Cellular immune responses against hepatitis C virus: The evidence base 2002

Clinical and Experimental Immunology

Volumn 128, Issue 2, 2002, Pages 195-203

  Ward, S ^a   Lauer, G ^b   Isba, R ^a   Walker, B ^b   Klenerman, P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

CD4+ T lymphocyte; CD8+ T lymphocyte; Epitope; HCV; HLA; Immune escape

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; HEPATITIS C VACCINE; HLA A2 ANTIGEN; HLA B27 ANTIGEN; VIRUS RNA;

ACUTE DISEASE; AMINO ACID SEQUENCE; CELLULAR IMMUNITY; HEPATITIS C; HEPATITIS C VIRUS; HOST RESISTANCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; INCIDENCE; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; REVIEW; RNA VIRUS; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TIME;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; HEPACIVIRUS; HEPATITIS C; HUMANS; IMMUNITY, CELLULAR; VIRAL VACCINES;

EID: 0036094284     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2002.01840.x     Document Type: Review

References (79)

1. The epidemic behavior of the hepatitis C virus
2. Hepatitis C virus infection
3. Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection
4. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
5. Primary interferon resistance and treatment response in chronic hepatitis C infection: A pilot study
6. Hepatitis C virus. The importance of viral heterogeneity
7. Determinants of viral clearance and persistence during acute hepatitis C virus infection
8. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies
9. + T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained
10. Analysis of successful immune responses in persons infected with hepatitis C virus
11. Recurrence of hepatitis C virus after loss of virus-specific CD4 (+) T-cell response in acute hepatitis C
12. Hepatitis C virus-specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C
13. Possible mechanism involving T-lymphocyte response to nonstructural protein 3 in viral clearance in acute hepatitis C virus infection
14. Analysis of a successful immune response against hepatitis C virus
15. Hepatitis C virus-specific CD4 (+) T cells. Do they help or damage?
16. Immunobiology of hepatitis C virus (HCV) infection: The role of CD4 T cells in HCV infection
17. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response
18. Influence of MHC class II genotype on outcome of infection with hepatitis C virus
19. Effect of HLA class II genotype on T helper lymphocyte responses and viral control in hepatitis C virus infection
20. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C
21. Liver-derived CTL in hepatitis C virus infection. Breadth and specificity of responses in a cohort of persons with chronic infection
22. Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection
23. Recognition of a novel naturally processed, A2 restricted, HCV-NS4 epitope triggers IFN-gamma release in absence of detectable cytopathicity
24. Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules
25. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif
26. Vigorous peripheral blood cytotoxic T cell response during the acute phase of hepatitis C virus infection
27. Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients
28. Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection
29. + T cells in hepatitis C virus-exposed healthy seronegative donors
30. Identification of A2-restricted hepatitis C virus-specific cytotoxic T lymphocyte epitopes from conserved regions of the viral genome
31. Comparison of cytotoxic T-lymphocyte responses to hepatitis C virus core protein in uninfected and infected individuals
32. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus
33. Differential CD4 (+) and CD8 (+) T-cell responsiveness in hepatitis C virus infection
34. Virus-specific CD8 (+) T cells with type 1 or type 2 cytokine profile are related to different disease activity in chronic hepatitis C virus infection
35. Generation of hepatitis C virus-specific cytotoxic T lymphocytes from healthy individuals with peptide-pulsed dendritic cells
36. Enhanced in vitro potency and in vivo immuno-genicity of a CTL epitope from hepatitis C virus core protein following amino acid replacement at secondary HLA-A2.1 binding positions
37. An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans
38. CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1
39. Characterization of an immunologically conserved epitope from hepatitis C virus E2 glycoprotein recognized by HLA-A2 restricted cytotoxic T lymphocytes
40. Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C
41. Identification of immunodominant hepatitis C virus (HCV) -specific cytotoxic T-cell epitopes by stimulation with endogenously synthesized HCV antigens
42. Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity
43. Quantitative analysis of hepatitis C virus-specific CD8 (+) T cells in peripheral blood and liver using peptide-MHC tetramers
44. HLA class-I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release
45. Hepatitis C virus-specific cytolytic T lymphocyte and T helper cell responses in seronegative persons
46. Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV
47. Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus
48. Use of recombinant protein to identify a motif-negative human cytotoxic T-cell epitope presented by HLA-A2 in the hepatitis C virus NS3 region
49. Inefficient recognition of autologous viral sequences by intrahepatic hepatitis C virus-specific cytotoxic T lymphocytes in chronically infected subjects
50. Hepatitis C virus (HCV) -specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV
51. Three new cytotoxic T cell epitopes identified within the hepatitis C virus nucleoprotein
52. Identification of HLA-A3 and - B7-restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C
53. Perforin, Fas/Fas ligand, and TNF-alpha pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL
54. HLA B44-restricted cytotoxic T lymphocyte responses to the peptides of HCV nucleoprotein residues 81-100 in patients with chronic hepatitis C
55. A minimal and optimal cytotoxic T cell epitope within hepatitis C virus nucleoprotein
56. Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection
57. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis
58. Identification and characterization of a cytotoxic T cell epitope of hepatitis C virus presented by HLA-B*3501 in acute hepatitis
59. A novel cytotoxic T-cell epitope presented by HLA-A24 molecule in hepatitis C virus infection
60. Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells
61. HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides
62. Why do cytotoxic T lymphocytes fail to eliminate hepatitis C virus?
63. Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography
64. Life, activation and death of intrahepatic lymphocytes in chronic hepatitis C
65. Predicting the dynamics of antiviral cytotoxic T-cell memory in response to different stimuli: Cell population structure and protective function
66. Peripheral clonal deletion of antiviral memory CD8+ T cells
67. Death and destruction of activated T lymphocytes
68. Impaired anti-viral T cell responses due to expression of the Ly49A inhibitory receptor
69. Critical role for alpha/ beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells
70. The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus
71. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
72. Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses
73. Evolution and transmission of stable CTL escape mutations in HIV infection
74. Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo
75. Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
76. Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus
77. Viral persistence in vivo through selection of neutralizing antibody-escape variants
78. Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes
79. Viral escape and the failure of cellular immune responses