Epilepsy as an example of neural plasticity

Neuroscientist

Volumn 8, Issue 2, 2002, Pages 154-173

  Scharfman, Helen E ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b HELEN HAYES HOSPITAL   (United States)

Author keywords

Dentate gyrus; Granule cell; Hippocampus; Neurogenesis; Neuropeptides; Neurotrophins; Seizures

Indexed keywords

4 AMINO 5 HEXYNOIC ACID; 4 AMINOBUTYRIC ACID; ALLYLGLYCINE; AMINOOXYACETIC ACID; BICUCULLINE; BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLINESTERASE INHIBITOR; GLUTAMIC ACID; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROPEPTIDE; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN 4; PILOCARPINE; TETANUS TOXIN;

ANIMAL MODEL; DENTATE GYRUS; EPILEPSY; GENE EXPRESSION; GRANULE CELL; HIPPOCAMPUS; HUMAN; KINDLING; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; REVIEW; SEIZURE; STRUCTURE ACTIVITY RELATION;

EID: 0036208979     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/107385840200800211     Document Type: Review

References (170)

1. Induction of brain-derived neurotrophic factor (BDNF) and the receptor trkB mRNA following middle cerebral artery occlusion in rat
2. Synaptic reorganization by mossy fibers in human epileptic fascia dentata
3. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain
4. Long-term potentiation and kindling: Similar biochemical mechanisms?
5. Transient increases in neuropeptide Y-like immunoreactivity in dentate hilar neurons following fimbria/fornix transection
6. Kainate, a double agent that generates seizures: Two decades of progress
7. Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures
8. Regulation of neurotrophin and trkB and trkC tyrosine kinase receptor messenger RNA expression in kindling
9. Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures
10. Altered distribution of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionate receptor subunit GluR2(4) and the N-methyl-D-aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal lobe epilepsy
11. Cellular pathology of hilar neurons in Ammon's horn sclerosis
12. Electrophysiological characteristics of reactive astrocytes in experimental cortical dysplasia
13. Neurodegenerative and morphogenic changes in a mouse model of temporal lobe epilepsy do not depend on the expression of the calcium binding proteins parvalbumin, calbindin, or calretinin
14. Unilateral LTP triggers bilateral increases in hippocampal neurotrophin and trk receptor mRNA expression in behaving rats: Evidence for interhemispheric communication
15. Kainic acid mediated increase of preprotachykinin A messenger RNA expression in the rat hippocampus and a region-selective attenuation by dexamethasone
16. Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy
17. Induction of calcitonin gene-related peptide-like immunoreactivity in hippocampal neurons following ischemia: A putative regional modulator of the CNS injury/immune response
18. Calcitonin gene-regulated peptide level in the rat dentate gyrus increases after damage
19. Regulation of brain-derived neurotrophic factor mRNA levels in hippocampus by neuronal activity
20. Mossy fiber synaptic reorganization induced by kindling: Time course of development, progression, and permanence
21. Changes in gene expression of AMPA-selective glutamate receptor subunits induced by status epilepticus in rat brain
22. Sensitivity of the rat hippocampal GABA(A) receptor alpha-4 subunit to electroshock seizures
23. Regulation of neuropeptides in adult rat forebrain by the neurotrophins BDNF and NGF
24. Impaired K+ homeostasis and altered electrophysiological properties of post-traumatic hippocampal glia
25. Electrolytic entorhinal lesions cause seizures
26. Sprouting of GABAergic and mossy fiber axons in dentate gyrus following intrahippocampal kainate in the rat
27. Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus
28. Kynurenine pathway enzymes in a rat model of chronic epilepsy: Immunohistochemical study of activated glial cells
29. Regionally-specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid
30. Differential regulation of catalytic and non-catalytic trkB messenger RNAs in the rat hippocampus following seizures induced by systemic administration of kainate
31. Dentate hilar mossy cells and somatostatin-containing neurons are immunoreactive for the α8 integrin subunit: Characterization in normal and kainic acid-treated rats
32. Delayed kindling development after rapidly recurring seizures: Relation to mossy fiber sprouting and neurotrophin, GAP-43 and dynorphin gene expression
33. Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis
34. A receptor gene expression in adult rat hippocampus: An in sutu hybridization study
35. Mossy cells of the rat dentate gyrus are immunoreactive for calcitonin-gene regulated peptide (CGRP)
36. GABAergic neurons and GABA(A) receptors in temporal lobe epilepsy
37. Seizure-induced changes in neurotrophin expression: Implications for epilepsy
38. Neuronal expression of AP-1 proteins in excitotoxic-neurodegenerative disorders and following nerve fiber lesions
39. BDNF, and full length and truncated TrkB expression in the hippocampus of the rat following kainic acid excitotoxic damage. Evidence of complex time-dependent and cell-specific responses
40. Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat
41. Kainic acid seizures cause enhanced expression of cholecystokinin-octapeptide in the cortex and hippocampus of the rat
42. Seizures induce simultaneous GABAergic and glutamatergic transmission in the dentate gyrus-CA3 system
43. Neuropeptide Y as a neuroproliferative factor
44. Opioid peptide expression in models of chronic temporal lobe epilepsy
45. Induction of somatostatin by kainic acid in pyramidal and granule cells of the rat hippocampus
46. Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances
47. Selective inhibition of axon outgrowth by antibodies to NGF in a model of temporal lobe epilepsy
48. Relationship between hippocampal opioid peptides and seizures
49. Repeated electroconvulsive shocks alter the biosynthesis of enkephalin and concentration of dynorphin in the rat brain
50. Granule cell dispersion in the dentate gyrus of humans with temporal lobe epilepsy
51. Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy
52. Activity and injury-dependent expression of inducible transcription factors, growth factors, and apoptosis-related genes within the central nervous system
53. Pentylenetetrazol seizures increase pro-nerve growth factor-like immunoreactivity in the reticular thalamic nucleus and nerve growth factor mRNA in the dentate gyrus
54. Correlated long-term increase of brain-derived neurotrophic factor and TrkB proteins in enlarged granule cells of mouse hippocampus after kainic acid injection
55. BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGF
56. Effects of pilocarpine- and kainate-induced seizures on thyrotropin-releasing hormone biosynthesis and receptors in the rat brain
57. Quantal components of unitary EPSCs at the mossy fiber synapse on CA3 pyramidal cells of rat hippocampus
58. A receptor subunit mRNAs in hippocampal pyramidal and granular neurons in the kindling model of epileptogenesis: An in situ hybridization study
59. Rat hippocampal kindling induces changes in the glutamate receptor mRNA expression patterns in dentate granule neurons
60. Dynorphin- and enkephalin-like immunoreactivity is altered in basal ganglia regions of rat brain after repeated electroconvulsive shock
61. Kainic acid alters the metabolism of met5-enkephalin and the level of dynorphin A in the rat hippocampus
62. A receptors
63. Attenuation of kindling-induced decreases in NT-3 mRNA by thyroid hormone depletion
64. Altered expression of NPY-Y1 receptors in kainic acid induced epilepsy in rats
65. A receptor subunit mRNA levels in dentate gyrus granule cells following recurrent kindling-induced seizures
66. Differential regulation of mRNAs for neuropeptide Y and its receptor subtypes in widespread areas of the rat limbic system during kindling epileptogenesis
67. Induction of brain derived neurotrophic factor mRNA by seizure neonatal and juvenile rat brain
68. Characterization of target cells for aberrant mossy fiber collaterals in the dentate gyrus of epileptic rat
69. Repeated electroconvulsive shocks cause transient changes in rat hippocampal somatostatin and neuropeptide Y immunoreactivity and mRNA in situ hybridization signals
70. Thyrotropin-releasing hormone gene expression and receptors are differentially modified in limbic foci by seizures
71. The role of mammalian ionotropic receptors in synaptic plasticity: LTP, LTD and epilepsy
72. Single and repeated electroconvulsive shock differentially affects the prodynorphin and proopiomelanocortin system in the rat
73. The prodynorphin system in the rat hippocampus is differentially influenced by kainic acid and pentetrazole
74. Effects of pentylenetetrazol kindling on glutamate receptor gene expression in the rat hippocampus
75. Seizure-related changes in the glutamate R2 and R5 receptor genes expression in the rat hippocampal formation
76. Patterns of status epilepticus-induced substance P expression during development
77. A receptor subtypes in human temporal lobe epilepsy
78. Prolonged increases in neurotrophic activity associated with kainate-induced hippocampal synaptic reorganization
79. Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy
80. Electroconvulsive stimuli enhance both neuropeptide Y receptor Y1 and Y2 messenger RNA expression and levels of binding in the rat hippocampus
81. Excitatory granule cells of the dentate gyrus exhibit a double inhibitory neurochemical content after intrahippocampal administration of kainate in adult mice
82. Adult generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles
83. Limbic seizures cause pronounced changes in the expression of neurokinin in the hippocampus of the rat
84. Neurotrophins and activity-dependent plasticity of cortical interneurons
85. Longitudinal variation in cell density and mossy fiber reorganization in the dentate gyrus from temporal lobe epileptic patients
86. Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy
87. Hippocampal N-methyl-D-aspartate receptor subunit mRNA levels in temporal lobe epilepsy patients
88. Hippocampal AMPA and NMDA mRNA levels correlate with aberrant fascia dentata mossy fiber sprouting in the pilocarpine model of spontaneous limbic epilepsy
89. Increased hippocampal AMPA and NMDA receptor subunit immunoreactivity in temporal lobe epilepsy
90. Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus
91. Biosynthesis and metabolism of native and oxidized neuropeptide Y in the hippocampal mossy fiber system
92. Dynorphin is contained within hippocampal mossy fibers: Immunochemical alterations after kainic acid administration and colchicine-induced neuotoxicity
93. Amygdaloid kindling increases enkephalin-like immunoreactivity but decreases dynorphin-A-like immunoreactivity in rat hippocampus
94. Excitatory amino acid receptors and epilepsy
95. Induction of F1/GAP-43 gene expression in hippocampal granule cells after seizures
96. Acute intrahippocampal infusion of brain-derived neurotrophic factor induces lasting potentiation of synaptic transmission in the rat dentate gyrus
97. Electroconvulsive shocks increase the expression of neuropeptide Y (NPY) mRNA in the piriform cortex and the dentate gyrus
98. Mapping patterns of c-fos expression in the central nervous system after seizure
99. Time-dependent changes in neurotrophic factor mRNA expression after kindling and long-term potentiation in rats
100. Alterations of perisomatic GABA synapses on hippocampal CA1 inhibitory interneurons and pyramidal cells in the kainate model of epilepsy
101. From mirror focus to secondary epileptogenesis in man: A historical review
102. Chronic delta FosB expression and increased AP-1 transcription factor binding are associated with the long term plasticity changes in epilepsy
103. Seizures increase trkC mRNA expression in the dentate gyrus of rat hippocampus. Role of glutamate receptor activation
104. Change in neurotrophins and their receptor mRNAs in the rat forebrain after status epilepticus induced by pilocarpine
105. Alternative splicing of the NMDAR1 glutamate receptor subunit in human temporal lobe epilepsy
106. Repeated ECS induces GluR1 mRNA but not NMDAR1A-G mRNA in the rat hippocampus
107. Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: Visualization after retrograde transport of biocytin
108. Recurrent mossy fiber pathway in rat dentate gyrus: Synaptic currents evoked in presence and absence of seizure-induced growth
109. Repeated electroconvulsive shock increase glial fibrillary acidic protein, ornithine decarboxylase, somatostatin, and cholecystokinin immunoreactivities in the hippocampal formation of the rat
110. Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat
111. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
112. Effect of electroconvulsive shock treatment on the opioid mediated inhibition of serotonin release in rat hippocampal slices
113. Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors
114. Axonal sprouting of CA1 pyramidal cells in hyperexcitable hippocampal slices of kainate-treated rats
115. Morphometry of a peptidergic transmitter system: Dynorphin B-like immunoreactivity in the rat hippocampal mossy fiber pathway before and after seizures
116. Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrozol-kindled rats
117. Status of somatostatin receptor messenger RNAs and binding sites in rat brain during kindling epileptogenesis
118. Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia
119. Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry
120. Long-lasting reduction of inhibitory function and gamma-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy
121. Autoradiographic analysis of neuropeptide Y receptor binding sites in the rat hippocampus after kainic acid induced limbic seizures
122. Alterations in mRNA of enkephalin, dynorphin and thyrotropin releasing hormone during amygdala kindling: An in situ hybridization study
123. Differential regional and time course increases in thyrotropin-releasing hormone, neuropeptide Y, and enkephalin mRNAs following an amygdala kindled seizure
124. Endogenous BDNF protein is increased in adult rat hippocampus after a kainic acid induced excitotoxic insult but exogenous BDNF is not neuroprotective
125. Axonal sprouting in layer V pyramidal neurons of chronically injured cerebral cortex
126. Coexistence of GABA and glutamate in mossy fiber terminals of the primate hippocampus: An ultrastructural study
127. Regional increases in brain-derived neurotrophic factor and nerve growth factor mRNAs during amygdaloid kindling, but not in acidic and basic growth factor mRNAs
128. Differentiation of rat dentate neurons by morphology and electrophysiology in hippocampal slices: Granule cells, spiny hilar cells, and aspiny, "fast-spiking" cells
129. Hyperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor
130. The role of nonprincipal cells in dentate gyrus excitability and its relevance to animal models of epilepsy and temporal lobe epilepsy
131. Actions of BDNF in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus
132. Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: Functional implications of seizure-induced neurogenesis
133. Synaptic connections of dentate granule cells and hilar neurons established by simultaneous intracellular recording in rat hippocampal slices
134. Dentate hilar mossy cells after pilocarpine-induced status epilepticus, recurrent seizures and mossy fiber sprouting
135. Cellular hybridization for BDNF, trkB, and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus
136. Decrease of neurotrophin-3 mRNA in adult rat hippocampus after pilocarpine seizures
137. Hippocampal granule cells express glutamic acid decarboxylase-67 after limbic seizures in the rat
138. Kindling induced neurogenesis in the dentate gyrus of the rat
139. Neurogenesis in the dentate gyrus of the rat following electroconvulsive shock seizures
140. Basal dendrites of granule cells are normal features of the fetal and adult dentate gyrus of both monkey and human hippocampal formations
141. Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats
142. Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus
143. Short- and long-term changes in CA1 network excitability after kainate treatment in rats
144. Characteristics of dentate gyrus granule cells with basal dendrites after pilocarpine-induced status epilepticus and recurrent seizures
145. Expression of GABA(A) receptor subunits in the hippocampus of the rat after kainic acid-induced seizures
146. Dentate granule cells form novel basal dendrites in a rat model of temporal lobe epilepsy
147. Electroconvulsive stimuli and brain peptides: Effect of modification of seizure duration on neuropeptide Y, neurokinin A, substance P and neurotensin
148. Brain neuropeptides: Changes by treatment with the convulsants pentylenetetrazole and bicuculline
149. Is cell death necessary for hippocampal mossy fiber sprouting?
150. Secondary epileptogenesis, kindling, and intractable epilepsy: A reappraisal from the perspective of neural plasticity
151. Mossy fiber synaptic reorganization in the epileptic human temporal lobe
152. Coordinated expression of messenger RNAs for nerve growth factor, brain-derived neurotrophic factor and neurotropin-3 in the rat hippocampus following transient forebrain ischemia
153. Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats
154. Synaptic plasticity and secondary epileptogenesis
155. Expression of brain-derived neurotrophic factor, nerve growth factor, and heat shock protein HSP70 following fluid percussion brain injury in rats
156. GABA(A) receptor subunits in the rat hippocampus III: Altered messenger RNA expression in kainic acid-induced epilepsy
157. Intraventricular administration of antibodies to nerve growth factor retards kindling and blocks mossy fiber sprouting in adult rats
158. Interleukin-1β immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: Functional evidence for enhancement of electrographic seizures
159. Plastic changes in neuropeptide Y receptor subtypes in experimental models of limbic seizures
160. Neuropeptide Y: Emerging evidence for a functional role in seizure modulation
161. Monosynaptic GABAergic signaling from dentate to CA3 with a pharmacological and physiological profile typical of mossy fiber synapses
162. Increased somatostatin and enkephalin-like immunoreactivity in hippocampus following hippocampal kindling
163. Self-sustaining status epilepticus: A condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators
164. Differential effects of electroconvulsive shock on the glutamate receptor mRNAs for NR2A, NR2B, and mGluR5b
165. Kainic acid-induced mossy fiber sprouting and synapse formation in the dentate gyrus of rats
166. Differential regulation of neuropeptide and proto-oncogene mRNA content in the hippocampus following recurrent seizures
167. Neurodegeneration and chronic seizures after bilateral entorhinal cortex gamma-acetylenic GABA injections in rats
168. Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats
169. A glutamate antagonist blocks perforant path stimulation-induced reduction of dynorphin peptide and prodynorphin mRNA levels in rat hippocampus
170. Ultrastructural localization of dynorphin in the dentate gyrus in human temporal lobe epilepsy: A study of reorganized mossy fiber synapses