Ability of baclofen in reducing alcohol craving and intake: II - Preliminary clinical evidence

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 1, 2000, Pages 67-71

  Addolorato, Giovanni ^b   Caputo, Fabio ^c   Capristo, Esmeralda ^c   Colombo, Giancarlo ^a   Gessa, Gian Luigi ^c   Gasbarrini, Giovanni ^c  

^a CNR   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c NONE

Author keywords

Alcoholism; Baclofen; Craving; Obsessional Thinking; Pharmacological Treatment for Alcohol Addiction

Indexed keywords

BACLOFEN;

ABDOMINAL PAIN; ABSTINENCE; ADULT; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ARTICLE; CLINICAL ARTICLE; CONSTIPATION; DIARRHEA; DRUG EFFICACY; DRUG TOLERABILITY; FOLLOW UP; HEADACHE; HUMAN; HYPOTENSION; MALE; NAUSEA; PRIORITY JOURNAL; SCORING SYSTEM; SELF EVALUATION; TREATMENT OUTCOME; VERTIGO;

EID: 0033956440     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000374-200001000-00011     Document Type: Article

References (41)

1. Addolorato G, Balducci P, Capristo E, Attilia ML, Taggi F, Gasbarrini G, Ceccanti M (1999b) Gamma-hydroxybutyric acid (GHB) in the treatment of alcohol withdrawal syndrome: A randomized comparative study versus benzodiazepine. Alcohol Clin Exp Res 23:1596-1604.
2. Addolorato G, Caputo F, Capristo E, Bernardi M, Stefanini GF, Gasbarrini G (1999c) A case of gamma-hydroxybutyric acid withdrawal syndrome during alcohol addiction treatment: Utility of diazepam administration. Clin Neuropharmacol 22:60-62.
3. Addolorato G, Caputo F, Capristo E, Stefanini GF, Gasbarrini G (1999a) Gamma-hydroxybutyric acid: Efficacy, potential abuse and dependence in the treatment of alcohol addiction. Alcohol, in press.
4. Addolorato G, Caputo F, Stefanini GF, Gasbarrini G (1997) Gamma-hydroxybutyric acid in the treatment of alcohol dependence: Possible craving development for the drug. Addiction 92:1041-1042.
5. Addolorato G, Castelli E, Stefanini GF, Casella G, Caputo F, Marsigli L, Bernardi M, Gasbarrini G (1996) An open multicentric study evaluating 4-hydroxybutyric acid sodium salt in the medium-term treatment of 179 alcohol dependent subjects. Alcohol Alcohol 31:341-345.
6. Addolorato G, Cibin M, Capristo E, Beghé F, Gessa GL, Stefanini GF, Gasbarrini G (1998a) Maintaining abstinence from alcohol by gamma-hydroxybutyric acid. Lancet 351:38.
7. Addolorato G, Cibin M, Caputo F, Capristo E, Gessa GL, Stefanini GF, Gasbarrini G (1998b) Gamma-hydroxybutyric acid in the treatment of alcoholism: Dosage fractioning utility in non-responder alcoholic patients. Drug Alcohol Depend 53:7-10.
8. Addolorato G, Viaggi M, Gentilini L, Castelli E, Nicastro P, Stefanini GF, Gasbarrini G (1993) Alcohol addiction: Evaluation of the therapeutic effectiveness of self-managed self-help group in the maintenance of abstinence from alcohol. Alcologia Eur J Alcohol Stud 5:261-263.
9. Agabio R, Colombo G, Loche A, Lobina C, Pani L, Reali R, Gessa GL (1998) Gamma-hydroxybutyric acid reducing effect on ethanol intake: Evidence in favour of a substitution mechanism. Alcohol Alcohol 33: 465-474.
10. Allan AM, Harris A (1989) A new alcohol antagonist: Phaclofen. Life Sci 45:1771-1779.
11. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders. 4th ed. American Psychiatric Association, Washington, DC.
12. Anton RF (1996) Neurobehavioural basis for the pharmacotherapy of alcoholism: Current and future directions. Alcohol Alcohol 31(Suppl 1):43-53.
13. Colombo G, Agabio R, Carai MAM, Lobina C, Pani M, Reali R, Addolorato G, Gessa GL (2000) Ability of baclofen in reducing alcohol intake and withdrawal severity: I - Preclinical evidence. Alcohol Clin Exp Res 24:58-66.
14. Colombo G, Agabio R, Lobina C, Reali R, Fadda F, Gessa GL (1995) Symmetrical generalization between the discriminative stimulus effects of gamma-hydroxybutyric acid and ethanol: Occurrence within narrow dose ranges. Physiol Behav 57:105-111.
15. B receptors in the mediation of discriminative stimulus effects of gamma-hydroxybutyric acid. Physiol Behav 64:293-302.
16. Dall'Aglio C, Caputo F, Baudanza P, Castelli E, Marsigli L, Moscatello M, Addolorato G, Stefanini GF (1997) Short and long-term treatment of alcohol dependence. Alcologia Eur J Alcohol Stud 9:61-64.
17. Daoust M, Saligaut C, Lhuintre JP, Moore N, Flipo JL, Boismare F (1987) GABA transmission, but not benzodiazepine receptor stimulation, modulates ethanol intake by rats. Alcohol 4:469-472.
18. Davidoff RA (1985) Antispasticity drugs: Mechanisms of action. Ann Neurol 17:107-116.
19. Davidson KM (1995) Diagnosis of depression in alcohol dependence: Changes in prevalence with drinking status. Br J Psychiatry 166:199-204.
20. Edwards AGK, Rollnick S (1997) Outcome studies of brief alcohol intervention in general practice: The problem of lost subjects. Addiction 92:1699-1704.
21. Erickson CK (1996) Review of neurotransmitters and their role in alcoholism treatment. Alcohol Alcohol 31(Suppl 1):5-11.
22. Fadda F, Mosca E, Colombo G, Gessa GL (1989) Suppression by gamma-hydroxybutyric acid of ethanol withdrawal syndrome in rats. Alcohol Alcohol 24:447-451.
23. Gallimberti L, Canton G, Gentile N, Cibin M, Ferri M, Ferrara SD, Fadda F, Gessa GL (1989) Gamma-hydroxybutyric acid for the treatment of alcohol withdrawal syndrome. Lancet ii:787-789.
24. Gallimberti L, Ferri M, Ferrara SD, Fadda F, Gessa GL (1992) Gamma-hydroxybutyric acid in the treatment of alcohol dependence: A double blind study. Alcohol Clin Exp Res 16:673-676.
25. Gessa GL, Agabio R, Carai MAM, Lobina C, Pani M, Reali R, Colombo G (1999) Mechanism of the anti-alcohol effect of gamma-hydroxybutyric acid (GHB). Alcohol, in press.
26. Grant BF, Harford TC (1995) Comorbidity between DSM-IV alcohol use disorders and major depression: Results of a national survey. Drug Alcohol Depend 39:197-206.
27. Helzer JE, Pryzbeck TR (1988) The co-occurrence of alcoholism with other psychiatric disorders in the general population and its impact on treatment. J Stud Alcohol 49:219-224.
28. Kessler RC, Crum RM, Warner LA, Nelson CB, Schulenberg J, Anthony JC (1997) Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Arch Gen Psychiatry 54:313-321.
29. Kessler RC, Gonagle KA, Shanyang Z (1994) Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: Results from the National Comorbidity Survey. Arch Gen Psychiatry 51:8-19.
30. Kranzler HR, Anton RF (1994) Implications of recent neuropsychopharmacologic research for understanding the etiology and development of alcoholism. J Consult Clin Psychol 62:1116-1126.
31. Krupitsky EM, Burakov AM, Ivanov VB, Krandashova GF, Lapin IP, Grienko AJ, Borodkin YS (1993) Baclofen administration for the treatment of affective disorders in alcoholic patients. Drug Alcohol Depend 33:157-163.
32. Ling W, Shoptaw S (1998) Baclofen as a cocaine anti-craving medication: A preliminary clinical study. Neuropsychopharmacology 18:403-404.
33. Naranjo CA, Poulos CX, Bremner KE, Lantcot KL (1994) Fluoxetine attenuates alcohol intake and desire to drink. Int Clin Psychopharmacol 9:163-172.
34. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B (1992) Naltrexone and coping skills therapy for alcohol dependence: A controlled study. Arch Gen Psychiatry 49:881-887.
35. Petry NM (1997) Benzodiazepine-GABA modulation of concurrent ethanol and sucrose reinforcement in the rat. Exp Clin Psychopharmacol 5:183-194.
36. Secretary of Health and Human Services (1997) Ninth Special Report to the U.S. Congress on Alcohol and Health (NIH publication 97-4017). U.S. Government Printing Office, Washington, DC.
37. Smith BR, Robidoux J, Amit Z (1992) GABAergic involvement in the acquisition of voluntary ethanol intake in laboratory rats. Alcohol Alcohol 27:227-231.
38. Swift RM (1999) Drug therapy for alcohol dependence. N Engl J Med 340:1482-1490.
39. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP (1992) Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49:876-880.
40. Whitworth AB, Fischer F, Lesch OM, Nimmerrichter A, Oberbauer H, Platz T, Potgieter A, Walter H, Fleischhacker WW (1996) Comparison of acamprosate and placebo in long-term treatment of alcohol dependence. Lancet 347:1438-1442.
41. Yoshida M, Yokoo H, Tanaka T, Emoto H, Tanaka M (1994) Opposite changes in the mesolimbic metabolism in the nerve terminal and cell body sites induced by locally infused in the rat. Brain Res 636:111-114.