Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F

Molecular and Cellular Biology

Volumn 16, Issue 4, 1996, Pages 1659-1667

  Karlseder, Jan ^a   Rotheneder, Hans ^a   Wintersberger, Erhard ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

EID: 0029926303     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.4.1659     Document Type: Article

References (75)

1. Adams, C. C., and J. L. Workman. 1995. Binding of disparate transcriptional activators to nucleosomal DNA is inherently cooperative. Mol. Cell. Biol. 15:1405-1421.
2. Aubin, R. J., M. Weinfeld, and M. C. Paterson. 1988. Factors influencing efficiency and reproducibility of polybrene-assisted gene transfer. Somatic Cell Mol Genet. 14:155-167.
3. Bandara, L. R., V. M. Buck, M. Zamanian, L. H. Johnston, and N. B. La Thangue. 1993. Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F EMBO J. 12:4317-4324
4. Bandara, L. R., E. W.-F. Lam, T.-S. Sorensen, M. Zamanlan, R. Girling, and N. B. La Thangue. 1994. DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. EMBO J 13:3104-3114.
5. Beijersbergen, R. L., R. M. Kerkhoven, L. Zhu, L. Carlee, P. M. Voorhoeve, and R. Bernards. 1994. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with 107 in vivo. Genes Dev. 8:2680-2690.
6. Blake, M. C., and J. C. Azizkhan. 1989. Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo. Mol. Cell. Biol 9:4994-5002.
7. Blake, M. C., R. C. Jambou, A. G. Swick, J. W. Kahn, and J. C. Azizkhan. 1990 Transcriptional initiation is controlled by upstream GC-box interactions in a TATA-less promoter. Mol. Cell. Biol. 10:6632-6641.
8. Dou, Q.-P., S. Zhao, A. H. Levin, J. Wang, K. Helin, and A. B. Pardee. 1994 G1/S-regulated E2F-containing promoter complexes bind to the mouse thymidine kinase gene promoter. J. Biol. Chem. 269:1306-1313.
9. Dyson, N., M. Dembski, A. Fattaey, C. Ngwu, M. Ewen, and K. Helin. 1993. Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1 J Virol. 67:7641-7647.
10. Fetzer, J., M. Michael, T. Bohnert, R. Hofbauer, and G. Folkers. 1994. A new and fast method for highly pure recombinant herpes simplex virus type 1 thymidine kinase. Protein Expr. Purif. 5:432-441.
11. Fridovich-Keil, J. L., P. J. Markell, J. M. Gudas, and A. B. Pardee. 1993. DNA sequences required for serum-responsive regulation of expression from the mouse thymidine kinase promoter. Cell Growth Differ. 4:679-687
12. Ginsberg, D., G. Vairo, T. Chittenden, Z.-X. Xiao, G. Xu, K. L. Wydner, J. A. DeCaprio, J. B. Lawrence, and D. M. Livingston. 1994 E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 8:2665-2679.
13. Girling, R., J. F. Partridge, L. R. Bandara, N. Burden, N. F. Totty, J. J. Hsuan, and N. B. La Thangue. 1993. A new component of the transcription factor DRTF1/E2F. Nature (London) 362:83-87.
14. Gorman, C. H. 1985. High-efficiency gene transfer into mammalian cells. p. 143-190. In D. M. Glover (ed.), DNA cloning a practical approach, vol II. IRL Press, Oxford.
15. Gudas, J. M., J. L. Fridovich-Keil, M. W. Datta, J. Bryan, and A. B. Pardee. 1992. Characterization of the murine thymidine kinase-encoding gene and analysis of transcription start point heterogeneity. Gene 118:205-216.
16. Hagemeier, C., A. Cook, and T. Kouzarides. 1993. The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro. Nucleic Acids Res. 21:4998-5004.
17. Hamel, P. A., B. L. Gallie, and R. A. Phillips. 1992. The retinoblastoma protein and cell cycle regulation. Trends Genet. 8:180-185.
18. Helin, K., J. A. Lees, M. Vidal, N. Dyson, E. Hallow, and A. Fattaey. 1992. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70:337-350.
19. Helin, K., C.-L. Wu, A. R. Fattaey, J. A. Lees, B. D. Dynlacht, C. Ngwu, and E. Harlow. 1993. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 7:1850-1861.
20. Hiebert, S. W., M. Blake, J. Azizkhan, and J. R. Nevins. 1991. Role of E2F transcription factor in E1A-mediated trans activation of cellular genes J. Virol. 65:3547-3552.
21. Hiebert, S. W., S. P. Chellappan, J. M. Horowitz, and J. R. Nevins. 1992. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev. 6:177-185.
22. Hijmans, E. M., P. M. Voorhoeve, R. L. Beijersbergen, L. J. van't Veer, and R. Bernards. 1995. E2F-5, a new E2F family member that interacts with p130 in vivo. Mol. Cell. Diol. 15:3082-3089.
23. Hoey, T., R. O. J. Weinzierl, G. Gill, J.-L. Chen, B. D. Dynlacht, and R. Tjian. 1993 Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell 72:247-260.
24. Huber, H. E., G. Edwards, P. J. Goodhart, D. R. Patrick, P. S. Huang, M. Ivey-Hoyle, S. F. Barnett, A. Oliff, and D, C. Heimbrook. 1993. Transcription factor E2F binds DNA as a heterodimer. Proc. Natl. Acad. Sci. USA 90: 3525-3529.
25. Imataka, H., K. Sogawa, K. Yasumoto, Y. Kikuchi, K. Sasano, A. Kobayashi, M. Hayami, and Y. Fujii-Kuriyama. 1992. Two regulatory proteins that bind to the basic transcription element (BTE), a GC bos sequence in the promoter region of the rat P-4501A1 gene. EMBO J. 11:3663-3671.
26. Ivey-Hoyle, M., R. Conroy, H. E. Huber, P. J. Goodhart, A. Oliff, and D. C. Heimbrook. 1993. Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol. Cell. Biol. 13:7802-7812.
27. Janson, L., and U. Pettersson. 1990. Cooperative interaction between transcription factor Sp1 and OTF-1. Proc. Natl. Acad. Sci. USA 87:4732-4736.
28. Jordan, K. L., A. R. Haas, T. J. Logan, and D. J. Hall. 1994. Detailed analysis of the basic domain of the E2F1 transcription factor indicates that it is unique among bHLH proteins. Oncogene 9:1177-1185.
29. Kadonaga, J. T., K. R. Carner, P. A. Luciw, and R. Tjian. 1987. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA-binding domain. Cell 51:1079-1090.
30. Kaelin, W. G., Jr., W. Krek, W. R. Sellers, J. A. DeCaprio, F. Ajchenbaum, C. S. Fuchs, T. Chittenden, Y. Li, P. J. Farnham, M. A. Blanar, D. M. Livingston, and E. K. Flemington. 1992. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70:351-364.
31. Kaelin, W. G., Jr., D. C. Pallas, J. A. DeCaprio, F. J. Kaye, and D. M. Livingston. 1991. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell 64:521-532.
32. Kitagawa, M., H. Higashi, I. Suzuki-Takahashi, K. Segawa, S. K. Hanks, Y. Taya, S. Nishimura, and A. Okuyama. 1995. Phosphorylation of E2F-1 by cyclin A-cdk2. Oncogene 10:229-236.
33. Kouzarides, T. 1993. Transcriptional regulation by the retinoblastoma protein Trends Cell Biol. 3:211-213.
34. Krek, W., M. E. Ewen, S. Shirodkar, Z. Arany, W. G. Kaelin, Jr., and D. M. Livingston. 1994. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78:161-172
35. Lai, J.-S., and W. Herr. 1992. Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations. Proc. Natl. Acad. Sci. USA 89:6958-6962.
36. Lam, E. W.-F., and N. B. La Thangue. 1994. DP and E2F proteins: coordinating transcription with cell cycle progression. Curr. Opin. Cell Biol 6:859-866.
37. La Thangue, N. B. 1994. DTRF/E2F: and expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci 19:108-114
38. Lees, J. E., M. Saito, M. Vidal, M. Valentine, T. Look, E. Harlow, N. Dyson, and K. Helin. 1993. The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell. Biol. 13:7813-7825.
39. Li, R., J. D. Knight, S. P. Jackson, R. Tjian, and M. R. Botchan. 1991. Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell 65:493-505
40. Li, Y., J. E. Slansky, D. J. Myers, N. R. Drinkwater, W. G. Kaelin, Jr., and P. J. Farnham. 1994. Cloning, chromosomal location and characterization of mouse E2F1. Mol. Cell Biol. 14:1861-1869.
41. Lieberman, H. B., P.-F. Lin, D.-B. Yeh, and F. H. Ruddle. 1988. Transcriptional and posttranscriptional mechanisms regulate murine thymidine kinase gene expression in serum-stimulated cells. Mol. Cell. Biol. 8:5280-5291.
42. Lin, S.-Y., A. R. Black, D. Kostic, S. Pajovic, C. N. Hoover, and J. C. Azizkhan. 1996 Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol. Cell. Biol. 16:1668-1675.
43. Merika, M., and S. Orkin. 1995. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Kruppel family proteins Sp1 and EKLF Mol. Cell. Biol. 15:2437-2447
44. Moran, E. 1993. DNA tumor virus transforming proteins and the cell cycle. Curr. Opin. Genet. Dev. 3:63-70.
45. Mueller, P. R., S. J. Salser, and B. Wold. 1988. Constitutive and metal-inducible protein.DNA interactions at the mouse metallothionein I promoter examined by in vivo and in vitro footprinting Genes Dev. 2:412-427.
46. Mueller, P. R., and B. Wold. 1989. In vivo footprinting of a muscle specific enhancer by ligation mediated PCR. Science 246:780-286.
47. Murata, Y., H. G. Kim, K. T. Rogers, A. J. Udvadia, and J. M. Horowitz. 1994. Negative regulation of Sp1 trans-activation is correlated with the binding of cellular proteins to the ammo terminus of the Sp1 trans-activation domain J. Biol. Chem. 269:20674-20681.
48. Naeve, G. S., A. Sharma, and A. S. Lee. 1991. Temporal events regulating the early phases of the mammalian cell cycle. Curr. Biol. 3:261-268
49. Nevins, J. R. 1992. H2F: a Link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
50. Nevins, J. R. 1994. Cell cycle targets of the DNA tumor viruses. Curr. Opin. Genet. Dev. 4:130-134.
51. Ogris, E., H. Rotheneder, I. Mudrak, A. Pichler, and E. Wintersberger. 1993. A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene. J. Virol. 67:1765-1771.
52. Pagano, M., G. Draetta, and P. Jansen-Dürr. 1992 Association of cdk2 kinase with the transcription factor E2F during S phase Science 255:1144-1147.
53. Pardee, A. B. 1989. G1 events and regulation of cell proliferation. Science 255:603-608.
54. Pascal, E., and R. Tjian. 1991. Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism. Genes Dev. 5:1646-1656.
55. Plet, A., N. Tourkine, N. Mechti, P. Janteur, and J. M. Blanchard. 1992 In vivo footprints between the murine c-myc P1 and P2 promoters Oncogene 7:1847-1851.
56. Pugh, B. F., and R. Tjian. 1990. Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell 61:1187-1197.
57. Pugh, B. F., and R. Tjian. 1991. Transcription from a TATA-less promoter requires a multisubunit TFIID complex. Genes Dev. 5:1935-1945.
58. Rotheneder, H., M. Grabner, and E. Wintersberger. 1991. Presence of regulatory sequences within intron 2 of the mouse thymidine kinase gene. Nucleic Acids Res. 19:6805-6809.
59. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
60. Sardet, C., M. Vidal, D. Cobrinik, Y. Geng, C. Onufryk, A. Chen, and R. A. Weinberg. 1995. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc. Natl. Acad. Sci. USA 92:2403-2407.
61. Seiser, C., M. Knöfler, I. Rudelstorfer, R. Haas, and E. Wintersberger. 1989. Mouse thymidine kinase: the promoter sequence and the gene and pseudogene structures in normal cells and in thymidine kinase deficient mutants. Nucleic Acids Res. 17:185-195.
62. Seto, E., B. Lewis, and T. Shenk. 1993. Interaction between transcription factors Sp1 and YY1. Nature (London) 365:462-464.
63. Shan, B., X. Zhu, P.-L. Chen, T. Durfee, Y. Yang, D. Sharp, and W. H. Lee. 1992. Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol 12:5620-5631.
64. Sherr, C. J. 1994. The ins and outs of RB: coupling gene expression to the cell cycle clock Trends Cell Biol. 4:15-18.
65. Slansky, J. E., Y. Li, W. G. Kaelin, Jr., and P. J. Farnham. 1993. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol. Cell. Biol. 13:1610-1618.
66. Vairo, G., D. M. Livingston, and D. Ginsberg. 1995. Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev. 9:869-881.
67. Wade, M., M. C. Blake, R. C. Jambon, K. Helin, E. Harlow, and J. C. Azizkhan. 1995. An inverted repeat motif stabilizes binding of E2F and enhances transcription of the dihydrofolate reductase gene. J. Biol. Chem. 270:9783-9891.
68. Weichselbraun, I., E. Ogris, and E. Wintersberger. 1990. Bidirectional promoter activity of the 5′ flanking region of the mouse thymidine kinase gene. FEBS Lett 275:49-52.
69. Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
70. Weinzierl, R. O. J., B. D. Dynlacht, and R. Tjian. 1993. Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator. Nature (London) 362:511-517.
71. Wintersberger, E. 1991 Biochemical events controlling initiation and propagation of the S phase of the cell cycle. Rev. Physiol. Biochem. Pharmacol. 118:49-95.
72. Wintersberger, E., H. Rotheneder, M. Grabner, G. Beck, and C. Seiser. 1992 Regulation of thymidine kinase during growth, cell cycle and differentiation. Adv. Enzyme Regul. 32:241-254.
73. Wu, C.-L., L. R. Zukerberg, C. Ngwu, E. Harlow, and J. E. Lees. 1995. In vivo association of E2F and DP family proteins. Mol Cell. Biol. 15:2536-2546.
74. Xu, M., K.-A. Sheppard, C.-Y. Peng, A. S. Yee, and H. Piwnica-Worms. 1994. Cyclin A/cdks binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol. Cell. Biol 14:8420-8431.
75. Zhang, Y., and S. P. Chellappan. 1995. Cloning and characterization of human DP2, a novel dimerization partner of E2F. Oncogene 10:2085-2093.