Anaphylatoxin C5a actions in rat liver: Synergistic enhancement by C5a of lipopolysaccharide-dependent α2-macroglobulin gene expression in hepatocytes via IL-6 release from Kupffer cells

Journal of Immunology

Volumn 167, Issue 7, 2001, Pages 3972-3979

  Mack C ^a   Jungermann, K ^a   Gotze O ^a   Schieferdecker, H L ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; ANAPHYLATOXIN; COMPLEMENT COMPONENT C5A [DEARGININE]; INTERLEUKIN 6; LIPOPOLYSACCHARIDE;

ACUTE PHASE RESPONSE; ANIMAL CELL; ARTICLE; COMPLEMENT ACTIVATION; IMMUNITY; IMMUNOREGULATION; KUPFFER CELL; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0035478955     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.7.3972     Document Type: Article

References (57)

1. Fifth component of human complement: Purification from plasma and polypeptide chain structure
2. Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin: Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a
3. Primary structure and functional characterization of rat C5a: An anaphylatoxin with unusually high potency
4. Nucleotide and corrected amino acid sequence of the functional recombinant rat anaphylatoxin C5a
5. Complement - Biologically active products
6. Biochemistry and biology of anaphylatoxins
7. The role of complement in inflammation and phagocytosis
8. The alternative pathway of complement
9. Quantitative determination of complement components produced by purified hepatocytes
10. Biosynthesis of complement components by cultured rat hepatocytes
11. Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver
12. 2+ release
13. Eicosanoid-mediated increase in glucose and lactate output as well as decrease and redistribution of flow by complement activated rat serum in perfused rat liver
14. Inhibition of anaphylatoxin C3a- and C5a- but not nerve stimulation- or noradrenaline-dependent increase in glucose output and reduction of flow in Kupffer cell-depleted perfused rat livers
15. 2 on hepatocytes
16. Stimulation of glycogen phosphorylase in rat hepatocytes via prostanoid release from Kupffer cells by recombinant rat anaphylatoxin C5a but not by native human C5a in hepatocyte/Kupffer cell co-cultures
17. Stimulation by anaphylatoxin C5a of glycogen phosphorylase in rat hepatocytes via prostanoid release from hepatic stellate cells but not sinusoidal endothelial cells
18. The acute phase response
19. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes
20. Interleukin-6 and the acute phase response
21. Cytokines and the hepatic acute-phase response
22. Biologically active products of stimulated liver macrophages (Kupffer cells)
23. Centrifugal separation of mammalian cells
24. Rat hepatocytes prepared with collagenase: Prolonged retention of differentiated characteristics in culture
25. 2-mediated and noradrenaline-mediated but not glucagon-mediated activation of glycogenolysis in rat liver
26. Sequence of rat liver α-2-macroglobulin and acute phase control of its messenger RNA
27. Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: Role of epidermal growth factor and perivenous oxygen tension
28. Molecular cloning and expression of the functional rat C5a receptor
29. A sensitive ELISA for the quantification of human C5a in blood plasma using a monoclonal antibody
30. Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock
31. The role of C5a in interleukin-6 production induced by lipopolysaccharide or interleukin-1
32. Human recombinant C5a enhances lipopolysaccharide-induced synthesis of interleukin-6 by human monocytes
33. C5a-mediated release of interleukin 6 by human monocytes
34. C5a induction of human interleukin 1: Synergistic effect with endotoxin or interferon-γ
35. Recombinant C5a enhances interleukin 1 and tumor necrosis factor release by lipopolysaccharide-stimulated monocytes and macrophages
36. Generation of biologically active IL-1Β by matrix metalloproteinases: A novel caspase-1-independent pathway of IL-1Β processing
37. Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells
38. Activation of the gene for the type-1 acute phase protein hemopexin in hepatocytes by Kupffer cell-derived IL-6 but not IL-1Β following stimulation with C5a or LPS: Lack of post-translational processing of IL-1Β
39. The chemotactic receptor for human C5a anaphylatoxin
40. Molecular cloning and expression of the functional rat C5a receptor
41. Specific interactions of chemoattractant factor receptors with G-proteins
42. Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor
43. NF-κB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells
44. Different sensitivities of the responses of human neutrophils stimulated with immune complex and C5a anaphylatoxin to pertussis toxin
45. Interaction between the C5a receptor and Gi in both the membrane-bound and detergent-solubilized states
46. The human chemoattractant complement C5a receptor inhibits cyclic AMP accumulation through Gi and Gz proteins
47. Molecular mechanisms of endotoxin activity
48. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
49. Toll-like receptor-4 mediates lipopolysacchadde-induced signal transduction
50. LPS-mediated NFκB activation in rat Kupffer cells can be induced independently of CD14
51. Regulation of synthesis of major rat acute-phase proteins by recombinant human interleukin-6 (BSF/IL-6) in hepatocyte primary cultures
52. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
53. Interleukin-6-induced serine phosphorylation of transcription factor APRF: Evidence for a role in interleukin-6 target gene induction
54. Cytokines and the hepatic acute-phase response
55. Cell-specific expression of hepatocyte growth factor in liver: Upregulation in sinusoidal endothelial cells after carbon tetrachloride
56. Hepatocyte growth factor and retinoic acid exert opposite effects on synthesis of type 1 and type 2 acute phase proteins in rat hepatoma cells