Family growth: The eukaryotic DNA polymerase revolution

Cellular and Molecular Life Sciences

Volumn 59, Issue 1, 2002, Pages 54-57

  Bebenek, K ^a   Kunkel, T A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA POLYMERASE;

CATALYSIS; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; EUKARYOTE EVOLUTION; GENE REPLICATION; GENOME; HUMAN; MISMATCH REPAIR; MITOCHONDRION; MOLECULAR BIOLOGY; MOLECULAR GENETICS; REVIEW;

ANIMALS; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI PROTEINS; EUKARYOTIC CELLS; HUMANS; MULTIGENE FAMILY; MUTAGENESIS;

EUKARYOTA;

EID: 0036164223     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-002-8405-y     Document Type: Review

References (48)

1. Eukaryotic mutagenesis and translesion replication dependent on DNA polymerase ζ and Rev1 protein
2. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7
3. Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain
4. Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro
5. Disruption of the Rev31-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality
6. Disruption of the developmentally regulated Rev31 gene causes embryonic lethality
7. DNA polymerase lambda (Pol λ), a novel eukaryotic DNA polymerase with a potential role in meiosis
8. Two novel human and mouse DNA polymerases of the polX family
9. Identification and characterization of hu- man DNA polymerase β2, a DNA polymerase β-related enzyme
10. Identification of an intrinsic 5′-deoxyribose-5-phosphate lyase activity in human DNA polymerase λ
11. DNA polymerase μ, homologous to TdT, could act as a DNA mutator in eukaryotic cells
12. DNA polymerase μ, a candidate hypermutase?
13. Double-strand breaks in DNA during somatic hypermutaion of immunoglobuline genes: Cause or consequece?
14. Pol κ: A DNA polymerase required for sister chromatid cohesion
15. Evidence that replication fork components catalyze establishment of cohesion between sister chromatids
16. The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin
17. The Y-family of DNA polymerases
18. Human DNA polymease κ: A novel DNA polymerase of unknown biological function encoded by the DINB1 gene
19. Low fidelity DNA synthesis by human DNA polymerase-η
20. Pol ι, a remarkably error-prone human DNA polymerase
21. Purification and characterization of polkappa, a DNA polymerase encoded by the human DINB1 gene
22. The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light
23. Evidence for a second function for Saccharomyces cerevisiae Rev1p
24. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Pol η
25. Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
26. Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prone replication on a template containing photoproducts
27. Ultraviolet hypermutability of a shuttle vector propagated in xeroderma pigmentosum variant cells
28. hRAD30 mutations in the variant form of xeroderma pigmentosum
29. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
30. Error rate and specificity of human and murine DNA polymerase η
31. Structure of the catalytic core of S. cerevisiae DNA polymerase η: Implications for translesion DNA synthesis
32. Proofreading of DNA polymerase η-dependent replication errors
33. Mutator effects of overproducing DNA polymerase η (Rad30) and its catalytically inactive variant in yeast
34. Somatic mutation hotspots correlate with DNA polymerase η error spectrum
35. DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
36. 5′-Deoxyribose phosphate lyase activity of human DNA polymerase ι in vitro
37. Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication
38. Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase ι
39. Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions
40. Response of human DNA polymerase ι to DNA lesions
41. Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase ι
42. The expanding polymerase universe
43. Fidelity and processivity of DNA synthesis by DNA polymerase κ, the product of the human DINB1 gene
44. Crystal structure of a Dinb lesion bypass DNA polymerase catalytic fragment reveals a classic polymerase catalytic domain
45. Crystal structure of a Y-family DNA polymerase in action: A mechanism for error-prone and lesion-bypass replication
46. Error-free and error-prone lesion bypass by human DNA polymerase κ in vitro
47. Expession of human and mouse genes encoding polκ: Testis-specific developmental regulation and AhR-dependent inducible transcription
48. Error-prone bypass of certain DNA lesions by the human DNA polymerase κ