Pharmacokinetics of ethanol: A review of the methodology

Addiction Biology

Volumn 7, Issue 1, 2002, Pages 5-14

  Matsumoto, Hiroshi ^a,b   Fukui, Yuko ^a  

^a KYOTO UNIVERSITY   (Japan)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE; 4 METHYLPYRAZOLE; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ALLYL SULFIDE; CIMETIDINE; CLOMETHIAZOLE; CYTOCHROME P450 2E1; DISULFIRAM; ISONIAZID; RANITIDINE;

ALCOHOL METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME POLYMORPHISM; FIRST PASS EFFECT; HUMAN; LIVER MICROSOME METABOLISM; PRIORITY JOURNAL; REVIEW;

ALCOHOL DEHYDROGENASE; ANIMALS; CYTOCHROME P-450 CYP2E1; ETHANOL; HUMANS; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; MODELS, THEORETICAL; RATS; SPECIES SPECIFICITY; STOMACH;

EID: 0036150848     PISSN: 13556215     EISSN: None     Source Type: Journal    
DOI: 10.1080/135562101200100553     Document Type: Review

References (107)

1. The life and work of Erik M. P. Widmark
2. Hepatic microsomal oxidzing system: In vitro characteristics and adaptive properties in vivo
3. Evidence that cytochrome P-4502E1 contributes to ethanol elimination at low doses: Effects of diallyl sulfide and 4-methyl pyrazole on ethanol elimination in the perfused rat liver
4. Cytochrome P-4502E1: Its physiological and pathological role
5. Parallel first-order and Michaelis-Menten elimination kinetics of ethanol. Respective role of alcohol dehydrogenase (ADH), non-ADH and first- order pathways
6. Estimation of ethanol first-pass effect in the perfused rat liver
7. Nomenclature of alcohol dehydrogenses
8. Role of extrahepatic alcohol dehydrogenase in rat ethanol metabolism
9. Detection of a CA repeat polymorphism in the rat class I alcohol dehydrogenase gene
10. Analysis of CA repeats in first intron of class I ADH gene in Long-Evans Cinnamon rats developing fatal intoxication after ethanol intake
11. Rabbit liver alcohol dehydrogenase: Isolation and characterization of class I isozymes
12. Structural and functional divergence of class II alcohol dehydrogenase. Cloning and characterisation of rabbit liver isoforms of the enzyme
13. Physical and enzymatic properties of a class III isozyme of human liver alcohol dehydrogenase: x-ADH
14. Inhibition of human alcohol dehydrogenases by formamides
15. New human liver alcohol dehydrogenase forms with unique kinetic characteristics
16. Characterization of three isozymes of rat alcohol dehydrogenase. Tissue distribution and physiocal and enzymatic properties
17. Metabolism of ethanol by rat pancreatic acinar cells
18. Ethanol oxidation by hepatic microsomes: Adaptive increase after ethanol feeding
19. Effects of alcohol-metabolizing enzyme inhibitors and beta-lactam antibiotics on ethanol elimination
20. Role of alcohol dehydrogenase in rat ethanol elimination kinetics
21. Induction of cytochrome P450 2E1 during chronic ethanol exposure occurs via transcription of the CYP 2E1 gene when blood alcohol concentrations are high
22. Cytochrome P450 CYP2E1 induction during alcohol exposure occurs by a two step mechanism associated with blood alcohol concentrations in rats
23. Metabolism of acetaldehyde to acetate by rat hepatic P-450s: Presence of different metabolic pathway from acetaldehyde dehydrogenase system
24. Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s
25. Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system
26. No significant expression of CYP2E1 in rat liver stellate cells
27. Expression of cytochrome P450 isoforms in rat hepatic stellate cells
28. Detection of cytochrome P4503A (CYP3A) in human hepatic stellate cells
29. Human hepatic stellate cells express class I alcohol dehydrogenase and aldehyde dehydrogenase but not cytochrome P4502E1
30. Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver
31. Cythochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis
32. Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in man
33. Phenethyl isothiocyanate, a new dietary liver aldehyde dehydrogenase inhibitor
34. Genetic polymorphism in the 5′-flanking region change transcription regulation of the human cytochrome P450IIE1 gene
35. Genetic polymorphism of cytochrome P-4502E1 related to the development of alcohol liver disease
36. Inhibition of ethanol-inducible cytochrome P450 IIE1 by 3-amino-1,2,4-triazole
37. Zonated expression of cytokines in rat liver: Effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole
38. Properties of catalase: Catalysis of coupled oxidation of alcohols
39. Catalase-dependent ethanol metabolism in vivo in deermice lacking alcohol dehydrogenase
40. Metabolism of ethanol by human brain to fatty acid ethyl ester
41. Non-oxidative ethanol metabolism by fatty acid ethyl ester
42. Molecular mechanism of ethanol metabolism by human brain to fatty acid ethyl ester
43. Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse
44. Fatty acid ethyl esters: Nonoxidative metabolites of ethanol
45. Daidzin: A potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase
46. Allosteric inhibitoin of human liver sldehyde dehydrogenase by the isoflavone prunetin
47. Daidzin suppresses ethanol consumption by Syrian golden hamsters without blocking acetaldehyde metabolism
48. Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters
49. Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: Isozyme variation and its possible role in alcohol intoxication
50. Noncompetitive-like inhibition of ethanol elimination by cyanamide treatment: Pharmacokinetic study
51. An allometric model for predicting blood ethanol elimination in mammals
52. Polymorphism of the rat liver mitochondrial aldehyde dehydrogenase cDNA
53. Mitochondrial aldehyde dehydrogenase (ALDH2) polymorphism in AA and ANA rats: Lack of genotype and phenotype line differences
54. Mitochondrial ALDH polymorphism affects ethanol-derived acetate disposition in Wistar rats
55. Rat mitochondrial aldehyde dehydrogenase polymorphism and major histocompatibility complex RT1. A phenotypes are not associated with alcohol drinking in P and NP rats
56. Voluntary alcohol drinking and acetaldehyde metabolism in F2 hybrid crosses of AA and ANA lines
57. Liver cytosolic aldehyde dehydrogenase (ALDH1) polymorphism and its inheritance in Wistar rats
58. First-pass metabolism of ethanol-a gastrointestinal barrier against the systemic toxicity of ethanol
59. High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism
60. Can the liver account for first-pass metabolism of ethanol in the rat?
61. First-pass metabolism of ethanol is negligible in rat gastric mucosa
62. Use of measurements of ethanol absorption from stomach and intestine to assess human ethanol metabolism
63. Effects of ranitidine on blood alcohol levels after ethanol ingestion. Comparison with other H2-receptor antagonists
64. Dispostion and first-pass metabolism of ethanol in humans: Is it gastric oe hepatic and does it depend on gender?
65. Postmortem diffusion of alcohol from the stomach
66. Experimental studies on postmortem diffusion of ethanol-d6 using rats
67. Antipyrine and aminopyrine induce acetaldehyde accumulation from ethanol in isolated hepatocytes
68. Inhibitory mechanism of intestinal ethanol absorption induced by high acetaldehyde concentrations: Effect of intestinal blood flow and substance specificity
69. First-pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying
70. Use of a two-compartment model to assess the pharmacokinetics of human ethanol metabolism
71. First-pass metabolism of ethanol: Gastric of hepatic, mountain or molehill
72. Influence of age, gender, and blood-alcohol concentration on the disappearance rate of alcohol from blood in drinking drivers
73. Ethanol metabolism in men and women
74. Ethanol elimination rates in mice: Effects of gender, nutrition, and chronic ethanol treatment
75. Clamping BrAC reduces experimental variance: Application to the study of acute torelance to alcohol and alcohol elimination rate
76. Gender differences in alcohol metabolism: Relationship to liver volume and effect of adjusting for body mass
77. Gender differences in blood levels, but not brain levels, of ethanol in rats
78. Binding of formamides to liver alcohol dehydrogenase
79. Influence of acid-secretion blockers on gastric and hepatic alcohol dehydrogenase in rat
80. Differential inhibition of individual human liver cytochrome P450 by cimetidine
81. Cimetidine prevents alcoholic hepatic injury in the intragastric feeding rat model
82. A new potent inhibitor of horse liver alcohol dehydrogenase: p-methylbenzyl hydroperoxide
83. Effect of phenetyl isothiocyanate on microsomal N-nitrosodimethylamine metabolism and other monooxygenase activities
84. Effects of phenyethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitroamine metabolism in rats
85. Effects of phenethyl isothiocyanate on actaminophen metabolism and hepatotoxicity in mice
86. Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans
87. Modulation of rat hepatic microsomal monoxygenase enzymes and cytotoxicity by diallyl sulfide
88. Relationship between cytochrome P450 2E1 and acetone catabolism in rats as studied with diallyl sulfide as an inhibitor
89. Increased sensitivity of the microsomal pxidation of ethanol to inhibition by pyrazole and 4-methyl pyrazole after chronic ethanol treatment
90. Oxidation of pyrazole by reconstituted systems containing cytochrome P-450 IIE1
91. Inhibitory effect of 4-methylpyrazole pn antipyrine clearance in rats
92. Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers
93. Inhibition of CYP2E1 in rat liver microsomes by dichloroethylene isomers
94. Suicide inactivation of microsomal oxidation by cis- and trans-dichloroethylene in male Fisher rats in vivo
95. Gas uptake studies of deuterium isotope effects on dichloromethane metabolism in female B6C3F1 mice in vivo
96. Do endogenous volatile organic chemicals measured in breath reflect and maintain CYP2E1 levels in vivo?
97. Pretranslational and posttranslational regulation of rat hepatic CYPs3A2 and 2E1 by dislfiram
98. Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: Hepatoprotective effects
99. Acute effects of the aldehyde dehydrogenase inhibitors, disulfiram, pargyline and cyanamide, on circulating ketone body levels in the rat
100. Effect of 4-(diethylamino)benzaldehyde on ethanol metabolism in mice
101. Identification of 4-(N,N-dipropylamino)benzaldehyde as a potent, reversible inhibitor of mouse and human class I aldehyde dehydrogenase
102. Mechanisms of inhibition of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide
103. Novel prodrugs of cyanamide that inhibit aldehyde dehydrogenase in vivo
104. Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: Importance of thiol interactions with the secondary metabolite acrolein
105. Inhibition of rat liver aldehyde dehydrogenases by acrolein
106. Mechanism for benomyl action as a mitochondrial aldehyde dehydrogenase inhibitor in mice