Invited review: Integration of human sleep-wake regulation and circadian rhythmicity

Journal of Applied Physiology

Volumn 92, Issue 2, 2002, Pages 852-862

  Dijk, Derk Jan ^a,b   Lockley, Steven W ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Aging; Blindness; Clock genes; Entrainment; Sleep homeostasis

Indexed keywords

AGING; ARTICLE; CIRCADIAN RHYTHM; CORRELATION ANALYSIS; ELECTROENCEPHALOGRAM; ENVIRONMENTAL FACTOR; HOMEOSTASIS; HUMAN; MOLECULAR CLOCK; MOLECULAR GENETICS; NONHUMAN; PHENOMENOLOGY; PHOTOREACTIVITY; PRIORITY JOURNAL; REGULATORY MECHANISM; SLEEP PATTERN; SLEEP WAKING CYCLE; SUPRACHIASMATIC NUCLEUS; BLINDNESS; ENVIRONMENT; GENOME; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER; PATHOPHYSIOLOGY; PHOTORECEPTOR; PHYSIOLOGY; REVIEW; SLEEP; WAKEFULNESS;

NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER;

AGING; BLINDNESS; CIRCADIAN RHYTHM; ENVIRONMENT; GENOME, HUMAN; HOMEOSTASIS; HUMANS; PHOTORECEPTORS; SLEEP; WAKEFULNESS;

EID: 0036089940     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00924.2001     Document Type: Article

References (102)

1. The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems
2. Homeostatic sleep regulation in habitual short sleepers and long sleepers
3. Dynamics of the human EEG during prolonged wakefulness: Evidence for frequency-specific circadian and homeostatic influences
4. Evidence from the waking electroencephalogram that short sleepers live under higher homeostatic sleep pressure than long sleepers
5. Circadian clock resetting by sleep deprivation without exercise in the Syrian hamster
6. Desynchronization of human circadian rhythms
7. A neural circuit for circadian regulation of arousal
8. The circadian variation of experimentally displaced sleep
9. Experimental separation of time of day and homeostatic influences on sleep
10. Individual differences in the phase and amplitude of the human circadian temperature rhythm: With an emphasis on morningness-eveningness
11. Adenosine as a biological signal mediating sleepiness following prolonged wakefulness
12. Models of human sleep regulation
13. A two process model of sleep regulation
14. Process underlying sleep regulation
15. Sleep homeostasis and models of sleep regulation
16. Endogenous sleep-promoting substances and sleep regulation
17. Action spectrum for melatonin regulation in humans: Evidence for a novel circadian photoreceptor
18. Human melatonin regulation is not mediated by the three cone photopic visual system
19. Power density in theta/alpha frequencies of the waking EEG progressively increases during sustained wakefulness
20. Frontal predominance of relative increase in sleep delta and theta EEG activity after sleep loss in humans
21. EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep loss
22. Dynamics of frontal EEG activity, sleepiness and body temperature under high and low sleep pressure
23. Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness
24. The effects of age and gender on sleep EEG power spectral density in the middle years of life (age 20-60 years old)
25. Sleep and morningness-eveningness in the "middle" years of life (20-59y)
26. Intrinsic circadian period of adolescent humans measured in conditions of forced desynchrony
27. Disruption of human circadian and cognitive regulation following a discrete hypothalamic lesion: A case study
28. Stability, precision, and near-24-hour period of the human circadian pacemaker
29. Suppression of melatonin secretion in some blind patients by exposure to bright light
30. Human sleep: Its duration and organization depend on its circadian phase
31. Influence of light on circadian rhythmicity in humans
32. Timing of human sleep: Recovery process gated by a circadian pacemaker
33. Circadian rhythms in narcolepsy: Studies on a 90 minute day
34. EEG power density during nap sleep: Reflection of an hourglass measuring the duration of prior wakefulness
35. Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG
36. Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans
37. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves and sleep spindle activity in humans
38. Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleep
39. Age-related increase in awakenings: Impaired consolidation of nonREM sleep at all circadian phases
40. Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms
41. Variation of electroencephalographic activity during nonrapid eye movement and rapid eye movement sleep with phase of circadian melatonin rhythm in humans
42. Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people
43. Later endogenous circadian temperature nadir relative to an earlier waketime in older people
44. Phase-shifting human circadian rhythms: Influence of sleep timing, social contact and light exposure
45. Association of intrinsic circadian period with morningness-eveningness, usual wake time, and circadian phase
46. Peak of circadian melatonin rhythm occurs later within the sleep of older subjects
47. Suprachiasmatic nuclei lesions eliminate circadian temperature and sleep rhythms in the rat
48. Association of structural polymorphisms in the human period 3 gene with delayed sleep phase syndrome
49. Effect of SCN lesions on sleep in squirrel monkeys: Evidence for opponent processes in sleep-wake regulation
50. Dual electroencephalogram markers of human sleep homeostasis: Correlation between theta activity in waking and slow-wave activity in sleep
51. Functional topography of the human nonREM sleep electroencephalogram
52. Circadian photoreception in the retinally degenerate mouse (rd/rd)
53. The homeostatic regulation of sleep need is under genetic control
54. Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors
55. Effects of light exposure and sleep displacement on dim light melatonin onset
56. Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans
57. A CLOCK polymorphism associated with human diurnal preference
58. Effects of aging on the intrinsic circadian period of totally blind humans
59. Inter-individual differences in the human circadian system: A review
60. Morning-type and evening-type individuals differ in the phase position of their endogenous circadian oscillator
61. Simulations of light effects on the human circadian pacemaker: Implications for assessment of intrinsic period
62. Circadian phase resetting in older people by ocular bright light exposure
63. Nonphotic entrainment of the human circadian pacemaker
64. Mathematical model of the human circadian system with two interacting oscillators
65. Sleep structure and EEG power density in morning types and evening types during a simulated day and night shift
66. A agonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects
67. Age-dependent changes in sleep EEG topography
68. Effect of age on the sleep EEG: Slow-wave activity and spindle frequency activity in young and middle-aged men
69. Melatonin: Role in gating nocturnal rise in sleep propensity
70. Relationship between melatonin rhythms and visual loss in the blind
71. Sleep and activity rhythms are related to circadian phase in the blind
72. Melatonin administration can entrain the free-running circadian system of blind subjects
73. Relationship between napping and melatonin in the blind
74. Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep
75. Retinal input to the sleep-active ventrolateral preoptic nucleus in the rat
76. Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation
77. Characterization of an ocular photopigment capable of driving pupillary constriction in mice
78. Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors
79. Clock genes outside the suprachiasmatic nucleus involved in manifestation of locomotor activity rhythm in rats
80. The hypocretin neuron system: An arousal system in the human brain
81. The circadian clock mutation alters sleep homeostasis in the mouse
82. Narcolepsy: Clinical features, new pathophysiologic insights, and future perspectives
83. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
84. A novel human opsin in the inner retina
85. Familial advanced sleep phase syndrome
86. Dynamic resetting of the human circadian pacemaker by intermittent bright light
87. Entrainment of free-running circadian rhythms by melatonin in blind people
88. A discrete lesion of ventral hypothalamus and optic chiasm that disturbed the daily temperature rhythm
89. Melatonin rhythms in delayed sleep phase syndrome
90. An action spectrum for melatonin suppression: Evidence for a novel non-rod, non-cone photoreceptor system in humans
91. The effect of sleep deprivation on sleep in rats with suprachiasmatic lesions
92. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome
93. Altered phase relation between sleep timing and core body temperature rhythm in delayed sleep phase syndrome and non-24-hour sleep-wake syndrome in humans
94. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men
95. A "clock for all seasons" in the human brain
96. Evidence for a biological dawn and dusk in the human circadian timing system
97. Dynamics of the sleep EEG after an early evening nap: Experimental data and simulations
98. Intrinsic near-24-hour pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans
99. Circadian and homeostatic control of rapid eye movement (REM) sleep: Promotion of REM tendency by the suprachiasmatic nucleus
100. Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day
101. Time zones: A comparative genetics of circadian clocks
102. Sensitivity of the human circadian pacemaker to nocturnal light: Melatonin phase resetting and suppression