The GABAB antagonist CGP56433A attenuates the effect of baclofen on cocaine but not heroin self-administration in the rat

Psychopharmacology

Volumn 160, Issue 1, 2002, Pages 49-55

  Brebner, Karen ^a,c   Froestl, Wolfgang ^b,c   Roberts, David C ^a,c  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Agonist; Baclofen; CGP56433A; Cocaine; GABA; Heroin; Self administration

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; BACLOFEN; CGP 56433A; COCAINE; DIAMORPHINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; LIGAND BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; REINFORCEMENT; SELF INJECTION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BACLOFEN; BENZOIC ACIDS; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; GABA AGONISTS; GABA ANTAGONISTS; HEROIN DEPENDENCE; MALE; PHOSPHINIC ACIDS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-B; REINFORCEMENT SCHEDULE; SELF ADMINISTRATION;

EID: 0036176034     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-001-0952-7     Document Type: Article

References (34)

1. Ability of baclofen in reducing alcohol craving and intake: II-preliminary clinical evidence
2. Double-blind randomized controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal
3. B receptors play a role in the development of tolerance to ethanol in mice
4. B receptor heterodimer-component localization in human brain
5. BR1 receptor mRNA and binding sites in the rat brain
6. The GABA(B) agonist CGP 44532 decreases cocaine self-administration in rats: Demonstration using a progressive ratio and a discrete trials procedure
7. Effect of baclofen on cocaine self-administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules
8. Intra-VTA baclofen attenuates cocaine self-administration on a progressive ratio schedule of reinforcement
9. Effects of baclofen on maintenance and reinstatement of intravenous cocaine self-administration in rats
10. Response of nicotine self-administration in the rat to manipulations of mu-opioid and gamma-aminobutyric acid receptors in the ventral tegmental area
11. B antagonists
12. B receptor antagonists
13. Gamma-vinyl-gamma-amino-butyric acid attenuates the synergistic elevations of nucleus accumbens dopamine produced by a cocaine/heroin (speed-ball) challenge
14. B receptor antagonists on learning and memory retention in a rat model of absence epilepsy
15. B receptor antagonism on the development of pentylenetetrazol-induced kindling in mice
16. B receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) but not neurotrophin-3 (NT-3) in brain and spinal cord of rats
17. Opioids excite dopamine neurons by hyperpolarization of local interneurons
18. Neurotransmitter regulation of dopamine neurons in the ventral tegmental area
19. Modulation of A10 dopamine neurons by gamma-aminobutyric acid agonists
20. Cellular and molecular mechanisms of drug dependence
21. Baclofen as a cocaine anti-craving medication: A preliminary clinical study
22. B receptor agonist and antagonists decreased brain stimulation reward in the rat
23. The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat
24. Progressive ratio schedules in drug self-administration studies in rats: A method to evaluate reinforcing efficacy
25. Baclofen suppression of cocaine self-administration: Demonstration using a discrete trials procedure
26. GABA modulation of cocaine self-administration
27. Drug self-administration: Experimental methods and determinants
28. Baclofen attenuates the reinforcing effects of cocaine in rats
29. B agonist baclofen modifies cocaine self-administration in rats
30. Outcomes when using the GABA-B agonist baclofen in human cocaine users
31. Eating induced dopamine release from mesolimbic neurons is mediated by NMDA receptors in the ventral tegmental area: A dual probe microdialysis study
32. Addictive drugs and brain stimulation reward
33. Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release
34. Opposite changes in the mesolimbic dopamine metabolism in the nerve terminal and cell body sites induced by locally infused baclofen in the rat