Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV)

Journal of Clinical Pathology - Molecular Pathology

Volumn 54, Issue 5, 2001, Pages 293-299

  Gupta, N ^a   Wang, H ^a   McLeod, T L ^b   Naus, C C G ^b   Kyurkchiev, S ^c   Advani, S ^a   Yu, J ^a   Perbal, B ^c   Weichselbaum, R R ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c Faculty of Medicine   (France)

Author keywords

CCN3; Connexin 43; CTGF; CYR61; Extracellular matrix; Gap junctional intercellular communication; Human glioma; NOVH

Indexed keywords

CCN3 PROTEIN; CELL PROTEIN; CONNEXIN 43; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CELL COMMUNICATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; GENE; GLIOMA CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ANIMALS; CELL COMMUNICATION; CELL DIVISION; CONNEXIN 43; FEMALE; GENE EXPRESSION; GLIOMA; HUMANS; MICE; MICE, NUDE; MODELS, ANIMAL; RATS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0034808528     PISSN: 13668714     EISSN: None     Source Type: Journal    
DOI: 10.1136/mp.54.5.293     Document Type: Article

References (31)

1. Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas
2. Contribution of MAV-1-induced nephroblastoma to the study of genes involved in human Wilms' tumor development
3. The modular architecture of a new family of growth regulators related to connective tissue growth factor
4. The CCN family of angiogenic regulators: The connection
5. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family
6. Nov (nephroblastoma overexpressed) and the CCN family of genes: Structural and functional issues
7. The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p
8. Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10
9. Physical mapping of human loci homologous to the chicken nov protooncogene
10. WISP genes are members of the connective tissue growth factor family that are up-regulated in Wnt-1-transformed cells and aberrantly expressed in human colon tumors
11. Report on the first international workshop on the CCN family of genes
12. Expression of the human nov gene in first trimester fetal tissues
13. Caractérisation et expression du proto-oncogéne nov humain dans les tumeurs de Wilms
14. The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: A clue for a role of NOVH in cell-adhesion signaling
15. Transcriptional down regulation of the nov proto-oncogene in fibroblasts transformed by p60v-src
16. Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation
17. A developmental study of novH gene expression in human central nervous system
18. NovH: Differential expression in developing kidney and Wilms' tumors
19. Differential expression of novH and CTGF in human glioma cell lines
20. The Nov gene encodes an adhesion factor for vascular smooth muscle cells and is dynamically regulated in response to injury
21. Transfection of C6 glioma cells with connexin 43 cDNA: Analysis of expression, intercellular coupling, and cell proliferation
22. Expression of gap junction genes in astrocytes and C6 glioma cells
23. Role of connexin genes in growth control
24. Identification of genes differentially expressed in C6 glioma cells transfected with connexin 43
25. CYR61 stimulates human skin fibroblast migration through integrin αv β5 beta5 and enhances mitogenesis through integrin αv β3, independent of its carboxyl-terminal domain
26. Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha6 beta1 and cell surface heparan sulfate proteoglycans
27. The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts
28. CYR61, a product of a growth factor inducible immediate early gene, promotes angiogenesis and tumor growth
29. Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin αv β3, promotes endothelial cell survival, and induces angiogenesis in vivo
30. Specific genomic alterations associated with poor prognosis in high grade renal cell carcinomas