Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer

Molecular and Cellular Biology

Volumn 19, Issue 7, 1999, Pages 5143-5154

  Abreu Martin, Maria T ^b   Chari, Ajai ^a   Palladino, Andrew A ^b   Craft, Noah A ^a   Sawyers, Charles L ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c Box 951678 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ESTROGEN RECEPTOR; METRIBOLONE; MITOGEN ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; GENE CONTROL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0032999345     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.7.5143     Document Type: Article

References (59)

1. Abreu-Martin, M. T., and C. L. Sawyers. Unpublished data.
2. Amati, B., and H. Land. 1994. Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death. Curr. Opin. Genet. Dev. 4:102-108.
3. Brandstrom, A., P. Westin, A. Bergh, S. Cajander, and J. E. Damber. 1994. Castration induces apoptosis in the ventral prostate but not in an androgen-sensitive prostatic adenocarcinoma in the rat. Cancer Res. 54:3594-3601.
4. Bubulya, A., S. C. Wise, X. Q. Shen, L. A. Burmeister, and L. Shemshedini. 1996. c-Jun can mediate androgen receptor-induced transactivation. J. Biol. Chem. 271:24583-24589.
5. Bunone, G., P. A. Briand, R. J. Miksicek, and D. Picard. 1996. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J. 15:2174-2183.
6. Cardone, M. H., G. S. Salvesen, C. Widmann, G. Johnson, and S. M. Frisch. 1997. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90:315-323.
7. Chen, Y. R., X. Wang, D. Templeton, R. J. Davis, and T. H. Tan. 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271:31929-31936.
8. Cleutjens, K. B., H. A. van der Korput, C. C. van Eekelen, H. C. J. van Rooij, P. W. Faber, and J. Trapman. 1997. An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter. Mol. Endocrinol. 11:148-161.
9. Cleutjens, K. B., C. C. van Eekelen, H. A. van der Korput, A. O. Brinkmann, and J. Trapman. 1996. Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter. J. Biol. Chem. 271:6379-6388.
10. Colombel, M., S. Gil Diez, F. Radvanyi, R. Buttyan, J. P. Thiery, and D. Chopin. 1996. Apoptosis in prostate cancer. Molecular basis to study hormone refractory mechanisms. Ann. N. Y. Acad. Sci. 784:63-69.
11. Craft, N., Y. Shostak, M. Carey, and C. L. Sawyers. 1999. A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat. Med. 5:280-285.
12. Culig, Z., A. Hobisch, M. V. Cronauer, C. Radmayr, J. Trapman, A. Hittmair, G. Bartsch, and H. Klocker. 1994. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res. 54:5474-5478.
13. Deak, J. C., J. V. Cross, M. Lewis, Y. Qian, L. A. Parrott, C. W. Distelhorst, and D. J. Templeton. 1998. Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1. Proc. Natl. Acad. Sci. USA 95:5595-5600.
14. Derijard, B., M. Hibi, I. H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R. J. Davis. 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037.
15. Dickens, M., J. S. Rogers, J. Cavanagh, A. Raitano, Z. Xia, J. R. Halpern, M. E. Greenberg, C. L. Sawyers, and R. J. Davis. 1997. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277:693-696.
16. Fanger, G. R., C. Widmann, A. C. Porter, S. Sather, G. L. Johnson, and R. R. Vaillancourt. 1998. 14-3-3 proteins interact with specific MEK kinases. J. Biol. Chem. 273:3476-3483.
17. Faris, M., N. Kokot, K. Latinis, S. Kasibhatla, D. R. Green, G. A. Koretzky, and A. Nel. 1998. The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by upregulating Fas ligand expression. J. Immunol. 160:134-144.
18. Feng, Z., A. Marti, B. Jehn, H. J. Altermatt, G. Chicaiza, and R. Jaggi. 1995. Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland. J. Cell Biol. 131:1095-1103.
19. Frisch, S. M., K. Vuori, D. Kelaita, and S. Sicks. 1996. A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA. J. Cell Biol. 135:1377-1382.
20. Gadducci, A., and A. R. Genazzani. 1997. Steroid hormones in endometrial and breast cancer. Eur. J. Gynaecol. Oncol. 18:371-378. (Review.)
21. Garnick, M., and W. Fair. 1996. Prostate cancer: emerging concepts. Part II. Ann. Intern. Med. 125:205-212.
22. Helmberg, A., N. Auphan, C. Caelles, and M. Karin. 1995. Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J. 14:452-460.
23. Hong, H., K. Kohli, A. Trivedi, D. L. Johnson, and M. R. Stallcup. 1996. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc. Natl. Acad. Sci. USA 93:4948-4952.
24. Ikonen, T., J. J. Palvimo, P. J. Kallio, P. Reinikainen, and O. A. Janne. 1994. Stimulation of androgen-regulated transactivation by modulators of protein phosphorylation. Endocrinology 135:1359-1366.
25. Jenster, G., P. E. de Ruiter, H. A. van der Korput, G. G. Kuiper, J. Trapman, and A. O. Brinkmann. 1994. Changes in the abundance of androgen receptor isotypes: effects of ligand treatment, glutamine-stretch variation, and mutation of putative phosphorylation sites. Biochemistry 33:14064-14072.
26. Johnson, N. L., A. M. Gardner, K. M. Diener, C. A. Lange-Carter, J. Gleavy, M. B. Jarpe, A. Minden, M. Karin, L. I. Zon, and G. L. Johnson. 1996. Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J. Biol. Chem. 271:3229-3237.
27. Karin, M. 1998. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell 93:487-490.
28. Kato, S., H. Endoh, Y. Masuhiro, T. Kitamoto, S. Uchiyama, H. Sasaki, S. Masushige, Y. Gotoh, E. Nishida, H. Kawashima, et al. 1995. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270:1491-1494.
29. Kitsberg, D. I., and P. Leder. 1996. Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice. Oncogene 13:2507-2515.
30. Klein, K. A., R. E. Reiter, J. Redula, H. Moradi, X. L. Zhu, A. R. Brothman, D. J. Lamb, M. Marcelli, A. Belldegrun, O. N. Witte, and C. L. Sawyers. 1997. Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice. Nat. Med. 3:402-408.
31. Lee, F. S., J. Hagler, Z. J. Chen, and T. Maniatis. 1997. Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213-222.
32. Lehman, A. M., K. B. Ellwood, B. E. Middleton, and M. Carey. 1998. Compensatory energetic relationships between upstream activators and the RNA polymerase II general transcription machinery. J. Biol. Chem. 273: 932-939.
33. Lim, D. J., X. L. Liu, D. M. Sutkowski, E. J. Braun, C. Lee, and J. M. Kozlowski. 1993. Growth of an androgen-sensitive human prostate cancer cell line, LNCaP, in nude mice. Prostate 22:109-118.
34. Marcelli, M., S. J. Haidacher, S. R. Plymate, and R. S. Birnbaum. 1995. Altered growth and insulin-like growth factor-binding protein-3 production in PC3 prostate carcinoma cells stably transfected with a constitutively active androgen receptor complementary deoxyribonucleic acid. Endocrinology 136:1040-1048.
35. Marcelli, M., W. Tilley, C. Wilson, J. Griffin, J. Wilson, and M. McPhaul. 1990. Definition of the human androgen receptor gene structure permits the identification of mutations that cause androgen resistance: premature termination of the receptor protein at amino acid residue 588 causes complete androgen resistance. Mol. Endocrinol. 4:1105-1116.
36. McConkey, D. J., G. Greene, and C. A. Pettaway. 1996. Apoptosis resistance increases with metastatic potential in cells of the human LNCaP prostate carcinoma line. Cancer Res. 56:5594-5599.
37. Minden, A., A. Lin, M. McMahon, C. Lange-Carter, B. Derijard, R. J. Davis, G. L. Johnson, and M. Karin. 1994. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK Science 266:1719-1723.
38. Nakano, H., M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and K. Okumura. 1998. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA 95:3537-3542.
39. Nazareth, L. V., and N. L. Weigel. 1996. Activation of the human androgen receptor through a protein kinase A signaling pathway. J. Biol. Chem. 271: 19900-19907.
40. Pang, S., J. Dannull, R. Kaboo, Y. Xie, C.-L. Tso, K. Michel, J. B. deKernion, and A. S. Belldegrun. 1997. Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen. Cancer Res. 57:495-499.
41. Prins, G. S., R. J. Sklarew, and L. P. Pertschuk. 1998. Image analysis of androgen receptor immunostaining in prostate cancer accurately predicts response to hormonal therapy. J. Urol. 159:641-649.
42. Raitano, A. B., J. R. Halpern, T. M. Hambuch, and C. L. Sawyers. 1995. The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation. Proc. Natl. Acad. Sci. USA 92:11746-11750.
43. Reinikainen, P., J. J. Palvimo, and O. A. Janne. 1996. Effects of mitogens on androgen receptor-mediated transactivation. Endocrinology 137:4351-4357.
44. Sato, N., M. D. Sadar, N. Bruchovsky, F. Saatcioglu, P. S. Rennie, S. Sato, P. H. Lange, and M. E. Cleave. 1997. Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP. J. Biol. Chem. 272:17485-17494.
45. Schurr, E. R., G. A. Henderson, L. A. Kmetec, J. D. Miller, H. G. Lamparski, and D. R. Henderson. 1996. Prostate-specific antigen expression is regulated by an upstream enhancer. J. Biol. Chem. 271:7043-7051.
46. Shi, Y., J. M. Glynn, L. J. Guilbert, T. G. Cotter, R. P. Bissonnette, and D. R. Green. 1992. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 257:212-214.
47. Sun, Z., J. Pan, and S. P. Balk. 1997. Androgen receptor-associated protein complex binds upstream of the androgen-responsive elements in the promoters of human prostate-specific antigen and kallikrein 2 genes. Nucleic Acids Res. 25:3318-3325.
48. Tang, D. G., and A. T. Porter. 1997. Target to apoptosis: a hopeful weapon for prostate cancer. Prostate 32:284-293.
49. van Steenbrugge, G., C. van Uffelen, J. Bolt, and F. Schroder. 1991. The human prostatic cancer cell line LNCaP and its derived sublines: an in vitro model for the study of androgen sensitivity. J. Steroid Biochem. Mol. Biol. 40:207-214.
50. Veldscholte, J., C. Berrevoets, C. Ris-Stalpers, G. Kuiper, G. Jenster, J. Trapman, A. Brinkmann, and E. Mulder. 1992. The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to anti-androgens. J. Steroid Biochem. Mol. Biol. 41:665-669.
51. Widmann, C., S. Gibson, and G. L. Johnson. 1998. Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals. J. Biol. Chem. 273:7141-7147.
52. Widmann, C., N. L. Johnson, A. M. Gardner, R. J. Smith, and G. L. Johnson. 1997. Potentiation of apoptosis by low dose stress stimuli in cells expressing activated MEK kinase 1. Oncogene 15:2439-2447.
53. Wise, S. C., L. A. Burmeister, X.-F. Zhou, A. Bubulya, J. L. Oberfield, M. J. Birrer, and L. Shemshedini. 1998. Identification of domains of c-jun mediating androgen receptor transactivation. Oncogene 16:2001-2009.
54. Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331.
55. Xu, S, and M. H. Cobb. 1997. MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J. Biol. Chem. 272:32056-32060.
56. 70, for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. USA 93:5517-5521.
57. Yin, M. J., L. B. Christerson, Y. Yamamoto, Y. T. Kwak, S. Xu, F. Mercurio, M. Barbosa, M. H. Cobb, and R. B. Gaynor. 1998. HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation. Cell 93:875-884.
58. Zhou, Q., J. F. Krebs, S. J. Snipas, A. Price, E. S. Alnemri, K. J. Tomaselli, and G. S. Salvesen. 1998. Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex. Biochemistry 37:10757-10765.
59. Zhu, X., and J. P. Liu. 1997. Steroid-independent activation of androgen receptor in androgen-independent prostate cancer: a possible role for the MAP kinase signal transduction pathway? Mol. Cell. Endocrinol. 134:9-14.