KINASE; ENZYME INHIBITORS; ISOENZYMES; MICE; PIPERIDINES; QUINAZOLINES; QUINAZOLINONES; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY;

EID: 0033954192     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00395-0     Document Type: Article

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