Liver regeneration: The emergence of new pathways

Medical Science Monitor

Volumn 8, Issue 3, 2002, Pages

  Zimmermann, Arthur ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Bile duct regeneration; Hepatocyte growth; Liver regeneration

Indexed keywords

BILE DUCT; CELL CYCLE G0 PHASE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL STIMULATION; HUMAN; LIVER CELL; LIVER CIRCULATION; LIVER REGENERATION; REVIEW; STELLATE CELL; STEM CELL;

ANIMALS; CELL DIVISION; DISEASE MODELS, ANIMAL; G0 PHASE; HEPATOCYTES; HUMANS; LIVER; LIVER DISEASES; REGENERATION;

EID: 0036201055     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (106)

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3. Proliferation of mononuclear phagocytes (Kupffer cells) and endothelial cells in regenerating rat liver
4. Heterogeneity and plasticity of hepatocyte lineage cells
5. Lessons from genetically engineered animal models V. Knocking out genes to study liver regeneration: Present and future
6. Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene
7. Replacement of diseased mouse liver by hepatic cell transplantation
8. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes
9. Hepatocytes break the rules of senescence in serial transplantation studies. Is there a limit to their replicative capacity?
10. DNA polymerases and Ki-67 nuclear antigen are induced in correlation with the resected mass of rat liver up to 90%
11. Cell cycle control during liver development in the rat: Evidence indicating a role for cyclin D1 posttranscriptional regulation
12. The compensatory hyperplasia (liver regeneration) following ligation of a portal branch is initiated before the atrophy of the deprived lobes
13. The extent of synchronous initiation and termination of DNA synthesis in regenerating mouse liver is dependent on connexin32 expressing gap junctions
14. Increased secretion of tumor necrosis factor and interleukin 6 from isolated, perfused liver of rats after partial hepatectomy
15. Effect of TNF gene depletion on liver regeneration after partial hepatectomy in mice
16. Cytokine regulation of liver injury and repair
17. Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor κB activation
18. Tumor necrosis factor primes hepatocytes for DNA replication in the rat
19. Interleukin 6 and liver regeneration. Review
20. Hepatocellular hyperplasia, plasmocytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice
21. Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury
22. Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration
23. Levels of interleukin (IL)-6, IL-8, and IL-1 receptor antagonist in the hepatic vein following liver surgery
24. Concanavalin A simultaneously primes liver hematopoietic and epithelial progenitor cells parallel expansion during liver regeneration after partial hepatectomy in mice
25. Normal pharmacologically-induced, but decreased regenerative liver growth in interleukin-6-deficient (IL-6 (-/-)) mice
26. IL-6 protects against Fasmediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl2 and Bcl-xL
27. Expression of bcl-2 family reduces apoptotic hepatocytes after excessive hepatectomy
28. Hyperstimulation with interleukin 6 inhibits cell cycle progression after hepatectomy in mice
29. The mitogenic activity of hepatocyte growth factor is dependent upon endogenous transforming growth factor-alpha
30. Hepatocyte growth factor induces MAT2A expression and histone acetylation in rat heptocytes: Role in liver regeneration
31. TNF-alpha regulates transforming growth factor-alpha expression in regenerating murine liver and isolated hepatocytes
32. Epidermal growth factor is decreased in liver of rats with biliary cirrhosis but does not act as paracrine growth factor immediately after hepatectomy
33. The IGF axis and hepato-carcino-genesis
34. Increased insulin-like growth factor binding protein-4 expression after partial hepatectomy in the rat
35. Transforming growth factor-beta 1 recruits histone deacetylase 1 to p130 repressor complex in transgenic mice in vivo
36. Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats
37. Activin betaC and betaE genes are not essential for mous liver growth, differentiation and regeneration
38. Expression of inhibin betaA, betaB and follistatin mRNAs in the carbon tetrachloride induced rat liver regeneration model
39. Diffirential regulation of activin A for hepatocyte growth and fibronectin synthesis in rat liver injury
40. Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury
41. Fifty-seven-kda protein in royal jelly enhances proliferation of primary cultured rat hepatocytes and increases albumin production in the absence of serum
42. The augmenter of liver regeneration induces mitochondrial gene expression in rat liver and enhances oxidative phosphorylation capacity of liver mitochondria
43. Molecular mechanisms of augmenter of liver regeneration as immunomodulator: Its effect on interferon-gamma expression in rat liver
44. Isolation and characterization of a novel liver-specific gene, hepassocin, upregulated during liver regeneration
45. Stimulation of the mitogen-activated protein kinase cascade and tyrosine phosphorylation of the epidermal growth factor receptor by hepatopoietin
46. Hepatic stimulator substance activity in the liver of thioacetamide-intoxicated rats
47. Angiotensin-converting enzyme inhibition by lisinopril enhance liver regeneration in rats
48. The Fn 14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas
49. Repression of TNF-alpha-induced E-selectin expression by PPAR activators: Involvement of transcriptional repressor LRF-1/ATF3
50. Liver regeneration is transiently impaired in urokinase-deficient mice
51. Mechanism of retarded liver regeneration in plasminogen activitor-deficient mice: Impaired activation of hepatocyte growth factor after Fas-mediated massive hepatic apoptosis
52. Early down-regulation of cytochrome P4503A and 2E1 in the regenerating rat liver is not related to the loss of liver mass or the process of cellular proliferation
53. Expression of intracellular calcium channels and pumps after partial hepatectomy in rat
54. KATP channels regulate mitogenically idnuced proliferation in primary rat hepatocytes and human liver cell lines. Implications for liver growth control and potential therapeutic targeting
55. The role of regucalcin in nuclear regulation of regenerating liver
56. Differential suppression of liver-specific genes in regenerating rat liver induced by, extended hepatectomy
57. Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration
58. Metallothionein and heat shock protein expression during acute liver injury and regeneration in rats
59. Poly (ADP-ribose) polymerase is affected early by thyroid state during liver regeneration in rats
60. Liver gene regulation in rats following both 70 or 90% hepatectomy and endotoxin treatment
61. Differential association of p21Cip1 and p27Kip1 with cyclin E-CDK2 during rat liver regeneration
62. Characterization of a nuclear factor that binds to AP1-like element in the rat p53 promoter during liver regeneration
63. Up-regulation of 1-2 (PP2A) / SET gene expression in rat primary heptomas and regenerating livers
64. Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis
65. A Rho-specific exchange factor Ect2 is induced from S to M phases in regenerating mouse liver
66. Premature expression the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase
67. Changes in the Wnt/beta-catenin pathway during regulated growth in rat liver regeneration
68. Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin
69. Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver
70. Fas regulates liver regeneration. Editorial
71. Fas (APO-1/CD 95) mRNA is down-regulated in liver regeneration after hepatectomy in rats
72. Fas engagement accelerates liver regeneration after partial hepatectomy
73. Keratin-dependent, epithelial resistance to tumor neocosis factor-induced apoptosis
74. NF-κB determines between apoptosis and proliferation in hepatocytes during liver regeneration
75. Change in caspase-3-1ike protease in the liver and plasma during rat liver regeneration following partial hepatectomy
76. Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines
77. Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat
78. Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration
79. Regulation and significance of hepatocyte-derived matrix metalloproteinases in liver remodeling
80. Kinetics of expression of connective tissue growth factor gene during liver regeneration after partial hepatectomy and D-galactosamine-induced liver injury in rats
81. Mice deficient in hepsin, a serine protease, exhibit normal embryogenesis and unchanged hepatocyte regeneration ability
82. A novel role of complement: Mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration
83. The role of Kupffer cells in liver regeneration
84. Intense expansion of natural killer T cells in the early phase of hepatocyte regeneration after partial hepatectomy in mice and its association with sympathetic nerve activation
85. Do natural T cells promote liver regeneration? Editorial
86. Augmenter of liver regeneration (ALR) may promote liver regeneration by reducing natural killer (NK) cell activity in human liver diseases
87. Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver
88. Failure of regeneration of the steatotic rat liver: Disruption at two different levels in the regeneration pathway
89. Effects of hepatic blood inflow occlusion on liver regeneration following partial hepatectomy in an experimental model of cirrhosis
90. Effect of portal branch ligation on liver regeneration in the rat
91. Human hepatic stem-like cells isolated using c-kit or CD34 can differentiate into biliary epithelium
92. Morphogenesis of primary biliary epithelial cells: Induction in high-density culture or by coculture with autologous human hepatocytes
93. Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver
94. Repopulation of liver endothelium by bone-marrow-derived cells
95. Tubedown-1, a novel acetyl-transferase associated with blood vessel development
96. Expression and role of vascular endothelial growth factor in liver regeneration after partial hepatectomy in rats
97. Regression of bile duct damage and bile duct proliferation in the non-arterialized transplanted rat liver is associated with spontaneous graft rearterialization
98. Tissue distribution, quantitation and proliferation kinetics of fat-storing cells in carbon tetrachloride-injured rat liver
99. Immunohistochemical detection of proliferating lipocytes in regenerating rat liver
100. The hepatic extracellular matrix
101. CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair
102. Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene
103. Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: Distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair
104. Cells with morpho-logical and immunohistochemical features of hepatic stellate cells (Ito cells) form an extralittoral (extrasinusoidal) compartment in the cirrhotic rat liver
105. Myofibroblasts in the cirrhotic rat liver reflect hepatic remodeling and correlate with fibrosis and sinusoidal capillarization