Double-strand breaks in DNA during somatic hypermutation of Ig genes: Cause or consequence?

Trends in Immunology

Volumn 23, Issue 1, 2002, Pages 12-13

  Rogozin, Igor B ^a   Kunkel, Thomas A ^b   Pavlov, Youri I ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; DOUBLE STRANDED DNA; IMMUNOGLOBULIN J CHAIN;

DNA REPAIR; DNA STRAND BREAKAGE; IMMUNE DEFICIENCY; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; KNOCKOUT GENE; LETTER; MONTE CARLO METHOD; POINT MUTATION; SOMATIC MUTATION;

EID: 0036152170     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(01)02112-3     Document Type: Short Survey

References (14)

1. Somatic hypermutation
2. Towards an understanding of somatic hypermutation
3. Maturation of the immune response
4. Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal-center formation in mice expressing antisense RNA to DNA polymerase ζ
5. Defect in IgV gene somatic hypermutation in common variable immuno-deficiency syndrome
6. Molecular aspects of somatic hypermutation of immunoglobulin genes
7. DNA polymerases in immunity: Profiting from errors
8. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
9. Somatic mutation hotspots correlate with DNA polymerase η spectrum
10. DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
11. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation
12. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes
13. DNA breaks in hypermutating immunoglobulin genes. Evidence for a break-and-repair pathway of somatic hypermutation
14. Response 1 to 'Smaller role for pol η?'