Diacylglycerol kinase inhibition prevents IL-2-induced G1 to S transition through a phosphatidylinositol-3 kinase-independent mechanism

Journal of Immunology

Volumn 163, Issue 2, 1999, Pages 708-714

  Flores, Ignacio ^a   Jones, David R ^a   Ciprés, Angel ^a   Díaz Flores, Ernesto ^a   Sanjuan, Miguel Angel ^a   Mérida, Isabel ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL KINASE; INTERLEUKIN 2; PHOSPHATIDIC ACID; PROTEIN BCL 2; PROTEIN BCL X; RAF PROTEIN;

ARTICLE; CELL CYCLE PHASE; CELL DIVISION; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; ONCOGENE C FOS; ONCOGENE C MYC; PRIORITY JOURNAL; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CULTURE MEDIA, SERUM-FREE; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; DIACYLGLYCEROL KINASE; ENZYME ACTIVATION; ENZYME INHIBITORS; G1 PHASE; GENE EXPRESSION REGULATION; INTERLEUKIN-2; INTERLEUKIN-4; MICE; MICROTUBULE-ASSOCIATED PROTEINS; PIPERIDINES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENES; QUINAZOLINES; QUINAZOLINONES; RETINOBLASTOMA PROTEIN; S PHASE; T-LYMPHOCYTES, CYTOTOXIC; TUMOR SUPPRESSOR PROTEINS;

EID: 0033565429     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Taniguchi, T., and Y. Minami. 1993. The IL2/IL2 receptor system: a current overview. Cell 73:5.
2. Smith, K. A. 1988. Interleukin-2: inception, impact and implications. Science 240:1169.
3. Leonard, W. J. 1994. The defective gene in X-linked severe combined immuno-deficiency encodes a shared interleukin receptor subunit: implication for cytokine pleiotropy and redundance. Curr. Opin. Immunol. 6:631.
4. Taniguchi, T. 1995. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251.
5. Miyazaki, T., A. Kawahara, H. Fujii, Y. Nakagawa, Y. Minami, Z. J. Liu, I. Oishi, O. Silvennoinen, B. Witthuhn, and J. Ihle. 1994. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266: 1045.
6. Nelson, B. H., J. D. Lord, and P. D. Greenberg. 1994. Cytoplasmic domains of the IL2R β and γ chain cytoplasmic domain are required for signaling. Nature 369:333.
7. Evans, G. A., M. A. Goldsmith, J. A. Johnston, W. Xu, S. R. Weiler, R. Erwin, O. M. Zack Howard, R. T. Abraham, J. J. O'Shea, W. C. Greene, and W. L. Farrar. 1995. Analysis of IL-2-dependent signal transduction through the Shc/Grb2 adapter pathway. J. Biol. Chem. 270:28858.
8. Flores, I., T. Casaseca, C. Martinez-A., H. Kanoh, and I. Merida. 1996. Phosphatidic acid generation through IL-2-induced or DGK activation is an essential step in IL-2-mediated lymphocyte proliferation. J. Biol. Chem. 271:10334.
9. Merida, I., E. Diez, and G. N. Gaulton. 1991. Interleukin 2 binding activates a tyrosine phosphorylated phosphatidylinositol-3 kinase. J. Immunol. 147:2202.
10. Merida, I., P. Williamson, K. Smith, and G. N. Gaulton. 1993. The role of diacylglycerol kinase activation and phosphatidate accumulation in interleukin-2-dependent lymphocyte proliferation. DNA Cell Biol. 12:473.
11. Miyazaki, T., Z. J. Liu, A. Kawahara, Y. Minami, K. Yamada, Y. Tsujimoto, E. L. Barsouimian, R. M. Perlmutter, and T. Taniguchi. 1995. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc and lck cooperate in hematopoietic cell proliferation. Cell 81:223.
12. Shibuya, H., M. Yoneyama, J. Ninomiya-Tsuji, K. Matsumoto, and T. Taniguchi. 1992. IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Cell 70:57.
13. Broome, H. E., C. M. Dargan, S. Krajewski, and J. Reed. 1995. Expression of Bcl-2, Bcl-x and Bax after T cell activation and IL2 withdrawal. J. Immunol. 155:2311.
14. Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323.
15. Flores, I., C. Martinez-A, Y. A. Hannun, and I. Merida. 1998. Dual role of ceramide in the control of apoptosis following IL-2 withdrawal. J. Immunol. 160:3528.
16. Matsushime, H., D. E. Quelle, S. A. Shurtleff, M. Shibuya, C. J. Sherr, and J. Y. Kato. 1994. D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14:2066.
17. 1 cyclin-dependent kinases. Genes Dev. 9:1149.
18. Matsuoka, M., J. Y. Kato, R. P. Fisher, D. O. Morgan, and C. J. Sherr. 1994. Activation of cyclin-dependent kinase 4 by mouse MO15-associated kinase. Mol. Cell. Biol. 14:7265.
19. Nourse, J., E. Firpo, W. M. Flanagan, S. Coats, K. Polyak, M. Lee, J. Massague, G. R. Crabtree, and J. M. Roberts, 1994. Interleukin-2-mediated elimination of the p27 kip1 cyclin dependent kinase inhibitor prevented by rapamycin. Nature 372:570.
20. Morice, W. G., G. Wiederrecht, G. J. Brunn, J. J. Siekierka, and R. T. Abraham. 1993. Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes. J. Biol. Chem. 268:22737.
21. Augustine, J. A., R. L. Sutor, and R. T. Abraham. 1991. Interleukin 2 and polyoma middle T antigen-induced modification of phosphatidylinositol-3-kinase activity in activated T lymphocytes. Mol. Cell. Biol. 11:4431.
22. Remillard, B., R. Petrillo, W. Maslinski, M. Tsudo, T. B. Stromm, L. Cantley, and L. Varticovski. 1991. Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase. J. Biol. Chem. 256:14167.
23. Brennan, P., J. W. Babbage, B. M. T. Burgering, B. Groner, K. Reif, and D. Cantrell. 1997. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 7:679.
24. Reif, K., B. M. T. Burgering, and D. A. Cantrell. 1997. Phosphatidylinositol 3 kinase links the interleukin-2 receptor to protein kinase B and p70S6 kinase. J. Biol. Chem. 272:14426.
25. Jones, D. R., I. Flores, E. Diaz, C. Martinez-A, and I. Merida. 1998. Interleukin-2 stimulates a late increase in phosphatidic acid production in the absence of phospholipase D activation. FEBS Lett. 432:23.
26. Sakane, F., and H. Kanoh. 1998. Molecules in focus: diacylglycerol kinase. Int. J. Biochem. Cell Biol. 29:1139.
27. Sakane, F., K. Yamada, H. Kanoh, C. Yokoyama, and T. Tanabe. 1990. Porcine diacylglycerol kinase sequence has zinc finger and E-F hand motifs. Nature 344:345.
28. 1 and S in CD3-stimulated primary human T cells. Mol. Cell. Biol. 91:2794.
29. Cano, E., M. A. Muñoz-Fernández, and M. Fresno. 1992. Regulation of interleukin-2 responses by phosphatidic acid. Eur. J. Immunol. 22:1883.
30. Mui, A. L., H. Wakao, T. Kinoshita, T. Kitamura, A. Miyajima. 1996. Suppression of interleukin-3-induced gene expression by a C-termial truncated Stat5: role of Stat5 in proliferation. EMBO J. 15:2425.
31. Castro, A., T. P. Sengupta, D. C. Ruiz, E. Yang, and L. B. Ivshkiv. 1999. IL-4 selectively inhibits IL-2-triggered Stat 5 activation, but not proliferation, in human T cells. J. Immunol. 162:1261.