Contribution of circadian physiology and sleep homeostasis to age- related changes in human sleep

Chronobiology International

Volumn 17, Issue 3, 2000, Pages 285-311

  Dijk, Derk Jan ^a   Duffy, Jeanne F ^b   Czeisler, Charles A ^b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MELATONIN;

ADULT; AGE; AGED; AROUSAL; CIRCADIAN RHYTHM; CORE TEMPERATURE; HOMEOSTASIS; HUMAN; HUMAN EXPERIMENT; LATENT PERIOD; NORMAL HUMAN; REVIEW; SLEEP; SLEEP DEPRIVATION; SLOW BRAIN WAVE; WAKEFULNESS;

NON-PROGRAMMATIC;

ADULT; AGED; BODY TEMPERATURE; CIRCADIAN RHYTHM; ELECTROENCEPHALOGRAPHY; HOMEOSTASIS; HUMANS; MELATONIN; MIDDLE AGED; PHOTOPERIOD; SLEEP; SLEEP STAGES; SLEEP, REM;

EID: 0034091497     PISSN: 07420528     EISSN: None     Source Type: Journal    
DOI: 10.1081/CBI-100101049     Document Type: Review

References (107)

1. Achermann P, Dijk D-J, Brunner DP et al. 1993. A model of human sleep homeostasis based on EEG slow-wave activity: quantitative comparison of data and simulations. Brain Res Bull. 31:97-113.
2. Ancoli-Israel S. 1997. Sleep problems in older adults: putting myths to bed. Geriatrics. 52:20-30.
3. Astrom C, Trojaborg W. 1992. Relationship of age to power spectrum analysis of EEG during sleep. J Clin Neurophysiol. 9:424-30.
4. Barrett J, Lack L, Morris M. 1993. The sleep-evoked decrease of body temperature. Sleep. 16:93-99.
5. Benington JH, Kodali SK, Heller HC. 1995. Stimulation of Al adenosine receptors mimics the electroencephalographic effects of sleep deprivation. Brain Res. 692:79-85.
6. Bina KG, Rusak B, Semba K. 1993. Localization of cholinergic neurons in the forebrain and brainstem that project to the suprachiasmatic nucleus of the hypothalamus in rat. J Comp Neurol. 335:295-307.
7. Bliwise DL. 1993. Review: sleep in normal aging and dementia. Sleep. 16:40-81.
8. Blois R, Feinberg I, Gaillard JM et al. 1983. Sleep in normal and pathological aging. Experientia. 39:551-58.
9. Boivin DB, Czeisler CA. 1998. Resetting the circadian melatonin and cortisol rhythms in humans by ordinary room light. Neuroreport. 9:779-82.
10. Boivin DB, Duffy JF, Kronauer RE et al. 1996. Dose-response relationships for resetting of human circadian clock by light. Nature. 379:540-42.
11. Bonnet MH. 1986. Effect of 64 hours of sleep deprivation upon sleep in geriatric normals and insomniacs. Neurobiol Aging. 7:89-96.
12. Borbély AA. 1982. A two process model of sleep regulation. Hum Neurobiol. 1:195-204.
13. Bowersox SS, Floyd T, Dement WC. 1984. Electroencephalogram during sleep in the cat: age effects on slow-wave activity. Sleep. 7:380-84.
14. Brainard GC, Rollag MD, Hanifin JP. 1997. Photic regulation of melatonin in humans: ocular and neural signal transduction. J Biol Rhythms. 12:537-46.
15. Buijs RM, Hermes MH, Kalsbeek A. 1998. The suprachiasmatic nucleus-paraventricular nucleus interactions: a bridge to the neuroendocrine and autonomic nervous system. Prog Brain Res. 119:365-82.
16. Buysse DJ, Monk TH, Reynolds CF III et al. 1993. Patterns of sleep episodes in young and elderly adults during a 36-hour constant routine. Sleep. 16(7):632-37.
17. Campbell SS, Terman M, Lewy AJ et al. 1995. Light treatment for sleep disorders: consensus report. V. Age-related disturbances. J Biol Rhythms. 10:151-54.
18. Carrier J, Monk TH, Buysse DJ et al. 1997. Sleep and morningness-eveningness in the "middle" years of life (20-59y). J Sleep Res. 6:230-37.
19. Carrier J, Monk TH, Reynolds CF III et al. 1999. Are age differences in sleep due to phase differences in the output of the circadian timing system? Chronobiol Int. 16: 79-91.
20. Carskadon MA, Labyak SE, Acebo C et al. 1999. Intrinsic circadian period of adolescent humans measured in conditions of forced desynchrony. Neurosci Lett. 260:129-32.
21. Czeisler CA. 1995. The effect of light on the human circadian pacemaker. In: Waterhouse JM, editor. Circadian clocks and their adjustment. Ciba Found. Symp. 183. Chichester, UK: John Wiley and Sons, pp. 254-302.
22. Czeisler CA, Allan JS, Kronauer RE. 1990. A method for assaying the effects of therapeutic agents on the period of the endogenous circadian pacemaker in man. In: Montplaisir J, Godbout R, editors. Sleep and biological rhythms: basic mechanisms and applications to psychiatry. New York: Oxford University Press, pp. 87-98.
23. Czeisler CA, Duffy JF, Shanahan TL et al. 1999. Stability, precision, and near-24-hour period of the human circadian pacemaker. Science. 284:2177-81.
24. Czeisler CA, Dumont M, Duffy JF et al. 1992. Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet. 340:933-36.
25. Czeisler CA, Klerman EB. 1999. Circadian and sleep-dependent regulation of hormone release in humans. Recent Prog Horm Res. 54:97-132.
26. Czeisler CA, Kronauer RE, Allan JS et al. 1989. Bright light induction of strong (type 0) resetting of the human circadian pacemaker. Science. 244:1328-33.
27. Czeisler CA, Wright KP Jr. 1999. Influence of light on circadian rhythmicity in humans. In: Turek FW, Zee PC, editors. Neurobiology of sleep and circadian rhythms. New York: Marcel Dekker, pp. 149-80.
28. Daan S, Beersma DGM, Borbély AA. 1984. Timing of human sleep: recovery process gated by a circadian pacemaker. Am J Physiol. 246:R161-78
29. Davis FC, Viswanathan N. 1998. Stability of circadian timing with age in Syrian hamsters. Am J Physiol. 275:R960-68.
30. Deacon S, Arendt J. 1994. Posture influences melatonin concentrations in plasma and saliva in humans. Neurosci Lett. 167:191-94.
31. DeCoursey PJ. 1986. Light-sampling behavior in photoentrainment of a rodent circadian rhythm. J Comp Physiol [A]. 159:161-69.
32. Dijk D-J. 1995. EEG slow waves and sleep spindles: windows on the sleeping brain. Behav Brain Res. 69:109-16.
33. Dijk D-J. 1997. Physiology of sleep homeostasis and its circadian regulation. In: Schwartz WJ, editor. Sleep science: integrating basic research and clinical practice. Basel, Switzerland: Karger, pp. 10-33.
34. Dijk D-J, Beersma DGM, van den Hoofdakker RH. 1989. All night spectral analysis of EEG sleep in young adult and middle-aged male subjects. Neurobiol Aging. 10: 677-82.
35. Dijk D-J, Czeisler CA. 1994. Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans. Neurosci Lett. 166: 63-68.
36. Dijk D-J, Czeisler CA. 1995. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves and sleep spindle activity in humans. J Neurosci. 15:3526-38.
37. Dijk D-J, Czeisler CA. 1998. REM sleep as a gate to wakefulness during forced desynchrony in young and older people [abstract]. Sleep. 21:S298.
38. Dijk D-J, Duffy JF, Riel E et al. 1999. Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms. J Physiol (Lond.). 516(pt. 2):611-27.
39. Dijk D-J, Edgar DM. 1999. Circadian and homeostatic control of wakefulness and sleep. In: Turek FW, Zee PC, editors. Regulation of sleep and wakefulness. New York: Marcel Dekker, pp. 111-47.
40. Dijk D-J, Kelly TK, Riel E et al. 1999. Altered homeostatic delta EEG response to sleep loss in older people? [abstract]. Sleep 22:S226.
41. Dijk D-J, Mitchell JF, Silva EJ et al. 1998. Endogenous and evoked components of the body temperature in older people during forced desynchrony of the rest-activity cycle and circadian rhythms [abstract]. Soc Res Biol Rhythms. 95.
42. Dijk D-J, Shanahan TL, Czeisler CA. 1997. Individual differences and non-additive effect of rest-activity cycle and circadian melatonin phase on core body temperature. Sleep Res. 26:709.
43. Dijk D-J, Shanahan TL, Duffy JF et al. 1997. Variation of electroencephalographic activity during non-rapid eye movement and rapid eye movement sleep with phase of circadian melatonin rhythm in humans. J Physiol (Lond.). 505(pt. 3):851-58.
44. Duffy JF. 1993. Constant routine. In: Carskadon MA, editor. Encyclopedia of sleep and dreaming. New York: Macmillan, pp. 134-36.
45. Duffy JF, Dijk D-J, Hall EF et al. 1999. Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people. J Investig Med. 47:141-50.
46. Duffy JF, Dijk D-J, Klerman EB et al. 1998. Later endogenous circadian temperature nadir relative to an earlier waketime in older people. Am J Physiol. 275:R1478-87.
47. Duffy JF, Kronauer RE, Czeisler CA. 1996. Phase-shifting human circadian rhythms: influence of sleep timing, social contact and light exposure. J Physiol (Lond.). 495: 289-97.
48. Duffy JF, Rimmer DW, Silva EJ, et al. 1999. Correlation of intrinsic period with morningness-eveningness in young men [abstract]. Sleep. 22:592.
49. Duffy JF, Viswanathan N, Davis FC. 1999. Free-running circadian period does not shorten with age in female Syrian hamsters. Neurosci Lett. 271:77-80.
50. Duffy JF, Zeitzer JM, Rimmer DW et al. 1999. Earlier circadian phase of plasma melatonin relative to usual waketime in older subjects [abstract]. Sleep Res Online. 2: 661.
51. Edgar DM, Dement WC, Fuller CA. 1993. Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. J Neurosci. 13(3):1065-79.
52. A agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans. Psychopharmacology. 130:285-91.
53. Feinberg I. 1974. Changes in sleep cycle patterns with age. J Psychiatr Res. 10:283-306.
54. Foley DJ, Monjan AA, Brown SL et al. 1995. Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep. 18:425-32.
55. Gaus SE, Saper CB. 1998. Efferent connections from the suprachiasmatic nucleus to the ventrolateral preoptic nucleus in the rat [abstract]. Soc Neurosci. 24:1920.
56. Haimov I, Lavie P. 1997. Circadian characteristics of sleep propensity function in healthy elderly: a comparison with young adults. Sleep. 20:294-300.
57. Herzog ED, Takahashi JS, Block GD. 1998. Clock controls circadian period in isolated suprachiasmatic nucleus neurons. Nature Neurosci. 1:708-13.
58. Hiddinga AE, Beersma DGM, van den Hoofdakker RH. 1997. Endogenous and exogenous components in the circadian variation of core body temperature in humans. J Sleep Res. 6:156-63.
59. Jacobs D, Ancoli-Israel S, Parker L et al. 1989. Twenty-four-hour sleep-wake patterns in a nursing home population. Psychol Aging. 4:352-56.
60. Katzenberg D, Young T, Finn L et al. 1998. A clock polymorphism associated with human diurnal preference. Sleep. 21:569-76.
61. Kelly TL, Neri DF, Grill JT et al. 1999. Nonentrained circadian rhythms of melatonin in submariners scheduled to an 18-hour day. J Biol Rhythms. 14:190-96.
62. Klerman EB, Dijk D-J, Kronauer RE et al. 1996. Simulations of effects of light on the human circadian pacemaker: implications for assessment of intrinsic period. Am J Physiol. 270:R271-82.
63. Klerman EB, Lee Y, Czeisler CA et al. 1999. Linear demasking techniques are unreliable for estimating the circadian phase of ambulatory temperature data. J Biol Rhythms. 14:260-74.
64. Klerman EB, Rimmer DW, Dijk D-J et al. 1998. Nonphotic entrainment of the human circadian pacemaker. Am J Physiol. 43:R991-96.
65. Kräuchi K, Wirz-Justice A. 1994. Circadian rhythm of heat production, heart rate, skin and core body temperature under unmasking conditions in men. Am J Physiol. 267:R819-29.
66. Kronauer RE. 1990. A quantitative model for the effects of light on the amplitude and phase of the deep circadian pacemaker, based on human data. In: Home J, editor. Sleep '90, Proceedings of the 10th European Congress on Sleep Research. Dusseldorf: Pontenagel Press, pp. 306-9.
67. Kronauer RE, Czeisler CA, Pilato SF et al. 1982. Mathematical model of the human circadian system with two interacting oscillators. Am J Physiol. 242:R3-R17.
68. Lancel M. 1999. Role of GABAA receptors in the regulation of sleep: initial sleep responses to peripherally administered modulators and antagonists. Sleep. 22:33-42.
69. Landolt H-P, Dijk D-J, Achermann P et al. 1996. Effect of age on the sleep EEG: slow-wave activity and spindle frequency activity in young and middle-aged men. Brain Res. 738:205-12.
70. Lieberman HR, Wurtman JJ, Teicher MH. 1989. Circadian rhythms of activity in healthy young and elderly humans. Neurobiol Aging. 10:259-65.
71. Liu C, Weaver DR, Strogatz SH et al. 1997. Cellular construction of a circadian clock: period determination in the suprachiasmatic nuclei. Cell. 91:855-60.
72. Lockley SW, Skene DJ, Arendt J et al. 1997. Relationship between melatonin rhythms and visual loss in the blind. J Clin Endocrinol Metab. 82:3763-70.
73. Mendelson WB, Bergmann BM. 1999. Age-related changes in sleep in the rat. Sleep. 22: 145-50.
74. Middleton B, Arendt J, Stone BM. 1996. Human circadian rhythms in constant dim light (8 lux) with knowledge of clock time. J Sleep Res. 5:69-76.
75. Miles LE, Dement WC. 1980. Sleep and aging. Sleep. 3:119-20.
76. Minors DS, Waterhouse JM, Wirz-Justice A. 1991. A human phase-response curve to light. Neurosci Lett. 133:36-40.
77. Moore RY, Silver R. 1998. Superchiasmatic nucleus organization. Chronobiol Int. 15: 475-87.
78. Myers BL, Badia P. 1995. Changes in circadian rhythms and sleep quality with aging: mechanisms and interventions. Neurosci Biobehav Rev. 19:553-71.
79. Neckelmann D, Ursin R. 1993. Sleep stages and EEG power spectrum in relation to acoustical stimulus arousal threshold in the rat. Sleep. 16:467-77.
80. Ozaki S, Uchiyama M, Shirakawa S et al. 1996. Prolonged interval from body temperature nadir to sleep offset in patients with delayed sleep phase syndrome. Sleep. 19: 36-40.
81. Pat-Horenczyk R, Klauber MR, Shochat T et al. 1998. Hourly profiles of sleep and wakefulness in severely versus mild-moderately demented nursing home patients. Aging Clin Exp Res. 10:308-15.
82. Penev P, Zee P, Turek FW. 1997. Quantitative analysis of the age-related fragmentation of hamster 24-h activity rhythms. Am J Physiol. 273:R2132-37.
83. Pittendrigh CS, Daan S. 1974. Circadian oscillations in rodents: a systematic increase of their frequency with age. Science. 186:548-50.
84. Pittendrigh CS, Daan S. 1976. A functional analysis of circadian pacemakers in nocturnal rodents. IV. Entrainment: pacemaker as clock. J Comp Physiol [A]. 106:291-331.
85. Porkka-Heiskanen T, Strecker RE, Thakkar M et al. 1997. Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science. 276:1265-68.
86. Prinz PN. 1995. Sleep and sleep disorders in older adults. J Clin Neurophysiol. 12: 139-46.
87. Reyner A, Home JA. 1995. Gender-and age-related differences in sleep determined by home-recorded sleep logs and actimetry from 400 adults. Sleep. 18:127-34.
88. Reynolds CF III, Jennings JR, Hoch CC et al. 1991. Daytime sleepiness in healthy "old old": a comparison with young adults. Am Geriatr Assoc. 39:957-62.
89. Reynolds CF III, Kupfer DJ, Hoch CC et al. 1987. Sleep deprivation as a probe in the elderly. Arch Gen Psychiatry. 44:982-90.
90. Richardson GS, Carskadon MA, Orav EJ et al. 1982. Circadian variation of sleep tendency in elderly and young adult subjects. Sleep. 5:S82-S94.
91. Sack RL, Hughes RJ, Edgar DM et al. 1997. Sleep-promoting effects of melatonin: at what dose, in whom, under what conditions, and by what mechanisms? Sleep. 20: 908-15.
92. Sack RL, Lewy AJ, Blood ML et al. 1992. Circadian rhythm abnormalities in totally blind people: incidence and clinical significance. J Clin Endocrinol Metab. 75: 127-34.
93. Satinoff E, Li H, Tcheng TK et al. 1993. Do the suprachiasmatic nuclei oscillate in old rats as they do in young ones? Am J Physiol. 265:R1216-22.
94. Sherin JE, Elmquist JK, Torrealba F et al. 1998. Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat. J Neurosci. 18:4705-21.
95. Sherin JE, Shiromani PJ, McCarley RW et al. 1996. Activation of ventrolateral preoptic neurons during sleep. Science. 271:216-19.
96. Shibui K, Uchiyama M, Okawa M. 1999. Melatonin rhythms in delayed sleep phase syndrome. J Biol Rhythms. 14:72-76.
97. Szymusiak R, Alam N, Steininger TL et al. 1998. Sleep-waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats. Brain Res. 803: 178-88.
98. Van Cauter E, Leproult R, Kupfer DJ. 1996. Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. J Clin Endocrinol Metab. 81:2468-73.
99. Van Cauter E, Plat L, Leproult R et al. 1998. Alterations of circadian rhythmicity and sleep in aging: endocrine consequences. Horm Res. 49:147-52.
100. Van Coevorden A, Mockel J, Laurent E et al. 1991. Neuroendocrine rhythms and sleep in aging men. Am J Physiol. 260:E651-61.
101. Van Someren EJW, Mirmiran M, Swaab DF. 1993. Non-pharmacological treatment of sleep and wake disturbances in aging and Alzheimer's disease: chronobiological perspectives. Behav Brain Res. 57:235-53.
102. Waterhouse J, Minors D, Folkard S et al. 1998. Light of domestic intensity produces phase shifts of the circadian oscillator in humans. Neurosci Lett. 245:97-100.
103. Webb WB. 1981. Sleep stage responses of older and younger subjects after sleep deprivation. Electroenceph Clin Neurophysiol. 52:368-71.
104. Wei HG, Riel E, Czeisler CA et al. 1999. Attenuated amplitude of circadian and sleep-dependent modulation of electroencephalographic sleep spindle characteristics in elderly human subjects. Neurosci Lett. 260:29-32.
105. Wyatt JK, Ritz-De Cecco A, Czeisler CA et al. 1999. Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day. Am J Physiol. 277:R1152-63.
106. Zeitzer, JM. 1999. Physiology and anatomy of human circadian photoreception and melatonin regulation. Dissertation. Cambridge, Massachusetts: Harvard University.
107. Zeitzer JM, Daniels JE, Duffy JF et al. 1999. Melatonin secretion: does it decline with age? Am J Med. 107:432-36.