Myofibroblasts in the cirrhotic rat liver reflect hepatic remodeling and correlate with fibrosis and sinusoidal capillarization

Journal of Hepatology

Volumn 30, Issue 4, 1999, Pages 646-652

  Zimmermann, Arthur ^a   Zhao, Delai ^a   Reichen, J Ürg ^a  

^a NONE

Author keywords

Hepatic fibrogenesis; Hepatic stellate cells; Liver cirrhosis; Multiple indicator dilution technique; Myofibroblasts

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONNECTIVE TISSUE; EXTRAVASCULAR SPACE; FIBRIN FORMATION; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER WEIGHT; MALE; MULTIPLE REGRESSION; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; STELLATE CELL;

EID: 0033061189     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(99)80195-0     Document Type: Article

References (36)

1. Wake K. Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs. Int Rev Cytol. 66:1980;303-353.
2. Sztark F., Dubroca J., Latry P., Quinton A., Balabaud C., Bioulac-Sage P. Perisinusoidal cells in patients with normal liver histology. A morphometric study. J Hepatol. 2:1986;358-369.
3. Gressner A.M. Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis. Kidney Int Suppl. 54:1996;S39-S45.
4. Mathew J., Geerts A., Burt A.D. Pathobiology of hepatic stellate cells. Hepatogastroenterology. 43:1996;72-91.
5. Hautekeete M.L., Geerts A. The hepatic stellate (Ito) cell: its role in human liver disease. Virchows Arch. 430:1997;195-207.
6. Arenson D.M., Friedman S.L., Bissell D.M. Formation of extracellular matrix in normal rat liver: lipocytes as a major source of proteoglycan. Gastroenterology. 95:1988;441-447.
7. Friedman S.L. The cellular basis of hepatic fibrosis: mechanisms and treatment strategies. N Engl J Med. 328:1993;1828-1835.
8. Burt A.D. Cellular and molecular aspects of hepatic fibrosis. J Pathol. 170:1993;105-114.
9. Gressner A.M. Perisinusoidal lipocytes and fibrogenesis. Gut. 35:1994;1331-1333.
10. Senoo H., Imai K., Sato M., Kojima N., Miura M., Hata R. Three-dimensional structure of extracellular matrix reversibly regulates morphology, proliferation and collagen metabolism of perisinusoidal stellate cells (vitamin A-storing cells). Cell Biol Int. 20:1996;501-512.
11. Kawada N. The hepatic perisinusoidal stellate cell. Histol Histopathol. 12:1997;1069-1080.
12. Schaffner F., Popper H. Capillarization of hepatic sinusoids in man. Gastroenterology. 44:1963;239-242.
13. Callea F., Mebis J., Desmet V.J. Myofibroblasts in focal nodular hyperplasia of the liver. Virchows Arch (A). 369:1982;155-166.
14. Callea F., Desmet V.J. Transformation of fat storing cells (Ito cells) to myofibroblasts. [abstract] J Hepatol (Suppl.). 2:1985;206.
15. Burt A.D., Robertson J.L., Heir J., MacSween R.N.M. Desmin-containing stellate cells in rat liver; distribution in normal animals and response to experimental acute liver injury. J Pathol. 150:1986;29-35.
16. Burt A.D., MacSween R.N.M. Immunolocalisation of desmin in fixed rat and human liver. Kirn A., Knook D.L., Wisse E., Cells of the Hepatic Sinusoid. 1986;253-254 The Kupffer Cell Foundation, Vol.1: Proceedings of the 3rd Int Kupffer Cell Symposium held in Strasbourg, Rjiswijk.
17. Takahara T., Kojima T., Miyabayashi C., Inoue K., Sasaki H., Muragaki Y., et al. Collagen production in fat-storing cells after carbon tetrachloride intoxication in the rat. Immunoelectron microscopic observation of type I, type III collagens, and prolyl hydroxylase. Lab Invest. 59:1988;509-521.
18. Yokoi Y., Namihisa T., Matsuzaki K., Miyazaki A., Yamaguchi Y. Distribution of Ito cells in experimental hepatic fibrosis. Liver. 8:1988;48-52.
19. Milani S., Herbst H., Schuppan D., Kim K.Y., Riecken E.O., Stein H. Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis. Gastroenterology. 98:1990;175-184.
20. Nakatsukasa H., Nagy P., Evarts R.P., Hsia C-C, Marsden E., Thorgeirsson S.S. Cellular distribution of transforming growth factorbetal and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis. J Clin Invest. 85:1990;1833-1843.
21. Tanaka Y., Mak K.M., Lieber C.S. Immunohistochemical detection of proliferating lipocytes in regenerating rat liver. J Pathol. 160:1990;129-134.
22. Lory J., Schweizer W., Blumgart L.H., Zimmermann A. The pathology of the atrophy/hypertrophy complex (AHC) of the liver. A light microscopic and immunohistochemical study. Histol Histopath. 9:1994;541-554.
23. Reichen J., Le M. Verapamil favourably influences hepatic microvascular exchange and function in rats with cirrhosis of the liver. J Clin Invest. 78:1986;448-455.
24. Reichen J., Egger B., Ohara N., Zeltner T.B., Zysset T., Zimmermann A. Determinants of hepatic function in liver cirrhosis in the rat. Multivariate analysis. J Clin Invest. 82:1988;2069-2076.
25. Reichen J., Arts B., Schafroth U., Zimmermann A., Zeltner T.B., Zysset T. Aminopyrine N-demethylation by rats with liver cirrhosis: evidence for the intact cell hypothesis. A morphometric-functional study. Gastroenterology. 93:1987;719-726.
26. Cruz-Orive L.M., Weibel E.R. Sampling design for stereology. J Microsc. 122:1981;235-257.
27. Weibel E.R. Stereological Methods. 1979;Academic Press, London.
28. Huet P.M., Goresky C.A., Villeneuve J.P., Marleau D., Lough J.O. Assessment of liver microcirculation in human cirrhosis. J Clin Invest. 70:1982;1234-1244.
29. Varin F., Huet P.M. Hepatic microcirculation in the perfused cirrhotic rat liver. J Clin Invest. 76:1985;1904-1912.
30. Terada T., Makimoto K., Terayama N., Suzuki Y., Nakanuma Y. Alpha-smooth muscle actin-positive stromal cells in cholangi-ocarcinomas, hepatocellular carcinomas and metastatic liver carcinomas. J Hepatol. 24:1996;706-712.
31. Ooi L.P.J., Crawford D.H.G., Gotley D.C., Clouston A.D., Strong R.W., Gobé G.C., et al. Evidence that"myofibroblast-like" cells are the cellular source of capsular collagen in hepatocellular carcinoma. J Hepatol. 26:1997;798-807.
32. Barrowman J.A. Hepatic lymph and lymphatics. McIntyre N., Benhamou J.P., Bircher J., Rizzetto M., Rodes J., Oxford Textbook of Clinical Hepatology, Vol. 1. 1991;37-40 Oxford University Press, Oxford.
33. Hardonk M.J., Armosoerodjo-Briggs J. Evidence for the anatomical connection between the space of Disse and the portal tract in human and rat liver. Knook D.L., Wisse E., Cells of the Hepatic Sinusoid, Vol. 4. 1993;182-184 Kupffer Cell Foundation, Leiden, The Netherlands.
34. Vollmar B., Wolf B., Siegmund S., Katsen A.D., Menger M.D. Lymph vessel expansion and function in the development of hepatic fibrosis and cirrhosis. Am J Pathol. 151:1997;169-175.
35. Bircher J., Blankart R., Halpern A., Haecki W., Laissue J., Preisig R. Criteria for assessment of functional impairment in patients with cirrhosis of the liver. Eur J Clin Invest. 3:1973;72-85.
36. Burt A.D., MacSween R.N.M. Bile duct proliferation - its true significance? Histopathology. 23:1993;599-602.