Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate

Biochemistry

Volumn 39, Issue 13, 2000, Pages 3556-3564

  Cody, Vivian ^a   Chan, David ^c   Galitsky, Nikolai ^a   Rak, Dawn ^a   Luft, Joseph R ^a   Pangborn, Walter ^a   Queener, Sherry F ^b   Laughton, Charles A ^c   Stevens, Malcolm F G ^c  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINOPYRIMIDINE DERIVATIVE; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; PYRIMETHAMINE; PYRIMIDINE DERIVATIVE; TRIMETREXATE;

ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG CONFORMATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID ANTAGONISTS; MODELS, MOLECULAR; NADP; PNEUMOCYSTIS; PROTEIN CONFORMATION; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS; TRIAZENES; TRIMETHOPRIM;

PNEUMOCYSTIS CARINII;

EID: 0034603859     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9924563     Document Type: Article

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