Gap junctions and tumour progression

Canadian Journal of Physiology and Pharmacology

Volumn 80, Issue 2, 2002, Pages 136-141

  Naus, Christian C G ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Cancer; Connexin; Gap junctions

Indexed keywords

CONNEXIN 43; CYSTEINE RICH PROTEIN 61; GAP JUNCTION PROTEIN; MESSENGER RNA; NERVE GROWTH FACTOR; PROTEIN; PROTEIN L19; RIBOSOME PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL PROLIFERATION; GAP JUNCTION; GENE EXPRESSION REGULATION; GROWTH REGULATION; HOMEOSTASIS; ION EXCHANGE; MOLECULE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECOND MESSENGER; TUMOR GROWTH;

CELL COMMUNICATION; CELL DIFFERENTIATION; CONNEXINS; DISEASE PROGRESSION; GAP JUNCTIONS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; NEOPLASMS;

EID: 0036203586     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y02-009     Document Type: Article

References (73)

1. Expression of gap junctions in cultured rat L6 cells during myogenesis
2. Reduction of connexin43 expression and dye-coupling during neuronal differentiation of human NTera2/Clone D1 cells
3. Gap junction blockage interferes with neuronal and astroglial differentiation of mouse P19 embryonal carcinoma cells
4. The effects of gap junction blockage on neuronal differentiation of human NTera2/clone D1 cells
5. Analysis of connexin43 expression under the control of a metallothionein promoter
6. Connexin expression in neurons and astrocytes derived from P19 embryonal carcinoma cells
7. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy
8. Transfection of C6 glioma cells with connexin32: The effects of expression of a nonendogenous gap junction protein
9. The modular architecture of a new family of growth regulators related to connective tissue growth factor
10. Switch in gap junction protein expression is associated with selective changes in junctional permeability during keratinocyte differentiation
11. Identification of a gene family regulated by transforming growth factor-β
12. Intercellular signaling in glial cells: Calcium waves and oscillations in response to mechanical stimulation and glutamate
13. Intercellular calcium signaling via gap junctions in glioma cells
14. Expression of immediate early gene cyr61 during the differentiation of immortalized embryonic hippocampal neuronal cells
15. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
16. Localization and function of the connexin 43 gap-junction protein in normal and various oncogene-expressing rat liver epithelial cells
17. Gap junctions promote the bystander effect of Herpes Simplex thymidine kinase in vivo
18. Expression of gap junction channels in communication-incompetent cells after stable transfection with cDNA encoding connexin32
19. Cytoplasmic dye transfer between metastatic tumor cells and vascular endothelium
20. Adhesion-mediated gap junctional communication between lung- metastatic cancer cells and endothelium
21. Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase ganciclovir system in vitro
22. Heart and neural tube defects in trans-genic mice overexpressing the Cx43 gap junction gene
23. The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro
24. Molecular characterization and functional expression of the human cardiac gap junction channel
25. The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein
26. Direct isolation and analysis of endogenous transjunctional ADP from Cx43 transfected C6 glioma cells
27. Selective transfer of endogenous metabolites through gap junctions composed of different connexins
28. Connexin43 suppresses MFG-E8 while inducing contact growth inhibition of glioma cells
29. Inhibition of glioma cell growth and tumorigenic potential by CCN3(NOV)
30. Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells
31. High-level expression of the ribosomal proteinb L19 in human breast tumors that overexpress erbB-2
32. Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential
33. Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43)
34. Identification of connexin-interacting proteins: Application of the yeast two-hybrid screen
35. Restoration of gap-junctional intercellular communication in a communication-deficient rat liver cell mutant by transfection with connexin 43 cDNA
36. Gap junctional communication and compaction during preimplantation stages of mouse development
37. Positive selection of candidate tumor-suppressor genes by subtractive hybridization
38. Differential expression of novH and CTGF in human glioma cell lines
39. Junctional intercellular communication and the control of growth
40. The cell-to-cell channel of gap junctions
41. In vivo association of pp60v-src and the gap-junction protein connexin 43 in v-src-transformed fibroblasts
42. Experimental therapy of human glioma by means of genetically engineered virus mutant
43. Immortalized connexin43 knockout cell lines display a subset of biological properties associated with the transformed phenotype
44. Determination of a potential role for Cyr61 and Nov in connexin43 transfected C6 glioma cells
45. Growth inhibition of transformed cells correlates with their junctional communication with normal cells
46. Bystander killing of cancer cells by HSV-TK gene is mediated by connexins
47. Gap junctional communication in the developing central nervous system
48. In vivo growth of C6 glioma cells transfected with connexin43 cDNA
49. Identification of genes differentially expressed in C6 glioma cells transfected with connexin43
50. Expression of the growth factor-inducible immediate early gene cyr61 correlates with chondrogenesis during mouse embryonic development
51. Mutated connexin43 proteins inhibit rat glioma cell growth suppression mediated by wild-type connexin43 in a dominant-negative manner
52. Expression of a dominant negative inhibitor of intercellular communication in the early Xenopus embryo causes delamination and extrusion of cells
53. NOV (nephroblastoma overexpressed) and the CCN family of genes: Structural and functional issues
54. Blocking gap junctional intercellular communication in myoblasts inhibits myogenin and MRF4 expression
55. Transfection of rhabdomyosarcoma cells with connexin43 induces myogenic differentiation
56. Cardiac malformation in neonatal mice lacking connexin43
57. Gap junctions in the nervous system
58. Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions
59. Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses
60. Connexin 43 and the glucose transporter, glut1, in the ciliary body of the rat
61. Protein and messenger RNA expression of connexin43 in astrocytomas: Implications in brain tumor gene therapy
62. Diverse functions of vertebrate gap junctions
63. v-src-induced inhibition of communication
64. Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion
65. High incidence of spontaneous and chemically induced liver tumors in mice deficeint for connexin32
66. Specificity of gap junction communication among human mammary cells and connexin transfectants in culture
67. Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors
68. Gap junctions in development - A perspective
69. Role of connexin genes in growth control
70. Cyr61, product of a growth factor-inducible immediate early gene, is associated with the extracellular matrix and the cell surface
71. Transfection of C6 glioma cells with connexin 43 cDNA: Analysis of expression, intercellular coupling, and cell proliferation
72. Growth retardation in glioma cells cocultured with cells overexpressing a gap junction protein
73. Growth retardation in glioma cells cocultured with cells over-expressing a gap junction protein