Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma

Diabetes Research and Clinical Practice

Volumn 56, Issue 2, 2002, Pages 83-92

  Kawai, Toshihide ^a   Hirose, Hiroshi ^a   Seto, Yoshiko ^a   Fujita, Haruhisa ^a   Fujita, Hiroshi ^a   Ukeda, Kaname ^a   Saruta, Takao ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

ATP sensitive K+ channel; INS 1 cell; Lipotoxicity; PPAR gamma; Troglitazone

Indexed keywords

ADENOSINE TRIPHOSPHATE; DIAZOXIDE; FATTY ACID; GLUCOSE; INSULIN; LINOLEIC ACID; OLEIC ACID; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; TROGLITAZONE;

ANIMAL CELL; CELL LINE; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; INCUBATION TIME; INSULIN RELEASE; INSULIN RESISTANCE; INSULINOMA; MEMBRANE POTENTIAL; NONHUMAN; PANCREAS CELL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BASE SEQUENCE; CELL DIVISION; CELL SURVIVAL; CHROMANS; DNA PRIMERS; FATTY ACIDS, NONESTERIFIED; INSULIN; INSULINOMA; KINETICS; LINOLEIC ACID; OLEIC ACID; PALMITIC ACID; PANCREATIC NEOPLASMS; PEROXISOMES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0036122477     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(01)00367-9     Document Type: Conference Paper

References (45)

1. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
2. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
3. 12,14 prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
4. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation
5. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor
6. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor gamma ligand troglitazone in patients with liposarcoma
7. Terminal differentiation of human breast cancer through PPAR gamma
8. Differentiation and reversal of malignant changes in colon cancer through PPAR gamma
9. Min/+ mice
10. Activators of the nuclear receptor PPAR gamma enhance colon polyp formation
11. PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor
12. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
13. Effects of troglitazone on fat distribution in the treatment of male type 2 diabetes
14. Characterization of new oral anti-diabetic agent CS-045; studies in KK and ob/ob mice and Zucker fatty rats
15. Effects of a new oral hypoglycemic agent (CS-045) on metabolic abnormalities and insulin resistance in type 2 diabetes
16. Metabolic effects of new oral hypoglycemic agent troglitazone in NIDDM subjects
17. Effects of troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: An insulinotropic mechanism distinct from glibenclamide
18. 2+ influx
19. Troglitazone (CS-045) inhibits β-cell proliferation rate following stimulation of insulin secretion in HIT-T 15 cells
20. Characterization of CS-045, a new oral antidiabetic agent, II. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in C57BL/KsJ-db/db mice
21. Treatment with the oral antidiabetic agent troglitazone improves β cell responses to glucose in subjects with impaired glucose tolerance
22. Cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-β-cell relationships
23. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM
24. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
25. Fatty acids, lipotoxicity and insulin secretion
26. The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation
27. 2+
28. Chronic effects of different fatty acids and leptin in INS-1 cells
29. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
30. Down regulation of peroxisome proliferator-activated receptor gamma expression by inflammatory cytokines and its reversal by thiazolidinediones
31. Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay
32. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
33. Lack of effect of CS-045, a new antidiabetic agent, on insulin secretion in the remnant pancreas after 90% pancreatectomy in rats
34. Effect of troglitazone on B cell function, insulin sensitivity, and glycemic control in subjects with type 2 diabetes mellitus
35. Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats
36. Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma
37. + channels in pancreatic B-cells
38. Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells
39. 2+ influx in rat pancreatic β-cell
40. 2+
41. 2+ in rat pancreatic islets
42. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion
43. Troglitazone but not pioglitazone affects ATP-sensitive K(+) channel activity
44. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
45. +-ATP channel-independent pathway of regulation of insulin secretion by glucose