Identification of B cell epitopes of hepatitis C virus RNA dependent RNA polymerase

Journal of Virological Methods

Volumn 104, Issue 1, 2002, Pages 1-8

  Hou, Lihua ^a   Du, Guixin ^a   Tong, Yigang ^a   Wang, Haitao ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

ELISA; Epitope; Hepatitis C virus (HCV); Phage displayed peptide library; pIII protein

Indexed keywords

AMINO ACID; ANTIBODY; EPITOPE; HYBRID PROTEIN; RECOMBINANT PROTEIN; RNA POLYMERASE; SEPHAROSE; VIRUS PROTEIN; VIRUS RNA;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; ANALYTIC METHOD; ANTIBODY SPECIFICITY; ANTIGENICITY; ARTICLE; B LYMPHOCYTE; BACTERIOPHAGE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; HEPATITIS C VIRUS; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

AMINO ACID SEQUENCE; ANTIBODIES, VIRAL; EPITOPE MAPPING; EPITOPES, B-LYMPHOCYTE; HEPACIVIRUS; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; RNA REPLICASE; VIRAL NONSTRUCTURAL PROTEINS;

ESCHERICHIA COLI; HEPATITIS C VIRUS;

EID: 0036096186     PISSN: 01660934     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-0934(02)00006-X     Document Type: Article

References (19)

1. National Institutes of Health Consensus Development Conference Panel statement: Management of hepatitis C
2. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
3. Primary structure and variation of Chinese hepatitis C virus genome
4. Crystal structure of RNA-dependent RNA polymerase of hepatitis C virus
5. Isolation of cDNA clone derived from a blood-borne non-A non-B viral hepatitis genome
6. Hepatitis C virus diagnostics: Technology, clinical applications and impacts
7. Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli
8. Expression and identification of hepatitis C virus polyprotein cleavage products
9. Hepatitis C virus NS5B protein is a membrane-associated phosphoprotein with a predominantly perinuclear localization
10. Linear B cell epitopes of the NS2-NS4-NS5 proteins of the hepatitis C virus as modeled with synthetic peptides
11. Crystal structure of RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
12. Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
13. Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of hepatitis C virus
14. The measurement of relative antibody affinity by ELISA using thiocyanate elution
15. Identification of antigenic sites on three hepatitis C virus proteins using phage-displayed peptide libraries
16. Hepatitis C virus from phage-displayed cDNA libraries and improved diagnosis with a chimeric antigen
17. Selection of antigenic and immunogenic mimics of hepatitis C virus using sera from patients
18. Characterization of the antibody reactivity to synthetic peptides from different parts of the hepatitis C virus genome
19. Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence