Characterization of the antibody reactivity to synthetic peptides from different parts of the hepatitis C virus genome

Viral Immunology

Volumn 9, Issue 2, 1996, Pages 89-96

  Pujol, Flor H ^a   Khudyakov, Yury E ^b   Devesa, Marisol ^a   León, Graciela ^c   Blitz Dorfman, Linda ^d   Monsalve, Francisca ^d   Lambert, Steve B ^b   Kalinina, Tatiana Y ^b   Liprandi, Ferdinando ^a   Fields, Howard A ^b  

^a Instituto Venezolano de Investigaciones Cientificas Centro de Microbiologia y Biologia Celular   (Venezuela)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c Banco Munic Sangre Distrito F   (Venezuela)

^d UNIVERSIDAD DEL ZULIA   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE;

ANTIBODY RESPONSE; ANTIGEN ANTIBODY REACTION; ARTICLE; BLOOD DONOR; ENZYME IMMUNOASSAY; HEMODIALYSIS; HEPATITIS C VIRUS; HUMAN; VIRUS GENOME;

HEPATITIS C VIRUS; NON-A, NON-B HEPATITIS VIRUS;

EID: 0029973339     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.1996.9.89     Document Type: Article

References (23)

1. Benjamin, D.C., J.A. Berzofsky, I.J. East, F.R.N. Gurd, C. Hannum, S.J. Leach, E. Margoliash, J.G. Michael, A. Miller, E.M. Prager, M. Reichlin, E.E. Sercarz, S.J. Smith-Gill, P.E. Todd, and A.C. Wilson. 1984. The antigenic structure of proteins: A reappraisal. Annu. Rev. Immunol. 2:67-101.
2. Ching, W.-M., C. Wychowski, M. Beach, H. Wang, C.L. Davies, M. Carl, D.W. Bradley, H.J. Alter, S.M. Feinstone, and J.W.-K. Shih. 1992. Interaction of immune sera with synthetic peptides corresponding to the structural protein region of hepatitis C virus. Proc. Natl. Acad. Sci. U.S.A. 89:3190-3194.
3. Dusheiko, G., H. Schmilovitz-Weiss, D. Brown, F. McOmich, P.-L. Yap, S. Sherlock, N. McIntyre, and P. Simmonds. 1994. Hepatitis C virus genotypes: An investigation of type-specific differences in geographic origin and disease. Hepatology 19:13-18.
4. Garson, J.A., and R.S. Tedder. 1993. The detection of hepatitis C infection. Rev. Med. Virol. 3:75-83.
5. Hosein, B., C.T., Fang, M.A. Popovsky, J. Ye, M. Zhang, and C.Y. Wang. 1991. Improved serodiagnosis of hepatitis C virus infection with synthetic peptide antigen from capsid protein. Proc. Natl. Acad. Sci. U.S.A. 88:3647-3651.
6. Kato, N., M. Hijikata, Y. Ootsuyama, M. Nakagawa, S. Ohkoshi, T. Sugimura, and K. Shimtono. 1990. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc. Natl. Acad. Sci. U.S.A. 87:9524-9528.
7. Khudyakov, Y.E., N.S. Khudyakova, D.L. Jue, S.B. Lambert, S. Fang, and H.A. Fields. 1995. Linear B- cell epitopes of the NS3-NS4-NS5 proteins of the hepatitis C virus as modeled with synthetic peptides. Virology 206:666-672.
8. Khudyakov, Y.E. Unpublished results.
9. Khudyakov, Y.E., M.O. Favopovu, T.I. Halinina, D. Juc, T.K. Hine, and M.A. Fields. In preparation.
10. Lau, J.Y.N., G.L. Davis, E. Orito, K.P. Qian, and M. Mizokami. 1993. Significance of antibody to the host cellular gene derived epitope GOR in chronic hepatitis C virus infection. J. Hepatol. 17:253-257.
11. Machado, I.V., L. Deibis, E. Risquez, P. Tassinari, M. Zabaleta, F. Toro, M.L. Baroja, J. Corado, I. Blanca, G. Echevarría, and N.E. Bianco. 1994. Immunoclinic, molecular and immunopathologic approach of chronic viral hepatitis. GEN 48:124-132.
12. Mondelli, M.U., A. Cerino, F. Bono, A. Cividini, A. Maccabruni, M. Arico, A. Malfitano, G. Barbarini, V. Piazza, L. Minoli, and E. Silini. 1994. Hepatitis C virus (HCV) core serotypes in chronic HCV infection. J. Clin. Microbiol. 32:2523-2527.
13. Okamoto, H., H. Tokita, M. Sakamoto, M. Horikita, M. Kojima, H. Iizuka, and S. Mishiro. 1993. Characterization of the genome sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection. J. Gen. Virol. 74:2385-2390.
14. Pujol, F.H., A. Bertolotti, H.A. Fields, Y.E. Khudyakov, T. Kalinina, and F. Liprandi. 1994. A monoclonal inhibition enzyme immunoassay for detection of antibodies against hepatitis B core antigen: Confirmation of an immunodominant epitope. J. Immunoassay 15:239-249.
15. Pujol, F.H., L. Blitz-Dorfman, G. León, F. Monsalve, J.M. Echevarría, and F. Liprandi. 1995. Efficacy of different second- and third-generation assays for detection of hepatitis C virus antibodies in plasma and sera also tested by polymerase chain reaction. Serod. Immunother. Infect. Dis. 7:51-54.
16. Sällberg, M., U. Rudén, B. Wahren, and L.O. Magnius. 1992. Immunodominant regions within the hepatitis C virus core and putative matrix protein. J. Clin. Microbiol. 30:1989-1994.
17. Sällberg, M., P. Pumpen, Z.-X. Zhang, P. Lundholm, I. Gusars, U. Rudén, B. Wahren, and L.O. Magnius. 1994. Locations of antibody binding sites within conserved regions of the hepatitis C virus core protein. J. Med. Virol. 43:62-68.
18. Sato, A., Y. Sho, H. Nakamura, T. Kunitomo, and T. Arima. 1994. Immune response of blood donors to peptides of various lengths and those with genotypic sequence variations corresponding to the N-terminal portion of the core protein of hepatitis C virus. J. Med. Virol. 44:88-91.
19. Simmonds, P., K.A. Rose, S. Graham, S.-W. Chan, F. McOmish, B.C. Dow, E.A.C. Follett, P.L. Yap, and H. Marsden. 1993. Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): Use of type-specific peptides to serologically differentiate infections with HCV types 1, 2 and 3. J. Clin. Microbiol. 31:1493-1503.
20. Taliani, G., R. Leece, M.C. Badolato, A. Bozza, G. Poliandri, C. Furlan, R. Bruni, C. Clementi, and C. De Bac. 1994. Anti-GOR antibodies in anti-hepatitis C virus positive subjects with and without virus replication and liver disease. J. Hepatol. 20:845.
21. Thiers, V., F. Lunel, D. Valla, N. Azar, C. Fretz, L. Frangeul, J.-M. Huraux, P. Opolon, and C. Brechot. 1993. Post-transfusional anti-HCV negative non-A non-B hepatitis (II) serological and polymerase chain reaction analysis for hepatitis C and hepatitis B viruses. J. Hepatol. 18:34-39.
22. Van Doorn, L.-J., B. Kleter, L. Stuyver, G. Maertens, H. Brouwer, S. Schalm, R. Hejtink, and W. Quint. 1994. Analysis of hepatitis C virus genotypes by a line probe assay and correlation with antibody profiles. J. Hepatol. 21:122-129.
23. Zhang, Z.-X., M. Chen, A. Sonnenberg, O. Weiland, and M. Sällberg. 1995. Distinguishing acute from symptomatic chronic hepatitis C virus (HCV) infection by site-directed serology of the structural proteins. J. Infect. Dis. 171:1356-1359.