Development and use of multimeric major histocompatibility complex molecules

Clinical and Diagnostic Laboratory Immunology

Volumn 9, Issue 2, 2002, Pages 216-220

  Greten, Tim F ^a   Schneck, Jonathan P ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA ANTIGEN; IMMUNOGLOBULIN G ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; TETRAMER;

ANALYTIC METHOD; BINDING AFFINITY; CELL CLONING; CELL SELECTION; CELL SPECIFICITY; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; HUMORAL IMMUNITY; IMMUNOTHERAPY; INFLUENZA; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; SHORT SURVEY; T LYMPHOCYTE;

HUMANS; IMMUNOENZYME TECHNIQUES; MAJOR HISTOCOMPATIBILITY COMPLEX; T-LYMPHOCYTES;

EID: 0036127888     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/CDLI.9.2.216-220.2002     Document Type: Short Survey

References (57)

1. Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells
2. Phenotypic analysis of antigen-specific T lymphocytes
3. An expanded peripheral T cell population to a cytotoxic T lymphocyte (CTL)-defined, melanocyte-specific antigen in metastatic melanoma patients impacts on generation of peptide-specific CTLs but does not overcome tumor escape from immune surveillance in metastatic lesions
4. High frequency of autologous anti-melanoma CTL directed against an antigen generated by a point mutation in a new helicase gene
5. New methods for assessing T-cell responses
6. + lymphocyte clones: Effect of natural polymorphism on T cell recognition and endogenous cognate antigen presentation by liver cells
7. HLA-E binds to natural killer cell receptors CD94/NKG2A
8. + T cells based on cytokine secretion
9. T cell affinity maturation by selective expansion during infection
10. + T cells during experimental virus infection
11. T cell receptor-MHC class I peptide interactions: Affinity, kinetics, and specificity
12. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes
13. A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations
14. Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells
15. Direct measurement of CD8+ T cell responses in macaques infected with simian immunodeficiency virus
16. + T cells
17. Cutting edge: Rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma
18. Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood
19. Quantitative studies on T cell diversity. I. Determination of the precursor frequencies for two types of streptococcus A-specific helper cells in nonimmune, polyclonally activated splenic T cells
20. + T lymphocytes using MHC tetramers in kidney transplant patients and healthy participants
21. Increased TCR avidity after T cell activation: A mechanism for sensing low-density antigen
22. + T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients
23. In situ detection of virus- and tumor-specific T-cell immunity
24. Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: The role of CD4 coreceptor
25. + T cells in peripheral blood and liver using peptide-MHC tetramers
26. + cancers
27. Monitoring CD8 T cell responses to NY-ESO-1: Correlation of humoral and cellular immune responses
28. Interleukin-18 gene transfer increases antitumor effects of suicide gene therapy through efficient induction of antitumor immunity
29. Detection of intracellular cytokines by flow cytometry
30. Expression of recombinant HLA-DR2 molecules. Replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR alpha beta heterodimers
31. T-cell epitope mapping by flow cytometry
32. Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex
33. HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: Direct detection of immunodominant antigen-responsive cells
34. + memory T cells
35. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients
36. Determination of lymphocyte division by flow cytometry
37. Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1
38. TCR avidity: It's not how strong you make it, it's how you make it strong
39. Low affinity interaction of peptide-MHC complexes with T cell receptors
40. Direct enumeration of borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers
41. Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specfic cytotoxic T lymphocytes in patients with graft-versus-host disease
42. Simian immunodeficiency virus-specific cytotoxic T lymphocytes and protection against challenge in rhesus macaques immunized with a live attenuated simian immunodeficiency virus vaccine
43. + T cells proliferating in response to influenza A antigen
44. + T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals
45. A kinetic basis for T cell receptor repertoire selection during an immune response
46. Attrition of T cell memory: Selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
47. + cycotoxic T-lymphocytes in liver transplant patients
48. Cutting edge: In situ tetramer staining of antigen-specific T cells in tissues
49. Enhanced antigen-specific antitumor immunity with altered peptide ligands that stabilize the MHC-peptide-TCR complex
50. + CTL specific for the mycobacterial major secreted antigen 85A
51. Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes
52. Assessing CD8 T cell number and dysfunction in the presence of antigen
53. Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent
54. Monitoring of antigen-specific cytolytic T lymphocytes in cancer patients receiving immunotherapy
55. + T cells with a defect in effector function that is reversible on extended interleukin-2 incubation
56. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers
57. Viral immune evasion due to persistence of activated T cells without effector function