Pretranslational and posttranslational regulation of rat hepatic CYPs 3A2 and 2E1 by disulfiram

Biochemical Pharmacology

Volumn 54, Issue 12, 1997, Pages 1323-1329

  Martini, Robert ^a   Ingelman Sundberg, Magnus ^b   Murray, Michael ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cytochrome P450; Disulfiram; Gene regulation; Mechanism based inactivation; Pharmacokinetic interactions

Indexed keywords

ALDEHYDE DEHYDROGENASE INHIBITOR; CYTOCHROME P450; DISULFIRAM; ISOENZYME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INTERACTION; ENZYME INHIBITION; GENE CONTROL; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RAT;

ALCOHOL DETERRENTS; ANIMALS; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; DISULFIRAM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MICROSOMES, LIVER; OXIDATION-REDUCTION; PROTEIN BIOSYNTHESIS; RATS; RATS, WISTAR; RNA, MESSENGER; STEROID HYDROXYLASES;

EID: 0030670952     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00360-2     Document Type: Article

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