Inhibition of telomerase activity in endometrial cancer cells by selenium-cisplatin conjugate despite suppression of its DNA-damaging activity by sodium ascorbate

Teratogenesis Carcinogenesis and Mutagenesis

Volumn 22, Issue 1, 2002, Pages 73-82

  Basiak, Janusz ^a   Kadubek, Magdalena ^a   Kowalik, Joanna ^a   Romanowicz Makowska, Hanna ^b   Pertyski, Tomasz ^b  

^a UNIVERSITY OF LODZ   (Poland)

^b POLISH MOTHER S MEMORIAL HOSPITAL RESEARCH INSTITUTE   (Poland)

Author keywords

Comet assay; Genotoxic effects of anticancer drugs; Se Pt conjugate (NH3)2Pt(SeO3) ; Telomere repeat amplification protocol (TRAP); Vitamin C

Indexed keywords

ASCORBIC ACID; CISPLATIN; DNA; RNA; SELENIUM;

ARTICLE; CELL IMMORTALIZATION; CELL TRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG ACTIVITY; DRUG CONJUGATION; ENDOMETRIUM CANCER; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; FEMALE; GEL ELECTROPHORESIS; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; SOMATIC CELL; TANDEM REPEAT; TELOMERE; TELOMERE REPEAT AMPLIFICATION PROTOCOL ASSAY;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; ASCORBIC ACID; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CISPLATIN; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; POLYMERASE CHAIN REACTION; SELENIUM COMPOUNDS; TELOMERASE; TELOMERE;

EID: 0036136645     PISSN: 02703211     EISSN: None     Source Type: Journal    
DOI: 10.1002/tcm.1040     Document Type: Article

References (37)

1. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
2. Telomere length regulation
3. Functional requirement of p23 and Hsp90 in telomerase complexes
4. Identification of two RNA-binding proteins associated with human telomerase RNA
5. A telomerase component is defective in the human disease dyskeratosis congenital
6. Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo
7. Telomeres, telomerase and cancer: An up-date
8. Telomerase and early detection of cancer: A National Cancer Institute Workshop
9. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
10. Expression profile of the putative catalytic subunit of the telomerase gene
11. Correlating telomerase activity levels with human neuroblastoma outcomes
12. Telomerase activity and survival of patients with node-positive breast cancer
13. Recent advances in the development of telomerase inhibitors for the treatment of cancer
14. The RNA component of human telomerase
15. Inhibition of telomerase activity of melanoma cells in vitro by antisense oligonucleotides
16. Inhibition of human telomerase activity by peptide nucleic acids
17. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines
18. Telomerase from human leukemia cells: Properties and its interaction with deoxynucleotide analogues
19. Irreversible telomere shortening by 3′-azido-2′,3′-dideoxythymidine (AZT) treatment
20. Inhibition of telomerase by G-quartet DANN structures
21. Inhibition of human telomerase by a G-quadruplex-interactive compound
22. Telomerase assay as a possible predictor of the response to anticancer chemotherapy
23. Inhibition of telomerase activity by cisplatin in human testicular cancer cells
24. Effects of tamoxifen on telomerase activity in breast carcinoma cell lines
25. Suppresion of telomerase activity as an indicator of drug-induced cytotoxicity against cancer cells: In vitro studies with fresh human tumor samples
26. DNA damage and repair in human lymphocytes exposed to three anticancer platinum drugs
27. Protective action of vitamin C against DNA damage induced by seleniumcispaltin conjugate
28. A simple technique for quantification of low levels of DNA damage in individual cells
29. Direct enzymatic detection of endogenous base damage in human lymphocyte DNA
30. The comet assay: Mechanisms and technical considerations
31. A comparison of the in vitro genotoxicity of tri- and hexavalent chromium
32. The single cell gel electrophoresis assay for induced DNA damage (comet assay): Measurement of tail length and moment
33. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
34. Telomerase activity as a possible predictor for the response to anticancer chemotherapy
35. Absence of telomerase activity and telomerase catalytic subunit mRNA in melanocyte cultures
36. Analysis of telomerase expression and proliferative activity in the different layers of cyclic endometrium
37. Specific association of human telomerase activity with immortal cell and cancer