Effects of GABA(B) receptor antagonists on learning and memory retention in a rat model of absence epilepsy

European Journal of Pharmacology

Volumn 320, Issue 1, 1997, Pages 9-13

  Getova, Damianka ^b   Bowery, Norman G ^a   Spassov, Vasil ^c  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b MEDICAL UNIVERSITY OF PLOVDIV   (Bulgaria)

^c High Medical School   (Bulgaria)

Author keywords

Absence epilepsy; Cognition; GABA(B) receptor antagonism; GAERS (genetic absence epilepsy rat of Strasbourg)

Indexed keywords

3 [1 [3 [(CYCLOHEXYLMETHYL)HYDROXYPHOSPHINYL] 2 HYDROXYPROPYLAMINO]ETHYL]BENZOIC ACID; 3 AMINOPROPYLBUTYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; CGP 61334; UNCLASSIFIED DRUG; (3 (1 ((3 (CYCLOHEXYLMETHYL)HYDROXYPHOSPHINYL) 2 HYDROXYPROPYL)AMINO)ETHYL)BENZOIC ACID; (3 AMINOPROPYL)(N BUTYL)PHOSPHINIC ACID; (3-(1-((3-(CYCLOHEXYLMETHYL)HYDROXYPHOSPHINYL)-2-HYDROXYPROPYL)AMINO)ETHYL)BENZOIC ACID; (3-AMINOPROPYL)(N-BUTYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; BENZOIC ACID DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; PHOSPHINIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; CONTROLLED STUDY; EPILEPSY; INTRAPERITONEAL DRUG ADMINISTRATION; LEARNING; MALE; MEMORY CONSOLIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; ABSENCE; ANIMAL; AVOIDANCE BEHAVIOR; DRUG ANTAGONISM; DRUG EFFECT; PATHOPHYSIOLOGY; RAT STRAIN; REACTION TIME; REINFORCEMENT; WISTAR RAT;

ANIMALS; AVOIDANCE LEARNING; BENZOATES; BENZOIC ACIDS; EPILEPSY, ABSENCE; GABA ANTAGONISTS; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHINIC ACIDS; RATS; RATS, INBRED STRAINS; RATS, WISTAR; REACTION TIME; RECEPTORS, GABA-B; REINFORCEMENT (PSYCHOLOGY);

EID: 0030614923     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00877-1     Document Type: Article

References (18)

1. B receptors may increase excitatory amino acid mediated neurotransmission, Pharmacol. Commun. 2, 28.
2. Coulter, D.A., J.R. Huguenard and D.A. Prince, 1990, Cellular actions of petit mal anticonvulsant: implication of thalamic low-threshold calcium current in generation of spike-wave discharge, in: Generalised Epilepsy: Neurobiological Approaches, eds. M. Avoli, P. Gloor, P. Kostopoulous and R. Naquet (Birkhäuser, Boston, MA) p. 425.
3. B receptors in excitation and inhibition of thalamocortical cells, Trends Neurosci. 14, 16.
4. B modulators, in: The GABA Receptors, eds. S.J. Enna and N.G. Bowery (Humana Press, Totowa, NJ) p. 271.
5. Gloor, P. and R.G. Fariello, 1988, Generalized epilepsy: some of its cellular mechanisms differ from those of focal epilepsy, Trends Neurosci. 11, 63.
6. Gozzani, J.L. and I. Izquierdo, 1976, Possible peripheral adrenergic and central dopaminergic influence in memory consolidation, Psychopharmacology 49, 109.
7. Lennox, W.G. and M.A. Lennox, 1960, Epilepsy and Related Disorders, Vol. 1 (Little Brown, Boston, MA).
8. Liu, Z., M., Vergnes, A. Depaulis and C. Marescaux, 1991, Evidence of a critical role of GABAergic transmission within the thalamus in the genesis and control of absence seizures in the rat, Brain Res. 545, 1.
9. Marescaux, C., M. Vergnes and A. Depaulis, 1992a, Genetic absence epilepsy in rats from Strasbourg - a review, J. Neural Transm. (Suppl.) 35, 37.
10. B receptor antagonists: potential new anti-absence drugs, J. Neural Transm. (Suppl.) 35, 179.
11. Mondadori, C., 1995, The pharmacology of long-term memory, Eur. Rev. 3, 35.
12. B blocker improves the cognitive performance of mice, rats and rhesus monkey. Behav. Neural. Biol. 60, 62.
13. B antagonist, facilitates memory in a social recognition test in rats, Behav. Brain Res. 77, 227.
14. Snead, O.C., 1988, γ-Hydroxybutyrate model of generalized absence seizures: further characterization and comparison with other absence models, Epilepsia 29, 361.
15. B receptor mediated mechanisms in experimental absence seizures in rat, Pharmacol. Commun. 2(1-2), 63.
16. Snead, O.C., 1995, Basic mechanisms of generalized absence seizure, Ann. Neurol. 37, 146.
17. Vergnes, M., C. Marescaux, G. Micheletti, J. Reis, A. Depaulis, L. Rumback and J.M. Water, 1982, Spontaneous paroxysmal electroclinical patterns in rat: a model of generalized non-convulsive epilepsy, Neurosci. Lett. 33, 97.
18. Vergnes, M., C. Marescaux, A. Boehrer and A. Depaulis, 1991, Are rats with genetic absence epilepsy behaviorally impaired?, Epilepsy Res. 9, 97.