Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations

Clinical Cancer Research

Volumn 5, Issue 12, 1999, Pages 4085-4090

  Raffel, Corey ^a   Frederick, Lori ^a   O'Fallon, Judith R ^a   Atherton Skaff, Pamela ^a   Perry, Arie ^b   Jenkins, Robert B ^a   James, C David ^a  

^a MAYO CLINIC   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ASTROCYTOMA; CANCER GRADING; DIFFERENTIAL DIAGNOSIS; GENE MUTATION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ASTROCYTOMA; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; MUTATION; ONCOGENES; PHOSPHORIC MONOESTER HYDROLASES; PROGNOSIS; PTEN PHOSPHOHYDROLASE; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 0033398991     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Darling, J. L., and Warr, T. J. Biology and genetics of malignant brain tumours. Curr. Opin. Neurol., 11: 619-625, 1998.
2. Ng, H. K., and Lam, P. Y. The molecular genetics of central nervous system tumors. Pathology, 30: 196-202, 1998.
3. Pollack, I. Current concepts: brain tumors in children. N. Engl. J. Med., 331: 1500-1507, 1994.
4. Finlay, J. L. Chemotherapeutic strategies for high-grade astrocytomas of childhood. In: R. J. Packer, W. A. Bleyer, and C. Pochedly (eds.), Pediatric Neuro-Oncology, Vol. 3, pp. 176-206. Chur, Switzerland: Harwood Academic Publishers, 1992.
5. Rasheed, B. K., McLendon, R. E., Herndon, J. E., Friedman, H. S., Friedman, A. H., Bigner, D. D., and Bigner, S. H. Alterations of the TP53 gene in human gliomas. Cancer Res., 54: 1324-1330, 1994.
6. Litofsky, N. S., Hinton, D., and Raffel, C. The lack of a role for p53 in astrocytomas in pediatric patients. Neurosurgery, 3: 967-972, 1994.
7. Felix, C. A., Slavec, I., Dunn, M., Strauss, E. A., Phillips, P. C., Rorke, L. B., Sutton, L., Bunin, G. R., and Biegel, J. A. p53 gene mutations in pediatric brain tumors. Med. Ped. Oncol., 25: 431-436, 1995.
8. Pollack, I. F., Hamilton, R. L., Finkelstein, S. D., Campbell, J. W., Martinez, A. J., Sherwin, R. N., Bozik, M. E., and Gollin, S. M. The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood. Cancer Res., 57: 304-309, 1997.
9. Sure, U., Ruedi, D., Tachibana, O., Yonekawa, Y., Ohgaki, H., Kleihues, P., and Hegi, M. E. Determination of p53 mutations, EGFR overexpression, and loss of p 16 expression in pediatric glioblastomas. J. Neuropathol. Exp. Neurol., 56: 782-789, 1997.
10. Bhattacharjee, M. B., and Bruner, J. M. p53 protein in pediatric malignant astrocytomas: a study of 21 patients. J. Neuro-Oncol., 32: 225-233, 1997.
11. Salminen, E., Nuutinen, J. M., and Huhtala, S. Multivariate analysis of prognostic factors in 106 patients with malignant glioma. Eur. J. Cancer, 32A: 1918-1923, 1996.
12. Salcman, M., Scholtz, H., Kaplan, R. S., and Kulik, S. Long-term survival in patients with malignant astrocytoma. Neurosurgery, 34: 213-219, 1994.
13. Burns, K. L., Ueki, K., Jhung, S. L., Koh, J., and Louis, D. N. Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas. J. Neuropathol. Exp. Neurol., 57: 122-130, 1998.
14. Hunter, S. B., Abbott, K., Varma, V. A., Olson, J. J., Barnett, D. W., and James, C. D. Reliability of differential PCR for the detection of EGFR and MDM2 gene amplification in DNA extracted from FFPE glioma tissue. J. Neuropathol. Exp. Neurol., 54: 57-64, 1995.
15. Liu, W., James, C. D., Frederick, L., Alderete, B., and Jenkins, R. B. PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. Cancer Res., 57: 5254-5257, 1997.
16. Olson, J. J., Barnett, D., Yang, J., Assietti, R., Cotsonis, G., and James, C. D. Gene amplification as a prognostic factor in primary brain tumors. Clin. Cancer Res., 4: 215-222, 1998.
17. Sommer, S. S., Cunningham, J., McGovern, R. M., Saitoh, S., Schroeder, J. J., Wold, L. E., and Kovach, J. S. Pattern of p53 gene mutations in breast cancers of women of the midwestern United States. J. Natl. Cancer Inst., 84: 246-252, 1992.
18. Brat, D. J., James, C. D., Jedlicka, A. E., Connolly, D. C., Cho, K. R., Chang, E., Castellani, R. J., Schmid, M., Schiller, M., Carson, D. A., and Burger, P. C. Molecular genetic alterations in radiation-induced astrocytomas. Am. J. Pathol., 154: 1431-1438, 1999.
19. INK4A transcript. Cancer Res., 55: 2995-2997, 1995.
20. Wong, A. J., Bigner, S. H., Bigner, D. D., Kinzler, K. W., Hamilton, S. R., and Vogelstein, B. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc. Natl. Acad. Sci. USA, 84: 6899-6903, 1987. 21.
21. Ekstrand, A. J., James, C. D., Cavenee, W. K., Seliger, B., Pettersson, R. F., and Collins, V. P. Genes for epidermal growth factor receptor, transforming growth factor α, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res., 51: 2164-2172, 1991.
22. Schlegel, J., Merdes, A., Stumm, G., Albert, F. K., Forsting, M., Hynes, N., and Kiessling, M. Amplification of the epidermal-growth-factor-receptor gene correlates with different growth behaviour in human glioblastoma. Int. J. Cancer, 56: 72-77, 1994.
23. Oliner, J. D., Kinzler, K. W., Meltzer, P. S., George, D. L., and Vogelstein, B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (Lond.), 358: 80-83, 1992.
24. Zhang, Y., Xiong, Y., and Yarbrough, W. G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell, 92: 725-734, 1998.
25. Sidransky, D., Mikkelsen, T., Schwechheimer, K., Rosenblum, M. L., Cavanee, W., and Vogelstein, B. Clonal expansion of p53 mutant cells is associated with brain tumour progression. Nature (Lond.), 355: 846-847, 1992.
26. Fults, D., Brockmeyer, D., Tullous, M. W., Pedone, C. A., and Cawthon, R. M. p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression. Cancer Res., 52: 674-679, 1992.
27. Sonoda, Y., Yoshimoto, T., and Sekiya, T. Homozygous deletion of the MTS1/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma. Oncogene, 11: 2145-2149, 1995.
28. Ueki, K., Ono, Y., Henson, J. W., Efird, J. T., von Deimling, A., and Louis D. N. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res., 56: 150-153, 1996.
29. Rasheed, B. K., Stenzel, T. T., McLendon, R. E., Parsons, R., Friedman, A. H., Friedman, H. S., Bigner, D. D., and Bigner, S. H. PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Cancer Res., 57: 4187-4190, 1997.
30. Lin, H., Bondy, N. L., Langford, L. A., Hess, K. R., Delclos, G. L., Wu, X. F., Chan, W. Y., Pershouse, M. A., Yung, W. K. A., and Steck, P. A. Allelic deletion analyses of MMAC1/PTEN and DMBT1 loci in gliomas: relationship to prognostic significance. Clin. Cancer Res., 4: 2447-2454, 1998.
31. Cheng, Y., Ng, H. K., and Pang, J. Alterations of p53, PTEN, EGFR, chromosome 9p21 and microsatellite instability in pediatric high-grade astrocytomas. Proc. Am. Assoc. Cancer Res., 40: 3991, 1999.
32. Yang, W., Barth, R. F., Adams, D. M., and Soloway, A. H. Intratumoral delivery of boronated epidermal growth factor for neutron capture therapy of brain tumors. Cancer Res., 57: 4333-4339, 1997.
33. O'Rourke, D. M., Qian, X., Zhang, H. T., Davis, J. G., Nute, E., Meinkoth, J., and Greene, M. I. Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains. Proc. Natl. Acad. Sci. USA, 94: 3250-3255, 1997.
34. Wersall, P., Ohlsson, I., Biberfeld, P., Collins, V. P., von Krusenstjerna, S., Larsson, S., Mellstedt, H., and Boethius, J. Intratumoral infusion of the monoclonal antibody, mAb 425, against the epidermal-growth-factor receptor in patients with advanced malignant glioma. Cancer Immunol. Immunother., 44: 157-164, 1997.
35. Penar, P. L., Khoshyomn, S., Bhushan, A., and Tritton, T. R. Inhibition of epidermal growth factor receptor-associated tyrosine kinase blocks glioblastoma invasion of the brain. Neurosurgery, 40: 141-151, 1997.
36. Heise, C., Sampson-Johannes, A., Williams, A., McCormick, F., Von Hoff, D. D., and Kirn, D. H. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat. Med., J: 639-645, 1997.
37. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M., Eng, C., and Parsons, R. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16: 64-67, 1997.