Predictive value of nuclear betacatenin expression for the occurrence of distant metastases in rectal cancer

Diseases of the Colon and Rectum

Volumn 41, Issue 10, 1998, Pages 1256-1261

  Günther, Klaus ^a,b   Brabletz, T ^a   Kraus, C ^a   Dworak, O ^a   Reymond, M A ^a   Jung, A ^a   Hohenberger, W ^a   Kirchner, T ^a   Kockerling F ^a   Ballhausen, W G ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Beta catenin; Immunohistochemistry; Metastasis; Predictive value; Prognosis; Rectal cancer; Tumor marker

Indexed keywords

BETA CATENIN; TUMOR MARKER;

ADULT; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; METASTASIS; METASTASIS POTENTIAL; PREDICTION; PROGNOSIS; PROTEIN EXPRESSION; RECTUM CANCER;

ADENOCARCINOMA; BETA CATENIN; CADHERINS; CYTOSKELETAL PROTEINS; DISEASE-FREE SURVIVAL; DNA, NEOPLASM; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RECTAL NEOPLASMS; SEQUENCE ANALYSIS, DNA; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL;

EID: 7844229105     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02258226     Document Type: Article

References (13)

1. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-70.
2. Korinek V, Barker N, Morin PJ, et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC -/- colon carcinoma. Science 1997;275: 1784-7.
3. Morin PJ, Sparks AB, Korinek V, et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997;275:1787-90.
4. Peifer M. beta-catenin as oncogene: the smoking gun. Science 1997;275:1752-3.
5. Inomata M, Ochiai A, Akimoto S, Kitano S, Hirohashi S. Alteration of beta-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients. Cancer Res 1996;56:2213-7.
6. Köckerling F, Reymond MA, Altendorf-Hofmann A, Hohenberger W. The influence of surgery on metachronous distant metastases and survival in rectal cancer. J Clin Oncol 1998;16:1-7.
7. UICC. TNM Klassifikation maligner Tumoren. 4th ed. Berlin: Springer-Verlag, 1987.
8. Ilyas M, Tomlinson IPM, Rowan A, Pignatelli M, Bodmer WF. Beta-catenin mutations in cell lines established from human colorectal cancers. Proc Natl Acad Sci U S A 1997;94:10330-4.
9. Smith KJ, Johnson KA, Bryan TM, et al. The APC gene product in normal and tumor cells. Proc Natl Acad Sci U S A 1993;90:2846-50.
10. Mayer K, Wolff E, Clevers H, Ballhausen WG. The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA. Biochim Biophys Acta 1995;1263:169-72.
11. Mayer K, Hieronymus T, Castrop J, Clevers H. Ballhausen WG. Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells. Int J Cancer 1997;72: 625-30.
12. Hayes DF, Bast RC, Desch CE, et al. Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers. J Natl Cancer Inst 1996;88:1456-66.
13. cas) in bladder tumors. Cancer Res 1996;56:4154-8.