Metabolism of acetaldehyde to acetate by rat hepatic P-450s: Presence of different metabolic pathway from acetaldehyde dehydrogenase system

Alcoholism: Clinical and Experimental Research

Volumn 20, Issue 1 SUPPL., 1996, Pages

  Kunitoh, Satoru ^a   Asai, Hirohide ^a   Imaoka, Susumu ^a   Funae, Yoshihiko ^a   Monna, Takeyuki ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

CYP2E1; Cytochrome P 450; Microsomal Acetaldehyde Oxidation System (MAOS)

Indexed keywords

ACETALDEHYDE; ACETIC ACID; ALCOHOL; ALDEHYDE DEHYDROGENASE; CYTOCHROME P450; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOBLOTTING; IMMUNOCHEMISTRY; LIVER MICROSOME; MALE; METABOLISM; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT;

ACETALDEHYDE; ACETIC ACID; ACETIC ACIDS; ALDEHYDE OXIDOREDUCTASES; ALKANE 1-MONOOXYGENASE; ANIMALS; CHROMATOGRAPHY, ION EXCHANGE; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029875429     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1996.tb01721.x     Document Type: Article

References (25)

1. Funae Y, Imaoka S: In Shaenkman B, Greim R (eds): Handbook of Experimental Pharmacology, vol 105. Heidelberg, Springer, 1993, pp 221-238
2. Koop DR, Nordblom GD, Coon MJ: Immunochemical evidence for a role cytochrome P450 in liver microsomal ethanol oxidation. Arch Biochem Biophys 235:228-238, 1984
3. Lieber CS: Mechanism of ethanol induced hepatic injury. Pharmacol Ther 46:1-41, 1990
4. Ingelman-Sandberg M, Johansson I, Yin H, Terelius EE, Albano E: Ethanol-inducible cytochrome P4502E1 genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease. Alcohol 10:447-452, 1993
5. Kunitoh S, Tanaka T, Imaoka S, Funae Y, Monna T: Contribution of cytochrome P450s and MEOS (microsomal ethanol-oxidizing system): A specific and sensitive assay of MEOS activity by HPLC with fluorescence labeling. Alcohol Alcohol 28 S1B:63-68, 1993
6. Lieber CS, DeCarli LM: Hepatic microsomal ethanol oxidizing system. J Biol Chem 254:2505-2512, 1970
7. Peters TJ, Ward RJ: Role of acetaldehyde in the pathogenesis of alcoholic liver disease. Mol Aspects Med 10:179-190, 1988
8. Koivula T, Koivusalo M: Different froms of rat liver aldehyde dehydrogenase and their subcellular distribution. Biochim Biophys Acta 397:9-23, 1975
9. Tottmar SOC, Peterson H, Kiessling KH: The subcellular distribution and properties of aldehyde dehydrogenase in rat liver. Biochem J 135:577-586, 1973
10. Tsutsumi M, Takada A, Takase S: The intralobular distribution of aldehyde dehydrogenase isozyme: Differences with respect to species. Alcohol 5:33-38, 1988
11. Watanabe K, Narimatsu S, Yamamoto I, Yoshimura H: Oxygenation mechanism in conversion of aldehyde to carboxylic acid catalyzed by a cytochrome P450 isozyme. J Biol Chem 266:2709-2711, 1991
12. Telelius Y, Norsten-Hoog C, Cronholm T, Ingelman-Sandberg M: Acetaldehyde as a substrate for ethanol-induced cytochrome P450 (CYP2E1). Biochem Biophys Res Commun 79:689-694, 1991
13. DeCarli LM, Lieber CS: Fatty liver in the rats after prolonged intake of ethanol with a nutritionally adequate new liquid diet. J Nutr 91:331-338, 1967
14. Funae Y, Imaoka S: Simultaneous purification of multiple forms of rat liver microsomal cytochrome P450 by high-performance liquid chromatography. Biochim Biophys Acta 842:119-132, 1985
15. Funae Y, Imaoka S: Purification and characterization of liver microsomal cytochrome P450 from untreated male rats. Biochim Biophys Acta 926:349-358, 1987
16. Yasukochi Y, Masters BSS: Some properties detergent-solubilized NADPH-cytochrome C reductase purified by biospecific affinity chromatography. J Biol Chem 251:5337-5342, 1976
17. Von Korff R: Ion-exchange chromatography of citric acid cycle components and related compounds. Method Enzymol 13:425-430, 1969
18. Wickramasinghe SN: Observations on the biochemical basis of ethanol metabolism by human macrophages. Alcohol Alcoholism 21:57-63, 1986
19. Imaoka S, Terano Y, Funae Y: Purification and characterization of two constitutive cytochrome P450 (F-1 and F-2) from adult female rats: Identification of P450 F-1 as the phenobarbital-inducible cytochrome P450 in male rat liver. Biochim Biophys Acta 916:358-367, 1987
20. Imaoka S, Terano Y, Funae Y: Expression of four phenobarbital-inducible cytochrome P450s in liver, kidney and lung of rats. J Biochem 105:939-945, 1989
21. Omura T, Sato R: The carbon monooxide binding pigment of liver: Evidence for its hemoprotein nature, solubilization, purification and properties. J Biol Chem 239:2370-2379, 1964
22. Lowry OH, Rosebrough NJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-272, 1951
23. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
24. Harada S, Agarwal DP, Goedde HW: Aldehyde dehydrogenase deficiency as a cause of facial flushing reaction to alcohol in Japanese. Lancet 2:982, 1981
25. Weiner H: Subcellular localization of acetaldehyde oxidation on liver. Ann NY Acad Sci 492:25-34, 1987