Characterization of an immunologically conserved epitope from hepatitis C virus E2 glycoprotein recognized by HLA-A2 restricted cytotoxic T lymphocytes

Journal of Hepatology

Volumn 34, Issue 2, 2001, Pages 321-329

  Sarobe, Pablo ^a   Huarte, Eduardo ^a   Lasarte, Juan José ^a   López Díaz de Cerio, Ascensión ^a   García, Nicolás ^a   Borrás Cuesta, Francisco ^a   Prieto, Jesús ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Cytotoxic T lymphocytes; Epitope; Hepatitis C virus; HLA binding

Indexed keywords

CD8 ANTIGEN; HLA A2 ANTIGEN; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; VIRUS PEPTIDE E2(614-622); VIRUS PROTEIN;

ANTIGEN RECOGNITION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; EPITOPE MAPPING; HEPATITIS C VIRUS; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTIGENS, VIRAL; CELL LINE; CONSERVED SEQUENCE; EPITOPES; HEPACIVIRUS; HEPATITIS C, CHRONIC; HLA-A2 ANTIGEN; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; T-LYMPHOCYTES, CYTOTOXIC; VIRAL ENVELOPE PROTEINS;

EID: 0035110694     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)00018-0     Document Type: Article

References (37)

1. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
2. Non-A, non-B hepatitis. I. Recognition, epidemiology, and clinical features
3. Confirmation of hepatitis C virus infection by new four-antigen recombinant immunoblot assay
4. T-lymphocyte response to hepatitis C virus in different clinical courses of infection
5. + T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C
6. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection
7. + T lymphocyte epitopes of hepatitis C virus antigens and their relevance during the course of chronic infection
8. Interferon gamma production by peripheral blood lymphocytes to hepatitis C virus core protein in chronic hepatitis C infection
9. Production of interleukin-2 in response to synthetic peptides from hepatitis C virus El protein in patients with chronic hepatitis C: Relationship with the response to interferon treatment
10. Cellular immunity to hepatitis C virus core protein and the response to interferon in patients with chronic hepatitis C
11. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis
12. Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV
13. Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules
14. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif
15. An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans
16. A minimal and optimal cytotoxic T cell epitope within hepatitis C virus nucleoprotein
17. Use of recombinant protein to identify a motif-negative human cytotoxic T-cell epitope presented by HLA-A2 in the hepatitis C vires NS3 region
18. Analysis of a successful immune response against hepatitis C virus
19. Hepatitis C, virus-specific cytolytic T lymphocyte and T helper cell responses in seronegative persons
20. + T cells in hepatitis C virus-exposed healthy seronegative donors
21. Antigen recognition by class 1-restricted T lymphocytes
22. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
23. CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.I
24. Identification of A2-restricted hepatitis C virus-specific cytotoxic T lymphocyte epitopes from conserved regions of the viral genome
25. Identification of HLA-A3 and -B7-restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C
26. Insights on the amino acid side-chain interactions of a synthetic T-cell determinant
27. Enhanced in vitro potency and in vivo immunogenicity of a CTL epitope from hepatitis C vires core protein following amino acid replacement at secondatT HLA-A2.1 binding positions
28. Classification of hepatitis C vires into six major genotypes and a series of subtypes by phylogenetie analysis of the NS-5 region
29. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus
30. Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C vires epitope
31. Hepatitis C, et al. virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity
32. Hypervariable region I variants act as TCR antagonists for hepatitis C virus-specific CD4 + T cells
33. Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo
34. Peptide-induced antiviral protection by cytotoxic T cells
35. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C
36. The viral clearance in interferon-treated chronic hepatitis C is associated with increased cytotoxic T cell frequencies
37. Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: Potential role in chronic HCV infections