Behavioral effects of the selective blockade of metabotropic glutamate receptor subtype 5 in experimental hypoxia

Polish Journal of Pharmacology

Volumn 54, Issue 2, 2002, Pages 95-102

  Nadlewska, Agnieszka ^a   Car, Halina ^a   Wísniewska, Róza J ^a   Wiśniewski, Konstanty ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

2 methyl 6 (phenylethynyl) pyridine; Elevated "plus" maze test; Hypoxia; Locomotion; Passive avoidance; Rats

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG EFFECT; EXPLORATORY BEHAVIOR; HYPOXIA; LOCOMOTION; MALE; MAZE TEST; MEMORY CONSOLIDATION; NONHUMAN; OPEN FIELD TEST; PASSIVE AVOIDANCE; RAT;

ANIMALS; ANOXIA; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; INJECTIONS, INTRAVENOUS; MALE; MAZE LEARNING; MOTOR ACTIVITY; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0036113758     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Retention of a passive avoidance responses as a function of the intensity and duration of the electric shock
2. Effects of hypoxia on memory consolidation: Implications for a multistage model of memory
3. Glutamate in the human brain: Possible roles in synaptic transmission and ischemia
4. Antagonists of the metabotropic glutamate receptor do not prevent induction of long-term potentiation in the dentate gyrus of rats
5. Involvement of mGluR(5) in acute nociceptive transmission
6. Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective
7. 7]AVP on learning and memory processes in rats with experimental amnesia
8. 2]AVP on memory process in rats with experimental amnesia
9. AIDA influences behavior in rats pretreated with baclofen
10. The effect of baclofen and AIDA on behavior of rats after hypoxia
11. Baclofen prevents hypoxia-induced consolidation impairment for passive avoidance in rats
12. The class I metabotropic glutamate receptor antagonist, AIDA, improves short-term and impairs long-term memory in a spatial task for rats
13. Task-specific enhancement of short-term, but not long-term memory by class I metabotropic glutamate receptor antagonist 1-aminoindan-1,5-dicarboxylic acid in rats
14. Pharmacology and functions of metabotropic glutamate receptors
15. Oxidative stress, glutamate and neurodegenerative disorders
16. Synapse structure: Glutamate receptors connected by the shanks
17. In vivo antinociceptive activity of anti-rat mGluR 1 and mGluR 5 antibodies in rats
18. Methyl-phenylethynylpyridine (MPEP): A novel potent subtype-selective and systemically active antagonist at metabotropic glutamate receptor subtype 5
19. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
20. Metabotropic glutamate receptor acivation and blokade: Their role in long-term potentiation, learning and neurotoxicity
21. Pharmacology of learning and memory
22. Effects of hypoxia on the activities of noradrenergic and dopaminergic neurons in the rat brain
23. mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors
24. Molecular diversity of glutamate receptors and implications for brain function
25. Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats
26. 1-Aminoindan-1,5-dicarboxylic acid and (S)--(+)-2-carboxybicyclo [1.1.1.]pentyl-glicyne, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro models of cerebral ischaemia
27. Metabotropic G-protein-coupled glutamate receptors as therapeutic targets
28. Validation of open: Closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
29. Temporal profile of neuronal damage in a model of transient forebrain ischemia
30. Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil
31. Metabotropic glutamate receptors in hippocampal long-term potentiation and learning and memory
32. The hippocampus is necessary for rats to learn and remember configural discriminations
33. Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions
34. Metabotropic glutamate receptors in brain function and pathology
35. Pharmacological agents acting at subtypes of metabotropic glutamate receptors
36. Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats
37. Novel allosteric antagonists shed light on mGlu5 receptors and CNS disorders
38. Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonists 2-methyl-6-(phenylethynyl) pyridine in rodents
39. Selective blockade of mGlu5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage