The effects of GABAB agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat

Pain

Volumn 90, Issue 3, 2001, Pages 217-226

  Patel, Sadhana ^a   Naeem, Sami ^a   Kesingland, Adam ^a   Froestl, Wolfgang ^a   Capogna, Marco ^a   Urban, Laszlo ^a   Fox, Alyson ^a  

^a Novatis Inst for Medical Sciences   (United Kingdom)

Author keywords

GABAB receptors; Gabapentin; Neuropathic pain; Spinal cord

Indexed keywords

3 AMINOPROPYL(METHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BACLOFEN; CAPSAICIN; CGP 56433A; FREUND ADJUVANT; GABAPENTIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG INHIBITION; DRUG POTENCY; EVOKED RESPONSE; EXPERIMENTAL LIGATION; HYPERALGESIA; MOTOR COORDINATION; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPASMOLYSIS; SPINAL CORD; SPINAL CORD POTENTIAL;

ACETIC ACIDS; AMINES; ANALGESICS; ANIMALS; BACLOFEN; CYCLOHEXANECARBOXYLIC ACIDS; ELECTRIC STIMULATION; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; HYPERALGESIA; INFLAMMATION; NEURALGIA; RATS; RATS, WISTAR; SPINAL NERVE ROOTS;

EID: 0035865020     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(00)00404-8     Document Type: Article

References (50)

1. The anti-allodynic effects of amitryptiline, gabapentin and lidocaine in a rat model of neuropathic pain
2. Antagonism of baclofen-induced antinociception by intrathecal administration of phaclofen or 2-hydroxysaclofen but not d-aminovaleric acid in the rat
3. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus
4. GABAergic terminals are presynaptic to primary afferent terminals in the substantia gelatinosa of the rat spinal cord
5. B receptor site distribution in the rat central nervous system
6. Attenuation of formalin-induced nociceptive behaviours following local peripheral injection of gabapentin
7. Increase in GABAergic cells and GABA levels in the spinal cord in unilateral inflammation of the hindlimb in the rat
8. GABA decreases in the spinal cord dorsal horn after peripheral neurectomy
9. B receptor binding in the spinal cord dorsal horn following peripheral inflammation or neurectomy
10. Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats
11. GABA-B receptor-mediated spinal inhibition
12. Effects of topical baclofen on C fibre-evoked neuronal activity in the dorsal horn
13. Activity-dependent neuronal plasticity following tissue injury and inflammation
14. Gabapentin and pregabalin, but not morphine and amytriptiline, block both static and dynamic components of mechanical allodynia induced by streptozotocin in the rat
15. Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists
16. Baclofen as an adjuvant analgesic
17. Baclofen in the treatment of trigeminal neuralgia: Double-blind study and long-term follow-up
18. 2δ subunit of a calcium channel
19. Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold
20. The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain
21. The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat
22. Actions of (-)baclofen on rat dorsal horn neurons
23. Gabapentin increases GABA-induced depolarisation in rat neonatal optic nerve
24. Dorsal root potentials and afferent input to the spinal cord in rats with an experimental peripheral neuropathy
25. Anatomical distribution and ultrastructural organization of the GABAergic system in the rat spinal cord: An immunohistochemical study using anti-GABA antibodies
26. B receptor-mediated inhibition of forskolin-stimulated cyclic AMP accumulation in rat spinal cord
27. GABA and its receptors in the spinal cord
28. B antagonist, prevents antinociception and muscle relaxant effect induced by baclofen
29. Gabapentin in the management of reflex sympathetic dystrophy
30. Gabapentin suppresses ectopic discharges and reverses allodynia in neuropathic rats
31. Continuous intrathecal baclofen for severe spasticity
32. B receptors present on primary afferent terminals of the spinal cord?
33. B receptor binding sites in mammalian spinal cord
34. Gabapentin for the treatment of postherpetic neuralgia
35. GABAergic mechanism of analgesia: An update
36. On the involvement of GABA in the analgesia produced by baclofen, muscimol and morphine
37. B receptors on neurones in rat brain slices
38. A novel behavioural model of neuropathic pain disorders produced in rats by partial sciatic nerve injury
39. Spinal gabapentin is antinociceptive in the rat formalin test
40. A and glycine receptors to central sensitization: Disinhibition and touch-evoked allodynia in the spinal cord
41. Increased sensitivity to the antinociceptive activity of ± baclofen in an animal model of chronic neuropathic, but not chronic inflammatory hyperalgesia
42. Transynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: Effects of chronic constriction injury, transection, and strychnine
43. B antagonists
44. Contribution of NK1 and NK2 receptor activation to high threshold afferent fibre evoked ventral root responses in the rat spinal cord in vitro
45. Gaba-like immunoreactivity in type 1 glomueruli of rat substantia gelatinosa
46. GABA-immunoreactive neurons in the dorsal horn of the rat spinal cord
47. Gabapentin relieves abnormal pains in a rat model of painful peripheral neuropathy
48. Behavioural and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: Effect of modulatory receptor systems and excitatory amino acid antagonists
49. The effect of intrathecal gabapentin on pain behaviour and hemodynamics in the formalin test in the rat
50. Drug therapy: Spasticity