Hippocampal N-methyl-D-aspartate receptor subunit mRNA levels in temporal lobe epilepsy patients

Annals of Neurology

Volumn 46, Issue 3, 1999, Pages 343-358

  Mathern, Gary W ^a,f   Pretorius, James K ^a   Mendoza, Delia ^a   Leite, Joao P ^c   Chimelli, Leila ^c   Born, Donald E ^d   Fried, Itzhak ^a   Assirati, Joao A ^c   Ojemann, George A ^d   Adelson, P David ^e   Cahan, Leslie D ^b   Kornblum, Harley I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Neurosurgery   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ARTICLE; AUTOPSY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR DENSITY; RNA ANALYSIS; TEMPORAL LOBE EPILEPSY; TISSUE DISTRIBUTION;

ADOLESCENT; ADULT; AGED; AUTORADIOGRAPHY; CHILD; CHILD, PRESCHOOL; EPILEPSY, TEMPORAL LOBE; FEMALE; HIPPOCAMPUS; HUMANS; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER;

EID: 0032833076     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(199909)46:3<343::AID-ANA10>3.0.CO;2-S     Document Type: Article

References (77)

1. Hollmann M, Heinemann S. Cloned glutamate receptors. Annu Rev Neurosci 1994;17:31-108
2. Collingridge GL, Lester RAJ. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol Rev 1989; 40:145-195
3. Collingridge GL, Singer W. Excitatory amnio acid receptors and synaptic plasticity. Trends Pharmacol Sci 1990;11:290-296
4. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988;1:623-634
5. Dingledine R, McBain CJ, McNamara JO. Excitatory amino acid receptors in epilepsy. Trends Pharmacol Sci 1990;11:334-338
6. Moriyoshi K, Masu M, Ishii T, et al. Molecular cloning and characterization of the rat NMDA receptor. Nature 1991;354: 31-37
7. Sommer B, Seeburg PH. Glutamate receptor channels: novel properties and new clones. Trends Pharmacol Sci 1992;13:291-296
8. Meguro H, Mori H, Araki K, et al. Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature 1992;357:70-74
9. Monyer H, Sprengel R, Schoepfer R, et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 1992;256:1217-1221
10. Isokawa M, Lévesque MF. Increased NMDA responses and dendritic degeneration in human epileptic hippocampal neurons in slices. Neurosci Lett 1991;132:212-216
11. Masukawa LM, Uruno K, Sperling M, et al. The functional relationship between antidromically evoked field responses of the dentate gyrus and mossy fiber reorganization in temporal lobe epileptic patients. Brain Res 1992;579:119-127
12. Franck JE, Pokorny J, Kunkel DD, Schwartikroin PA. Physiologic and morphologic characteristics of granule cell circuitry in human epileptic hippocampus. Epilepsia 1995;36:543-558
13. Mathern GW, Leite JP, Babb TL, et al. Aberrant hippocampal mossy fiber sprouting correlates with greater NMDAR2 receptor staining. Neuroreport 1996;7:1029-1035
14. Mathern GW, Pretorius JK, Kornblum HI, et al. Human hippocampal AMPA and NMDA mRNA levels in temporal lobe epilepsy patients. Brain 1997;120:1937-1959
15. Williamson A, Spencer DD. Electrophysiological characterization of CA2 pyramidal cells from epileptic humans. Hippocampus 1994;4:226-237
16. Geddes JW, Cahan LD, Cooper SM, et al. Altered distribution of excitatory amino acid receptors in temporal lobe epilepsy. Exp Neurol 1990;108:214-220
17. Hosford DA, Crain BJ, Cao Z, et al. Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus. J Neurosci 1991;11: 428-434
18. McDonald JW, Garofalo EA, Hood T, et al. Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy. Ann Neurol 1991;29: 529-541
19. Bayer TA, Wietsler OD, Wolf HK. Hippocampal loss of N-methyl-D-aspartate receptor subunit 1 mRNA in chronic temporal lobe epilepsy. Acta Neuropathol 1995;89:446-450
20. Blümcke I, Beck H, Scheffler B, et al. Altered distribution of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4) and the N-methyl-D-aspartate receptor subunit NMDSR1 in the hippocampus of patients with temporal lobe epilepsy. Acta Neuropathol 1996;92:576-587
21. Engel J Jr. Surgical treatment of the epilepsies, 2nd ed. New York: Raven Press, 1993
22. Engel J Jr, Lévesque MF, Crandall PH, et al. The epilepsies. In: Grossman RG, ed. Principles of neurosurgery. New York: Raven Press, 1991:319-358
23. Mathern GW, Babb TL, Armstrong DL. Hippocampal sclerosis. In: Engel J Jr, Pedley TA, eds. Epilepsy: a comprehensive textbook. New York: Raven Press, 1997:133-155
24. Wieser HG, Engel J Jr, Williamson PD, et al. Surgically remediable temporal lobe syndromes. In: Engel J Jr, ed. Surgical treatment of the epilepsies, 2nd ed. New York: Raven Press, 1993:49-63
25. Babb TL, Brown WJ. Pathological findings in epilepsy. In: Engel J Jr, ed. Surgical treatment of the epilepsies. New York: Raven Press, 1987:511-540
26. Mathern GW, Babb TL, Vickrey BG, et al. The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy. Brain 1995;118:105-113
27. Mathern GW, Babb TL, Pretorius JK, et al. The pathophysiologic relationships between lesion pathology, intracranial ictal EEG onsets, and hippocampal neuron losses in temporal lobe epilepsy. Epilepsy Res 1995;21:133-147
28. Crandall PH, Mathern GW. Surgery for lesional temporal lobe epilepsy. In: Lüders HO, Comair Y, eds. Epilepsy surgery, 2nd ed. New York: Lippincott-Raven, 1999 (In press)
29. Babb TL, Brown WJ, Pretorius J, et al. Temporal lobe volumetric cell densities in temporal lobe epilepsy. Epilepsia 1984; 25:729-740
30. Babb TL, Lieb JP, Brown WJ, et al. Distribution of pyramidal cell density and hyperexcitability in the epileptic human hippocampus. Epilepsia 1984;25:721-728
31. Mathern GW, Kuhlman PA, Mendoza D, Pretorius JK. Human fascia dentata stratum granulosum and hilar areas, and hippocampal neuron counts differ depending on the epileptic syndrome and age at first seizures. J Neuropathol Exp Neurol 1997;56:199-212
32. Abercrombie M. Estimation of nuclear population from microtome sections. Anat Rec 1946;94:239-247
33. Lorente de N6 R. Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system. J Psychol Neurol 1934;45:113-177
34. Amaral DG, Campbell MJ. Transmitter systems in the primate dentate gyrus. Human Neurobiol 1986;5:169-180
35. Cruz-Orive LM, Weibel ER. Recent stereological methods for cell biology: a brief survey. Am J Physiol 1990;258:L148-L156
36. Mayhew TM. A review of recent advances in stereology for quantifying neural structure. J Neurocytol 1992;21:313-328
37. West MJ. Stereological studies of the hippocampus: a comparison of the hippocampal subdivisions of diverse species including hedgehogs, laboratory rodents, wild mice and men. Prog Brain Res 1990;83:13-36
38. Coggeshall RE, Lekan HA. Methods for determining numbers of cells and synapses: a case for more uniform standards of review. J Comp Neurol 1996;364:6-15
39. Mouritzen-Dam A. Epilepsy and neuron loss in the hippocampus. Epilepsia 1980;21:617-619
40. Mathern GW, Babb TL, Mischel PS, et al. Childhood generalized and mesial temporal epilepsies demonstrate different amounts and patterns of hippocampal neuron loss and mossy fiber synaptic reorganization. Brain 1996;119:965-987
41. Cox K, De Leon DV, Angerer LM, Angerer RC. Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes. Dev Biol 1984;101:485-502
42. Gall C, Isackson PJ. Limbic seizures increase neuronal production of messenger RNA for nerve-growth factor. Science 1989; 245:758-761
43. Kornblum HI, Chugani HT, Tatsukawa K, Gall CM. Cerebral hemidecortication alters expression of transforming growth factor alpha mRNA in the neostriatum of developing rats. Mol Brain Res 1994;21:107-114
44. Mathern GW, Pretorius JK, Kornblum HI, et al. Altered hippocampal kainate-receptor mRNA levels in temporal lobe epilepsy patients. Neurobiol Dis 1998;5:151-176
45. Gold SJ, Hennegriff M, Lynch G, Gall CM. Relative concentrations and seizure-induced changes in mRNAs encoding three AMPA receptor subunits in hippocampus and cortex. J Comp Neurol 1996;365:541-555
46. Johnson M, Perry RH, Piggott MA, et al. Glutamate receptor binding in the human hippocampus and adjacent cortex during development and aging. Neurobiol Aging 1996;17:639-651
47. Scherzer CR, Landwehrmeyer GB, Kerner JA, et al. Expression of N-methyl-D-aspartate receptor subunit mRNA in the human brain: hippocampus and cortex. J Comp Neurol 1998;390: 75-90
48. Weiss SW, Albers DS, Iadarola MJ, et al. NMDAR1 glutamate receptor subunit isoforms in neostriatal, neocortical, and hippocampal nitric oxide synthase neurons. J Neurosci 1998;18: 1725-1734
49. Lambolez B, Audinat E, Bochet P, et al. AMPA receptor subunits expressed by single Purkinje cells. Neuron 1992;9:247-258
50. Bochet P, Audinat E, Lambolez B, et al. Subunit composition at the single-cell level explains functional properties of a glutamate-gated channel. Neuron 1994;12:383-388
51. 2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron 1995;15:193-204
52. Mathern GW, Pretorius JK, Mendoza D, et al. Increased hippocampal AMPA and NMDA receptor subunit immunoreactivity in temporal lobe epilepsy patients. J Neuropathol Exp Neurol 1998;57:615-634
53. Mathern GW, Price G, Rosales C, et al. Anoxia during kainate status epilepticus shortens behavioral convulsions but generates hippocampal neuron loss and supragranular mossy fiber sprouting. Epilepsy Res 1998;30:133-151
54. Urban L, Aitken PG, Friedman A, Somjen GG. An NMDA-mediated component of excitatory synaptic input to dentate granule cells in "epileptic" hippocampus studied in vitro. Brain Res 1990;515:319-322
55. Masukawa LM, Higashima M, Hart GJ, et al. NMDA receptor activation during epileptiform responses in the dentate gyrus of epileptic patients. Brain Res 1991;562:176-180
56. Williamson A, Spencer DD, Shepherd GM. Comparison between the membrane and synaptic properties of human and rodent dentate granule cells. Brain Res 1993;622:194-202
57. Isokawa M, Lévesque M, Fried I, Engel J Jr. Glutamate currents in morphologically identified human dentate granule cells in temporal lobe epilepsy. J Neurophysiol 1997;77:3355-3369
58. Williamson A, McCormick DA, Shepherd CM, Spencer DD. Intracellular recordings from epileptic human dentate granule cells show evidence of hyperexcitability. Epilepsia 1990;31:625 (Abstract)
59. Mody I, Heinemann U. NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling. Nature 1987;326:701-704
60. Isokawa M, Mello LEAM. NMDA receptor-mediated excitability in dendritically deformed dentate granule cells in pilocarpine-treated rats. Neurosci Lett 1991;129:69-73
61. Pratt GD, Kokaia M, Bengzon J, et al. Differential regulation of N-methyl-D-aspartate receptor subunit messenger RNAs in kindling-induced epileptogenesis. Neuroscience 1993;57:307-318
62. Köhr G, Mody I. Kindling increases N-methyl-D-aspartate potency at single N-methyl-D-aspartate channels in dentate gyrus granule cells. Neuroscience 1994;62:75-81
63. Williamson A, Spencer DD. Zinc reduces dentate granule cell hyperexcitability in epileptic humans. NeuroReport 1995;6: 1562-1564
64. Sakimura K, Kutsuwada T, Ito I, et al. Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor el subunit. Nature 1995;373:151-155
65. Sprengel R, Suchanek B, Amico C, et al. Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell 1998;92:279-289
66. Michaelis EK. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog Neurobiol 1998;54:369-415
67. Ikeda K, Nagasawa M, Mori H, et al. Cloning and expression of the epsilon-4 subunit of the NMDA receptor channel. FEBS Lett 1992;313:34-38
68. Kutsuwada T, Kashiwabuchi N, Mori H, et al. Molecular diversity of the NMDA receptor channel. Nature 1992;358: 36-41
69. Buller AL, Larson H, Schneider HC, et al. The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition. J Neurosci 1994;14:5471-5484
70. Köhr G, Eckardt S, Luddens H, et al. NMDA receptor channels: subunit-specific potentiation by reducing agents. Neuron 1994;12:1031-1040
71. Molinoff PB, Williams K, Pritchett K, Zhong J. Molecular pharmacology of NMDA receptors: modulatory role of NR2 subunits. In: Bloom F, ed. Progress in brain research, vol 100. Amsterdam: Elsevier, 1994:39-45
72. Monyer H, Burnashev N, Laurie DJ, et al. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 1994;12:529-540
73. Köhr G, Seeburg PH. Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family. J Physiol (Lond) 1996;492:445-452
74. Krupp JJ, Vissel B, Heinemann SF, Westbrook GL. Calcium-dependent inactivation of recombinant N-methyl-n-aspartate receptors in NR2 subunit specific. Mol Pharmacol 1996;50: 1680-1688
75. Williams K. Separating dual effects of zinc at recombinant N-methyl-D-aspartate receptors. Neurosci Lett 1996;215:9-12
76. Paoletti P, Ascher P, Neyton J, High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J Neurosci 1997;17:5711-5725
77. Chen N, Moshaver A, Raymond LA. Differential sensitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition. Mol Pharmacol 1997;51:1015-1023