GABA(B) receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) but not neurotrophin-3 (NT-3) in brain and spinal cord of rats

Neuropharmacology

Volumn 39, Issue 3, 2000, Pages 449-462

  Heese, Klaus ^a   Otten, Uwe ^a   Mathivet, Pascal ^b   Raiteri, Maurizio ^c   Marescaux, Christian ^b   Bernasconi, Raymond ^b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b INSERM   (France)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

Brain derived neurotrophic factor; Cortex; GABA(B) receptor antagonists; Hippocampus; Nerve growth factor; Neurotrophin 3; Spinal cord

Indexed keywords

3 [1 [3 [(CYCLOHEXYLMETHYL)HYDROXYPHOSPHINYL] 2 HYDROXYPROPYLAMINO]ETHYL]BENZOIC ACID; 3 AMINOPROPYLBUTYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CGP 56433A; CGP 56999A; GLUTAMIC ACID; MESSENGER RNA; NERVE GROWTH FACTOR; NEUROTROPHIN 3; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; CONTROLLED STUDY; CONVULSION; HIPPOCAMPUS; MALE; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD;

ANIMALS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; GABA ANTAGONISTS; MALE; NERVE GROWTH FACTOR; NEUROTROPHIN 3; RATS; RATS, WISTAR; RECEPTORS, GABA-B; RNA, MESSENGER; SPINAL CORD;

EID: 0033984344     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00166-5     Document Type: Article

References (36)

1. B) receptors in cerebral cortex during the estrous cycle. Brain Research. 640:1994;33-39.
2. B) receptors in the neocortex of female rats. Brain Research. 727:1996;40-48.
3. Barbacid M. The Trk family of neurotrophin receptors. Journal of Neurobiology. 25:1994;1386-1403.
4. Barinaga M. Neurotrophic factors enter the clinic. Science. 264:1994;772-774.
5. Bengzon J., Kokaia Z., Ernfors P., Kokaia M., Leanza G., Nilsson O.G., Persson H., Lindvall O. Regulation of neurotrophin and trkA, trkB and trkC tyrosine kinase receptor messenger RNA expression in kindling. Neuroscience. 53:1993;433-446.
6. B receptors. Journal of Neural Transmission. 35(suppl.):1992;155-177.
7. B Receptors in Mammalian Function. 1990;47-60 J. Wiley and Sons, Chichester.
8. B receptor subtypes in the rat cerebral cortex. Journal of Pharmacology and Experimental Therapeutics. 262:1992;114-118.
9. B receptors. Trends in Pharmacological Sciences. 14:1993;259-261.
10. B receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord. European Journal of Pharmacology. 362:1998;143-148.
11. Bothwell M. Functional interactions of neurotrophins and neurotrophin receptors. Annual Review of Neuroscience. 18:1995;223-253.
12. B receptors. Enna S.J., Bowery N.G. The GABA Receptors. 1997;209-236 Humana Press, Totowa, NJ.
13. Bradford M.M. A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principles of protein-dye binding. Analytical Biochemistry. 72:1976;248-254.
14. Chao M. The p75 neurotrophin receptor. Journal of Neurobiology. 25:1994;1373-1385.
15. Dugich-Djordjevic M.M., Tocco G., Lapchak P.A., Pasinetti G.M., Najm I., Baudry M., Hefti F. Regionally specific and rapid increase in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid. Neuroscience. 47:1992;303-315.
16. Ernfors P., Bengzon J., Kokaia Z., Persson H., Lindvall O. Increased levels of messenger RNAs neurotrophic factors in the brain during kindling epileptogenesis. Neuron. 7:1991;165-176.
17. French S.J., Humby T., Horner C.H., Sofroniew M.V., Rattray M. Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine. Molecular Brain Research. 67:1999;124-136.
18. Gall C., Murray K., Isackson P.J. Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus. Molecular Brain Research. 9:1991;113-123.
19. B receptors are involved in the regulation of the hypothalamo-pituitary-adrenocortical (HPA) axis in male rats. Pharmacology Reviews and Communication. 8:1996;149-150.
20. Heese K., Hock C., Otten U. Inflammatory signals induce neurotrophin expression in human microglial cells. Journal of Neurochemistry. 70:1998;699-707.
21. Heese K., Otten U. Complement protein C3a induces neurotrophin expression in human microglial cells. Neural Notes. III:1998;21-23.
22. Humpel C., Wetmore C., Olson L. Regulation of brain-derived neurotrophic factor messenger RNA and protein at the cellular level in pentylenetetrazol-induced epileptic seizures. Neuroscience. 53:1993;909-918.
23. Isackson P.J. Trophic factor response to neuronal stimuli or injury. Current Opinions in Neurobiology. 5:1995;350-357.
24. Jönhagen M.E., Nordberg A., Amberla K., Bäckman L., Ebendal T., Meyerson B., Olson L., Seiger A., Shigeta M., Theodorsson E., Viitanen M., Winblad B., Wahlund L.-O. Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 9:1998;246-257.
25. Lessmann V. Neurotrophin-dependent modulation of glutamatergic synaptic transmission in the mammalian CNS. General Pharmacology. 31:1998;667-674.
26. Lewin G.R., Barde Y.-A. Physiology of the neurotrophins. Annual Review in Neuroscience. 19:1996;289-317.
27. Lindvall O., Kokaia Z., Bengzon J., Elmér E., Kokaia M. Neurotrophins and brain insults. Trends in Neuroscience. 17:1994;490-496.
28. B receptor antagonists: potential new anti-absence drugs. Journal of Neural Transmission. 35(suppl.):1992;179-188.
29. McAllister A.K., Katz L.C., Lo D.C. Neurotrophins and synaptic plasticity. Annual Review in Neuroscience. 22:1999;295-318.
30. B receptors in long-term potentiation. Experientia. 49:1993;542-546.
31. 11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (case report). Journal of Neural Transmission [P-D Sect]. 4:1992;79-95.
32. Sun F.-Y., Costa E., Mocchetti I. Adrenal steroids mediate the increase of hippocampal nerve growth factor biosynthesis following bicuculline convulsions. Neuropsychoparmacology. 8:1993;219-225.
33. B receptor antagonists on absences and convulsive seizures. European Journal of Pharmacology. 332:1997;245-255.
34. B receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors. British Journal of Pharmacology. 113:1994;1515-1521.
35. Weskamp G., Otten U. An enzyme-linked immunoassay for nerve growth factor (NGF): a tool for studying regulatory mechanisms involved in NGF production in brain and in peripheral tissue. Journal of Neurochemistry. 48:1987;1779-1786.
36. Zafra F., Castren E., Thoenen H., Lindholm D. Interplay between glutamate and γ-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons. Proceedings of the National Academy of Science, USA. 88:1991;10037-10041.