Considerations when analyzing the methylation status of PTEN tumor suppressor gene

American Journal of Pathology

Volumn 160, Issue 3, 2002, Pages 795-800

  Zysman, Michele A ^a   Chapman, William B ^b,c   Bapat, Bharati ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; COLON CANCER; CONTROLLED STUDY; DNA METHYLATION; ENDOMETRIUM CANCER; GENE MUTATION; GENE SEQUENCE; GENE SILENCING; HAMARTOMA; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PSEUDOGENE; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

EID: 0036121266     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64902-4     Document Type: Article

References (23)

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2. Germ-line mutations in PTEN are present in Bannayan-Zonana syndrome
3. PTEN gene mutations are seen in high-grade but not in low-grade gliomas
4. Epigenetic PTEN silencing in malignant melanomas without PTEN mutation
5. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
6. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas
7. Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors
8. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
9. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
10. Gatekeeper for endometrium: The PTEN tumor suppressor gene
11. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
12. PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma
13. Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation
14. Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer
15. Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas
16. hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis
17. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
18. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
19. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
20. A highly conserved processed PTEN pseudogene is located on chromosome band 9p21
21. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
22. Pten, a protean tumor suppressor
23. PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma