Impaired anti-viral T cell responses due to expression of the LY49A inhibitory receptor

Journal of Immunology

Volumn 163, Issue 10, 1999, Pages 5526-5534

  Zajac, Allan J ^a,b   Vance, Russell E ^c   Held, Werner ^c,d   Sourdive, David J D ^b,e   Altman, John D ^b   Raulet, David H ^c   Ahmed, Rafi ^b,f  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b EMORY UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

^e CENTRE D ETUDES DU BOUCHET   (France)

^f EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; IMMUNOREACTIVITY; IMMUNOREGULATION; INFECTION RESISTANCE; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSGENIC MOUSE; VIRUS RESISTANCE;

ANIMALS; ANTIGENS, LY; CARRIER PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CYTOKINES; H-2 ANTIGENS; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0033571102     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Ljunggren, H. G., and K. Kärre. 1990. In search of the 'missing self: MHC molecules and NK cell recognition. Immunol. Today 11:237.
2. Höglund, P., J. Sundbäck, M. Y. Olsson-Siheim, M. Salcedo, C. Öhlén, H.-G. Ljunggren, C. L. Sentman, and K. Kärre. 1997. Host MHC class I gene control of NK-cell specificity in the mouse. Immunol. Rev. 155:11.
3. Lanier, L. L. 1998. NK cell receptors. Annu. Rev. Immunol. 16:359.
4. Yokoyama, W. M. 1995. Natural killer cell receptors specific for major histocompatibility complex class I molecules. Proc. Natl. Acad. Sci. USA 92:3081.
5. Braud, V. M., D. S. J. Allan, C. A. O'Callaghan, K. Soderstrom, A. D'Andrea, G. S. Ogg, S. Lazetic, N. T. Young, J. I. Bell, J. H. Phillips, L. L. Lanier, and A. J. McMichael. 1998. HLA-E binds to natural killer cell receptors CD94/ NKG2A, B, and C. Nature 391:795.
6. Borrego, F., M. Ulbrecht, E. H. Weiss, J. E. Coligan, and A. G. Brooks. 1998. Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. J. Exp. Med. 187:813.
7. Lee, N., M. Llano, M. Carretero, A. Ishitani, F. Navarro, M. Lopez-Botet, and D. E. Geraghty. 1998. HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proc. Natl. Acad. Sci. USA 95:5199.
8. b. J. Exp. Med. 16:1841.
9. Brutkiewicz, R. R., and R. M. Welsh. 1995. Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells. J. Virol. 69:3967.
10. Ehrlich, R. 1997. Modulation of antigen processing and presentation by persistent virus infections and in tumors. Hum. Immunol. 54:104.
11. + natural killer cells: role in cell activation and regulation of cytolytic function. J. Exp. Med. 171:695.
12. Ferrini, S., A. Cambiaggi, R. Meazza, S. Sforzini, S. Marciano, S. Mingari, and L. Moretta, 1994. T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function. Eur. J. Immunol. 24:2294.
13. Phillips, J. H., J. E. Gumperz, P. Parham, and L. L. Lanier. 1995. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. Science 268:403.
14. D'Andrea, A., C. Chang, J. H Phillips, and L. L. Lanier. 1996. Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. J. Exp. Med. 184:789.
15. Mingari, M. C., A. Moretta, and L. Moretta. 1998. Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses. Immunol. Today 19:153.
16. De Maria, A., A. Ferraris, M. Guastella, S. Pilia, C. Cantoni, L. Polero, M. C. Mingari, D. Bassetti, A. S. Fauci, and L. Moretta. 1997. Expression of HLA class I-specific inhibitory natural killer cell receptors in HIV-specific cytolytic T lymphocytes: impairment of specific cytolytic functions. Proc. Natl. Acad. Sci. USA 94:10285.
17. Ikeda, H., B. Lethe, F. Lehmann, N. Van Baren, J.-F. Baurain, C. De Smet, H. Chambost, M. Vitlae, A. Moretta, T. Boon, and P. G. Coulie. 1997. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. Immunity 6:199.
18. + cells. J. Immunol. 160:1158.
19. Held, W., D. Cado, and D. H. Raulet. 1996. Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection. J. Exp Med. 184:2037.
20. + IL-2 activated natural killer cells. Nature 358:66.
21. Held, W., and D. H. Raulet. 1997. Ly49A transgenic mice provide evidence for a major histocompatibility complex-dependent education process in NK cell development. J. Exp. Med. 185:2079.
22. Buchmeier, M. J., and A. J. Zajac. 1999. Lymphocytic choriomeningitis virus. In Persistent Viral Infections. R. Ahmed and I. S. Y. Chen, eds. John Wiley & Sons, Chichester, U.K., p575.
23. Borrow P., and M. B. A. Oldstone. 1997. Lymphocytic choriomeningitis virus. In Viral Pathogenesis. N. Nathanson, ed. Lippincott-Raven Press, Philadelphia, p. 593.
24. 2-microglobulin deficient mice. Int. Immunol. 7:1545.
25. Lau, L. L., B. D. Jamieson, T. Somasundaram, and R. Ahmed. 1994. Cytotoxic T-cell memory without antigen. Nature 369:648.
26. + memory T-cells in virus-infected hosts. J. Exp. Med. 183:1367.
27. + T cells during an acute virus infection. Immunity 8:167.
28. Murali-Krishna, K., J. D. Altman, M. Suresh, D. J. D. Sourdive, A. J. Zajac, J. D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T-cells: a reevaluation of bystander activation during chronic viral infection. Immunity 8:177.
29. Murali-Krishna, K., J. D. Altman, M. Suresh, D. Sourdive, A. Zajac and R. Ahmed. 1998. In vivo dynamics of anti-viral CD8 T cell responses to different epitope: an evaluation of bystander activation in primary and secondary responses to viral infection. Adv. Expt. Med. Biol. 452:123.
30. + T lymphocytes mediate clearance of virus and regulate antiviral antibody responses. J. Virol. 61:1867.
31. + T-helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses. J. Virol. 62:2102.
32. Kägi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K. J. Olsem, E. R. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31.
33. Walsh, C. M., M. Matloubian, C.-C. Liu, R. Ueda, C. G. Kurahara, J. L. Christensen, M. T. Huang, J. D. Young, R. Ahmed, and W. R. Clark. 1994. Immune function in mice lacking the perforin gene. Proc. Natl. Acad. Sci. USA 91:10854.
34. Ahmed R, A. Salmi, L. D. Butler, J. Chiller, and M. B. A Oldstone. 1984. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice: role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 60:521.
35. Matloubian, M., S. R. Kolhekar, T. Somasundaram, and R. Ahmed. 1993. Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerizes and glycoprotein of lymphocytic choriomeningitis virus. J. Virol. 67:7340.
36. van der Most R. G., A. Sette, C. Oseroff, J. Alexander, K. Murali-Krishna, L. L. Lau, S. Southwood, J. Sidney, R. W. Chesnut, M. Matloubian, and R. Ahmed. 1996. Analysis of cytotoxic T-cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J. Immunol. 157:5543.
37. d-restricted subdominant cytotoxic T-cell responses in lymphocytic choriomeningitis virus-infected mice. Virology 240:158.
38. Sourdive, D. J., K. Murali-Krishna, J. D. Altman, A. J. Zajac, J. K. Whitmire, C. Pannetier, P. Kourilsky, B. Evavold, A. Sette, and R. Ahmed. 1998. Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection. J. Exp. Med. 188:71.
39. Yokoyama, W. M., and W. E. Seaman. 1993. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu. Rev. Immunol. 11:613.
40. Budd, R. C., J.-C. Cerottini, C. Hovath, C. Bron, T. Pedrazzini, R. C. Howe, and H. R. MacDonald. 1987. Distinction of virgin and memory T lymphocytes: stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation. J. Immunol. 138:3120.
41. + T-cells. Scand. J. Immunol. 42:110.
42. + cytotoxic T-cell responses during chronic viral infection. J. Virol. 68:8056.
43. + cells but markedly decreased helper activity in mice lacking CD4. Nature 353:180.
44. Daniels, B. F., F. M. Karlhofer, W. E. Seaman, and W. M. Yokoyama. 1994. A natural killer cell receptor specific for a major histocompatibility complex class I molecule. J. Exp. Med 180:687.
45. Brennan, J., G. Mahon, D. L. Mager, W. A. Jefferies, and F. Takei. 1996. Recognition of class I major histocompatibility complex molecules by Ly-49 - specificities and domain interactions. J. Exp. Med. 183:1553.
46. Hanke, T., H. Takizawa, C. W. MaMahon, D. H. Busch, E. G. Pamer, J. D. Miller, J. D. Altman, Y. Liu, D. Cado, F. A. Lemonnier, P. J. Bjorkman and D. H. Raulet. 1999. Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11:67.
47. Irving, B. A., F. W. Alt, and N. Killeen. 1998. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science 280:905.