Oncogenic β-catenin and MMP-7 (matrilysin) cosegregate in late-stage clinical colon cancer

Gastroenterology

Volumn 122, Issue 1, 2002, Pages 60-71

  Ougolkov, Andrei V ^a   Minamoto, Toshinari ^a   Yamashita, Kaname ^a   Mai, Masayoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; MATRILYSIN;

ADULT; AGED; ARTICLE; BIOACCUMULATION; CANCER INVASION; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CELL NUCLEUS; COLON CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRACELLULAR TRANSPORT; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; ONCOGENE; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; TRANSACTIVATION;

EID: 0036142231     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.30306     Document Type: Article

References (77)

1. A genetic model for colorectal tumorigenesis
2. Lessons from hereditary colorectal cancer
3. ras oncogenes in human cancer: A review
4. Mutations of ras genes in human tumors
5. Small GTP-binding proteins of the ras family: A conserved functional mechanism?
6. The many roads that lead to ras
7. Ras oncogene detection in pre-neoplastic lesions: Possible applications for diagnosis and prevention
8. K-ras mutation: Early detection in molecular diagnosis and risk assessment of colorectal, pancreas and lung cancers
9. β-catenin: A key mediator of Wnt signaling
10. The oncogenic activation of beta-catenin
11. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species
12. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryo
13. Functional interaction of β-catenin with the transcription factor LEF-1
14. Nuclear localization of β-catenin by interaction with transcription factor LEF-1
15. 2+ pathways
16. -/- colon carcinoma
17. Identification of c-MYC as a target of the APC pathway
18. β-catenin regulates expression of cyclin D1 in colon carcinoma cells
19. Target genes of beta-catenin-T-cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas
20. The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors
21. β-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
22. Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma
23. Messenger RNA for two type IV collagenases is located in stromal cells in human colon cancer
24. Neoplastic progression of human colorectal cancer is associated with overexpression of the stromelysin-3 and BM-40/SPARC genes
25. Distinct pattern of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 mRNA expression in human colorectal cancer and liver metastases
26. Matrix metalloprotease 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) type IV collagenases in colorectal cancer
27. Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis
28. Overexpression of matrix metalloproteinase-7 mRNA in human colon carcinomas
29. Matrilysin is associated with progression of colorectal tumor
30. Enhanced secretion and activation of matrilysin during malignant conversion of human colorectal epithelium and its relationship with invasive potential of colon cancer cells
31. Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers
32. Expression of MMP-7 (PUMP-1) mRNA in human colorectal cancers
33. β-catenin expression in primary and metastasic colorectal carcinoma
34. A one-step sandwich-enzyme immunoassay for human matrix metalloproteinase 7 (matrilysin) using monoclonal antibodies
35. Expression and tissue localization of matrix metalloproteinase 7 (matrilysin) in human gastric carcinomas. Implications for vessel invasion and metastasis
36. Rapid detection of ras oncogenes in human tumors: Application to colon, esophageal, and gastric cancer
37. Detection of Ki-ras mutation in non-neoplastic mucosa of Japanese patients with colorectal cancers
38. Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas
39. Activation of K-ras 2 gene in human colon and lung carcinomas by two different point mutations
40. Predictive value of nuclear beta-catenin expression for the occurrence of distant metastases in rectal cancer
41. Nuclear overexpression of the oncoprotein β-catenin in colorectal cancer is localized predominantly at the invasion front
42. Tumor and stromal expression matrix metalloproteinases and their role in tumor progression
43. Structure and expression of the human gene for the matrix metalloproteinase matrilysin
44. Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer
45. APC mutations are sufficient for the growth of early colorectal adenomas
46. Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas
47. Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations
48. The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis
49. Wnt/β-catenin signaling induces the expression and activity of βTrCP ubiquitin ligase receptor
50. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability
51. Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription
52. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
53. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis
54. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways
55. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
56. Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
57. Abrogation of the presenilin 1/β-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation
58. Presenilin 1 facilitates the constitutive turnover of β-catenin: Differential activity of Alzheimer's disease-linked PS1 mutations in the β-catenin-signaling pathway
59. Interaction between Wnt and TGF-β signaling pathways during formation of Spemann's organizer
60. Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-β and Wnt pathways
61. The TAK1-NLK-MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
62. Cross-regulation of the Wnt signalling pathway: A role of MAP kinases
63. TGF-beta signalling from cell membrane to nucleus through SMAD proteins
64. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
65. Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers
66. MADR2 maps to 18q21 and encodes a TGF-beta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
67. Somatic alterations of the DPC4 gene in human colorectal cancers in vivo
68. Transforming growth factor β stimulation of colorectal cancer cell lines: Type II receptor bypass and changes in adhesion molecule expression
69. Ras signalling and apoptosis
70. The Akt proto-oncogene links Ras to Pak and cell survival signals
71. 1 cell cycle progression
72. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
73. K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression
74. Excess β-catenin promotes accumulation of transcriptionally active p53
75. Regulation of Lef-mediated transcription and p53-dependent pathway by associating β-catenin with CBP/p300