Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep

Journal of Neuroscience

Volumn 20, Issue 10, 2000, Pages 3830-3842

  Lu, Jun ^a   Greco, Mary Ann ^a   Shiromani, Priyattam ^a   Saper, Clifford B ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Circadian rhythms; Hypothalamus; NREM sleep; Preoptic area; REM sleep; Thermoregulation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; AROUSAL; ARTICLE; MALE; NONHUMAN; ONCOGENE C FOS; PREOPTIC NUCLEUS; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP; THERMOREGULATION;

EID: 0034657660     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-10-03830.2000     Document Type: Article

References (25)

1. Alam MN, McGinty D, Szymusiak R (1995) Neuronal discharge of preoptic/anterior hypothalamic thermosensitive neurons: relation to NREM sleep. Am J Physiol 269:R1240-R1249.
2. Benington JH, Heller HC (1994) REM-sleep timing is controlled homeostatically by accumulation of REM-sleep propensity in non-REM sleep. Am J Physiol 266:R1992-R2000.
3. Bjorkum AA, Ha QH, Saper CB (1999) Afferents to and efferents from the raphe nuclei to the ventrolateral preoptic nucleus. Soc Neurosci Abstr 25:625.
4. Gaus SE, Saper CB (1999) Sleep-active neurons in the ventrolateral preoptic area (VLPO) are galaninergic. Soc Neurosci Abstr 25:625.
5. John J, Kumar VM (1998) The effects of NMDA lesion of the medial preoptic neurons on sleep and other functions. Sleep 21:587-598.
6. Koyama Y, Hayaishi O (1994) Firing of neurons in the preoptic/anterior hypothalamic areas in rats: its possible involvement in slow-wave sleep and paradoxical sleep. Brain Res 19:31-38.
7. Lin JS, Sakai K, Jouvet M (1988) Evidence for histaminergic arousal mechanisms in the hypothalamus of the cat. Neuropharmacology 27:111-122.
8. Lin JS, Hou Y, Sakai K, Jouvet M (1996) Histaminergic descending inputs to the mesopontine tegmentum and their role in the control of cortical activation and wakefulness in the cat. J Neurosci 16:1523-1537.
9. McGinty D, Szymusiak R, Thomson D (1994) Preoptic/anterior hypothalamic warming increases EEG delta frequency with non-rapid eye movement sleep. Brain Res 667:273-277.
10. Nauta WJH (1946) Hypothalamic regulation of sleep in rats. An experimental study. J Neurophysiol 9:285-316.
11. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. San Diego: Academic.
12. Sallanon M, Denoyer M, Kitahama K, Aubert C, Gay N, Jouvet M (1989) Long-lasting insomnia induced by preoptic neuron lesions and its transient reversal by muscimol injection into the posterior hypothalamus in the cat. Neuroscience 32:669-683.
13. Satinoff E (1978) Neural organization and evolution of thermal regulation in mammals. Science 201:16-22.
14. Scammell TE, Griffin JD, Elmquist JK, Saper CB (1998) Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever. Am J Physiol 274:R783-R789.
15. Sherin JE, Shiromani PJ, McCarley RW, Saper CB (1996) Activation of ventrolateral preoptic neurons during sleep. Science 271:216-219.
16. Sherin JE, Elmquist JK, Torrealba F, Saper CB (1998) Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat. J Neurosci 18:4705-4721.
17. Steininger TL, Stevens DR, Hass HL, McGinty D, Szymusiak D (1997) Preoptic area inhibition of histaminergic tuberomammillary neurons in vitro. Assoc Prof Sleep Soc Abstr 2.
18. Steininger TL, Alam MN, Gong H, Szymusiak R, McGinty D (1999) Sleep-waking discharge of neurons in the posterior lateral hypothalamus of the albino rat. Brain Res 840:138-147.
19. Sterman MB, Clemente CD (1962a) Forebrain inhibitory mechanisms: cortical synchronization induced by basal forebrain stimulation. Exp Neurol 6:91-102.
20. Sterman MB, Clemente CD (1962b) Forebrain inhibitory mechanisms: sleep patterns induced by basal forebrain stimulation. Exp Neurol 6:103-117.
21. Szymusiak R, McGinty D (1986) Sleep suppression following kainic acid-induced lesions of the basal forebrain. Exp Neurol 566:598-614.
22. Szymusiak R, Danowski J, McGinty D (1991) Exposure to heat restores sleep in cats with preoptic/anterior hypothalamic cell loss. Brain Res 541:134-138.
23. Szymusiak R, Alam N, Steininger TL, McGinty D (1998) Sleep-waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats. Brain Res 803:178-188.
24. von Economo C (1930) Sleep as a problem of localization. J Nerv Ment Dis 71:249-259.
25. Yang QZ, Hatton GI (1997) Excitatory and inhibitory inputs to histaminergic tuberomammillary nucleus. Brain Res 773:162-172.