Electroconvulsive stimuli enhance both neuropeptide Y receptor Y1 and Y2 messenger RNA expression and levels of binding in the rat hippocampus

Neuroscience

Volumn 98, Issue 1, 2000, Pages 33-39

  Madsen, T M ^a,b   Greisen, M H ^a   Nielsen, S M ^b   Bolwig, T G ^a   Mikkelsen, J D ^b,c  

^a Rigshospitalet   (Denmark)

^b H LUNDBECK A S   (Denmark)

^c Display Systems Biotech A/S   (Denmark)

Author keywords

Depression; Down regulation; Epilepsy; mRNA expression; Rat; Seizures

Indexed keywords

IODINE 125; MESSENGER RNA; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y [13-36]; NEUROPEPTIDE Y [31 LEUCINE 34 PROLINE]; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; PEPTIDE YY; RECEPTOR SUBTYPE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING COMPETITION; BINDING SITE; BRAIN REGION; CONTROLLED STUDY; DENTATE GYRUS; ELECTROSTIMULATION; GENE EXPRESSION; GRANULAR CELL; HIPPOCAMPUS; HISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SEIZURE;

ANIMALS; ANTI-ANXIETY AGENTS; ARGININE; AUTORADIOGRAPHY; DOWN-REGULATION; ELECTRIC STIMULATION THERAPY; EPILEPSY; GENE EXPRESSION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; IODINE RADIOISOTOPES; MALE; NEUROPEPTIDE Y; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, NEUROPEPTIDE Y; RNA, MESSENGER; SEIZURES;

EID: 0034110587     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00078-6     Document Type: Article

References (64)

1. Baraban S.C., Hollopeter G., Erickson J.C., Schwartzkroin P.A., Palmiter R.D. Knock-out mice reveal a critical antiepileptic role for neuropeptide Y. J. Neurosci. 17:1997;8927-8936.
2. 2+ influx into cultured dorsal root ganglion neurones of the rat via a Y2 receptor. Br. J. Pharmac. 103:1991;1781-1789.
3. Blomqvist A.G., Herzog H. Y-receptor subtypes-how many more? Trends Neurosci. 20:1997;294-298.
4. Caberlotto L., Fuxe K., Overstreet D.H., Gerrard P., Hurd Y.L. Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment. Brain Res. Molec. Brain Res. 59:1998;58-65.
5. Caberlotto L., Hurd Y.L. Reduced neuropeptide Y mRNA expression in the prefrontal cortex of subjects with bipolar disorder. NeuroReport. 10:1999;1747-1750.
6. Caberlotto L., Jimenez P., Overstreet D.H., Hurd Y.L., Mathe A.A., Fuxe K. Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression. Neurosci. Lett. 265:1999;191-194.
7. Chen J., Kelz M.B., Hope B.T., Nakabeppu Y., Nestler E.J. Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments. J. Neurosci. 17:1997;4933-4941.
8. Colmers W.F., Bleakman D. Effects of neuropeptide Y on the electrical properties of neurons. Trends Neurosci. 17:1994;373-379.
9. Colmers W.F., Klapstein G.J., Fournier A., St-Pierre S., Treherne K.A. Presynaptic inhibition by neuropeptide Y in rat hippocampal slice in vitro is mediated by a Y2 receptor. Br. J. Pharmac. 102:1991;41-44.
10. Croll S.D., Wiegand S.J., Anderson K.D., Lindsay R.M., Nawa H. Regulation of neuropeptides in adult rat forebrain by the neurotrophins BDNF and NGF. Eur. J. Neurosci. 6:1994;1343-1353.
11. Dalby N.O., Tønder N., Wolby D.P., West M., Finsen B., Bolwig T.G. No loss of hippocampal hilar somatostatinergic neurons after repeated electroconvulsive shock: a combined stereological and in situ hybridization study. Biol. Psychiat. 40:1996;54-60.
12. Daval J.L., Nakajima T., Gleiter C.H., Post R.M., Marangos P.J. Mouse brain c-fos mRNA distribution following a single electroconvulsive shock. J. Neurochem. 52:1989;1954-1957.
13. Devanand D.P., Dwork A.J., Hutchinson E.R., Bolwig T.G., Sackeim H.A. Does ECT alter brain structure? Am. J. Psychiat. 151:1994;957-970.
14. Diez M., Koistinaho J., DeArmond S.J., Camerino A.P., Groth D., Caytano J.C., Prusiner S.B., Hökfelt T. Aberrant induction of neuropeptide Y mRNA in hippocampal CA3 pyramidal neurones in scrapie-infected mice. NeuroReport. 7:1996;1887-1892.
15. Diez M., Koistinaho J., Dearmond S.J., Groth D., Prusiner S.B., Hokfelt T. Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease. Proc. natn. Acad. Sci. U.S.A. 94:1997;13267-13272.
16. Dumont Y., Fournier A., Quirion R. Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain. J. Neurosci. 18:1998;5565-5574.
17. Dumont Y., Fournier A., St-Pierre S., Quirion R. Comparative characterization and autoradiographic distribution of neuropeptide Y receptor subtypes in the rat brain. J. Neurosci. 13:1993;73-86.
18. Dumont Y., Jacques D., Bouchard P., Quirion R. Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4, and Y5 receptors in rodents, guinea pig, and primates brains. J. comp. Neurol. 402:1998;372-384.
19. Erickson J.C., Clegg K.E., Palmiter R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 381:1996;415-421.
20. Gariboldi M., Conti M., Cavaleri D., Samanin R., Vezzani A. Anticonvulsant properties of BIBP3226, a non-peptide selective antagonist at neuropeptide Y Y1 receptors. Eur. J. Neurosci. 10:1998;757-759.
21. Gehlert D.R., Gackenheimer S.L. Differential distribution of neuropeptide Y Y1 and Y2 receptors in rat and guinea-pig brains. Neuroscience. 76:1997;215-224.
22. Gemignani A., Marchese S., Fontana G., Raiteri M. Neuropeptide Y release from cultured hippocampal neurons: stimulation by glutamate acting at N-methyl-D-aspartate and AMPA receptors. Neuroscience. 81:1997;23-31.
23. Gerald C., Walker M.W., Criscione L., Gustafson E.L., Batzl-Hartmann C., Smith K.E., Vaysse P., Durkin M.M., Laz T.M., Linemeyer D.L., Schaffhauser A.O., Whitebread S., Hofbauer K.G., Taber R.I., Branchek T.A., Weinshank R.L. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 382:1996;168-171.
24. Gobbi M., Gariboldi M., Piwko C., Hoyer D., Sperk G., Vezzani A. Distinct changes in peptide YY binding to, and mRNA levels of, Y1 and Y2 receptors in the rat hippocampus associated with kindling epileptogenesis. J. Neurochem. 70:1998;1615-1622.
25. Greisen M.H., Sheikh S.P., Bolwig T.G., Mikkelsen J.D. Reduction of neuropeptide Y binding sites in the rat hippocampus after electroconvulsive stimulations. Brain Res. 776:1997;105-110.
26. Grundemar L. (1997) Multiple receptors and multiple actions. In Neuropeptide Y and Drug Development (eds Grundemar L. and Bloom S. R.). Academic Press, New York, pp. 1-14.
27. Gustafson E.L., Smith K.E., Durkin M.M., Walker M.W., Gerald C., Weinshank R., Branchek T.A. Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system. Brain Res. Molec. Brain Res. 46:1997;223-235.
28. Herzog H., Hort Y.J., Ball H.J., Hayes G., Shine J., Selbie L.A. Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc. natn. Acad. Sci. U.S.A. 89:1992;5794-5798.
29. Hökfelt T., Broberger C., Zhang X., Diez M., Kopp J., Xu Z., Landry M., Bao L., Schalling M., Koistinaho J., DeArmond S.J., Prusiner S., Gong J., Walsh J.H. Neuropeptide Y: some viewpoints on a multifaceted peptide in the normal and diseased nervous system. Brain Res. Brain Res. Rev. 26:1998;154-166.
30. Husum, H., Mikkelsen, J. D., Hogg, S., Mathé, A. A. and Mørk, A. (2000) Involvement of hippocampal neuropeptide Y in mediating the chronic actions of lithium, electroconvulsive stimulation and citalopram. Neuropharmacology.
31. Husum H., Mikkelsen J.D., Mork A. Extracellular levels of neuropeptide Y are markedly increased in the dorsal hippocampus of freely moving rats during kainic acid-induced seizures. Brain Res. 781:1998;351-354.
32. Kalra S.P., Kalra P.S. Nutritional infertility: the role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network. Front Neuroendocrinol. 17:1996;371-401.
33. Kofler N., Kirchmair E., Schwarzer C., Sperk G. Altered expression of NPY-Y1 receptors in kainic acid induced epilepsy in rats. Neurosci. Lett. 230:1997;129-132.
34. Kubek M.J., Knoblach S.M., Sharif N.A., Burt D.R., Buterbaugh G.G., Fuson K.S. Thyrotropin-releasing hormone gene expression and receptors are differentially modified in limbic foci by seizures. Ann. Neurol. 33:1993;70-76.
35. Larsen P.J., Kristensen P. The neuropeptide Y (Y4) receptor is highly expressed in neurones of the rat dorsal vagal complex. Molec. Brain Res. 48:1997;1-6.
36. Larsen P.J., Sheikh S.P., Jakobsen C.R., Schwartz T.W., Mikkelsen J.D. Regional distribution of putative NPY Y1 receptors and neurons expressing Y1 mRNA in forebrain areas of the rat central nervous system. Eur. J. Neurosci. 5:1993;1622-1637.
37. Leranth C., Nitsch R., Deller T., Frotscher M. Synaptic connections of seizure-sensitive neurons in the dentate gyrus. Epilepsy Res. Suppl. 7:1992;49-64.
38. Löscher W., Ebert U. The role of the piriform cortex in kindling. Prog. Neurobiol. 50:1996;427-481.
39. Marksteiner J., Ortler M., Bellmann R., Sperk G. Neuropeptide Y biosynthesis is markedly induced in mossy fibers during temporal lobe epilepsy of the rat. Neurosci. Lett. 112:1990;143-148.
40. Marsh D.J., Baraban S.C., Hollopeter G., Palmiter R.D. Role of the Y5 neuropeptide Y receptor in limbic seizures. Proc. natn. Acad. Sci. U.S.A. 96:1999;13518-13523.
41. Marsh D.J., Hollopeter G., Kafer K.E., Palmiter R.D. Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat. Med. 4:1998;718-721.
42. McQuiston A.R., Petrozzino J.J., Connor J.A., Colmers W.F. Neuropeptide Y1 receptors inhibit N-type calcium currents and reduce transient calcium increases in rat dentate granule cells. J. Neurosci. 16:1996;1422-1429.
43. Medanic M., Gillette M.U. Suprachiasmatic circadian pacemaker of rat shows two windows of sensitivity to neuropeptide Y in vitro. Brain Res. 620:1993;281-286.
44. Mikkelsen J.D., Larsen P.J. A high concentration of NPY (Y1)-receptor mRNA-expressing cells in the rat arcuate nucleus. Neurosci. Lett. 148:1992;195-198.
45. Mikkelsen J.D., Woldbye D., Kragh J., Larsen P.J., Bolwig T.G. Electroconvulsive shocks increase the expression of neuropeptide Y (NPY) mRNA in the piriform cortex and the dentate gyrus. Molec. Brain Res. 23:1994;317-322.
46. Munglani R., Hudspith M.J., Hunt S.P. The therapeutic potential of neuropeptide Y. Analgesic, anxiolytic and antihypertensive. Drugs. 52:1996;371-389.
47. Pollard H., Charriaut-Marlangue C., Cantagrel S., Represa A., Robain O., Moreau J., Ben-Ari Y. Kainate-induced apoptotic cell death in hippocampal neurons. Neuroscience. 63:1994;7-18.
48. 2+ entry. J. Neurosci. 17:1997;8169-8177.
49. Röder C., Schwarzer C., Vezzani A., Gobbi M., Mennini T., Sperk G. Autoradiographic analysis of neuropeptide Y receptor binding sites in the rat hippocampus after kainic acid-induced limbic seizures. Neuroscience. 70:1996;47-55.
50. Rudolf K., Eberlein W., Engel W., Beck-Sickinger A. G., Wittneben H., Wieland H. A. and Dodds H. (1997) BIBP 3226, a potent and selective neuropeptide Y Y1 receptor antagonist. Structure-activity studies and localisation of the human Y1 binding site. In Neuropeptide Y and Drug Development (eds Grundemar L. and Bloom S. R.). Academic Press, New York, pp. 175-190.
51. Sackeim H.A., Decina P., Kanzler M., Kerr B., Malitz S. Effects of electrode placement on the efficacy of titrated, low-dose ECT. Am. J. Psychiat. 144:1987;1449-1455.
52. Schwarzer C., Kofler N., Sperk G. Up-regulation of neuropeptide Y-Y2 receptors in an animal model of temporal lobe epilepsy. Molec. Pharmac. 53:1998;6-13.
53. Schwarzer C., Sperk G., Samanin R., Rizzi M., Gariboldi M., Vezzani A. Neuropeptides-immunoreactivity and their mRNA expression in kindling: functional implications for limbic epileptogenesis. Brain Res. Rev. 22:1996;27-50.
54. Stanley B.G., Kyrkouli S.E., Lampert S., Leibowitz S.F. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides. 7:1986;1189-1192.
55. Stenfors C., Theodorsson E., Mathe A.A. Effect of repeated electroconvulsive treatment on regional concentrations of tachykinins, neurotensin, vasoactive intestinal polypeptide, neuropeptide Y, and galanin in rat brain. J. Neurosci. Res. 24:1989;445-450.
56. Thiele T.E., Marsh D.J., Ste.Marie L., Bernstein I.L., Palmiter R.D. Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature. 396:1998;366-369.
57. Vezzani A., Sperk G., Colmers W.F. Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci. 22:1999;25-30.
58. Wahlestedt C., Blendy J.A., Kellar K.J., Heilig M., Widerlov E., Ekman R. Electroconvulsive shocks increase the concentration of neocortical and hippocampal neuropeptide Y (NPY)-like immunoreactivity in the rat. Brain Res. 507:1990;65-68.
59. Wahlestedt C. and Heilig M. (1995) Neuropeptide Y and related peptides. In Psychopharmacology. The Fourth Generation of Progress! (eds Bloom F. E. and Kupfer D. J.), Raven Press, New York, pp. 543-551.
60. Woldbye D.P., Greisen M.H., Bolwig T.G., Larsen P.J., Mikkelsen J.D. Prolonged induction of c-fos in neuropeptide Y- and somatostatin- immunoreactive neurons of the rat dentate gyrus after electroconvulsive stimulation. Brain Res. 720:1996;111-119.
61. Woldbye D.P., Larsen P.J., Mikkelsen J.D., Klemp K., Madsen T.M., Bolwig T.G. Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Nat. Med. 3:1997;761-764.
62. Xie C.W., Lee P.H., Takeuchi K., Owyang V., Li S.J., Douglass J., Hong J.S. Single or repeated electroconvulsive shocks alter the levels of prodynorphin and proenkephalin mRNAs in rat brain. Molec. Brain Res. 6:1989;11-19.
63. Zachrisson O., Mathe A.A., Stenfors C., Lindefors N. Limbic effects of repeated electroconvulsive stimulation on neuropeptide Y and somatostatin mRNA expression in the rat brain. Brain Res. Molec. Brain Res. 31:1995;71-85.
64. Zimanyi I.A., Fathi Z., Poindexter G.S. Central control of feeding behavior by neuropeptide Y. Curr. Pharm. Des. 4:1998;349-366.