Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain

International Journal of Neuropsychopharmacology

Volumn 5, Issue 2, 2002, Pages 131-140

  Marazziti, Donatella ^a,c   Palego, Lionella ^a   Giromella, Annalisa ^a   Mazzoni, Maria Rosa ^a   Borsini, Franco ^b   Mayer, Norbert ^b   Naccarato, Antonio Giuseppe ^a   Lucacchini, Antonio ^a   Cassano, Giovanni Battista ^a  

^a UNIVERSITY OF PISA   (Italy)

^b Boehringer Ingelheim CNS Department   (Germany)

^c Dipartimento di Informatica   (Italy)

Author keywords

5 HT1A receptors; Adenylyl cyclase activity; Buspirone; Flibanserin; Post mortem human brain

Indexed keywords

ADENYLATE CYCLASE; BUSPIRONE; FLIBANSERIN; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR;

ADULT; AGED; ARTICLE; BRAIN; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADENYLATE CYCLASE; AGED; AGED, 80 AND OVER; BENZIMIDAZOLES; BINDING, COMPETITIVE; BRAIN; BUSPIRONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FORSKOLIN; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED; PIPERAZINES; PREFRONTAL CORTEX; RAPHE NUCLEI; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0036089702     PISSN: 14611457     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1461145702002869     Document Type: Article

References (47)

1. 1A receptor. Inhibition by anxiolytic partial agonists
2. 1A receptor: Evidence for state-dependent antibody binding
3. 5-Hydroxytryptamine 2 and 5-hydroxytryptamine 1A receptors mediate opposing responses on membrane excitability in rat association cortex
4. Localised alterations in pre- and post-synaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicidal victims
5. 1A antagonists
6. 1A receptors induces rat antidepressant response
7. Current advances and trends in the treatments of depression
8. 1A receptors: Critical aspects
9. Flibanserin
10. 2A receptor antagonist, directly activates post-synaptic 5-HT inhibitory responses in the rat cerebral cortex
11. BIMT 17: A putative antidepressant with a fast onset of action?
12. 1A receptor full agonist in rat cerebral cortex
13. Lack of 5-hydroxytryptamine 1A-mediated inhibition of AC in dorsal raphe of male and female rats
14. 1A receptor sensitivity in major depression: A neuroendocrine study with buspirone
15. Anti-anhedonic actions of the novel serotonergic agent flibanserin, a potential rapidly-acting antidepressant
16. 1A receptor agonists: Recent developments and controversial issues
17. PET imaging of serotonin 1A receptor binding in depression
18. In vivo electrophysiological characterization of 5-HT receptors in the guinea pig head of caudate nuclei and orbitofrontal cortex
19. 1A) receptors in human post-mortem brain
20. Serotonin 1A receptor agonists as antidepressants
21. Assay of AC catalytic activity
22. Isolation and characterization of S49 lymphoma cells deficient in beta-adrenergic receptors: Relation of receptor number to activation of adenylate cyclase
23. 3H]8-OH-DPAT labels a 5-HT site coupled to inhibition of phosphoinositide hydrolyis in the dorsal raphe
24. Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity
25. 1A receptor function in normal subjects on clinical doses of fluoxetine: Blunted temperature and hormone responses to ipsapirone challenge
26. 1A receptor sensitivity in depression and anxiety disorders: Molecular mechanisms of neuroadaption
27. 1A receptor
28. Augmentation of standard depression therapy
29. 1A) receptors in human brain post-mortem
30. Effects of ipsapirone on plasma cortisol and body temperature in major depression
31. 3H]8-OH-DPAT binding sites in rat cerebral cortex and hippocampus
32. Serotonin inhibition of adenylate cyclase in human platelet membranes: Relation to 5-HT1A receptor-mediated activity
33. 1A 5-hydroxytryptamine receptors in Chinese hamster ovary cells
34. Preservation of 5-hydroxytryptamine 1A receptor G protein interactions in the cerebral cortex of patients with Alzheimer disease
35. Effects of post-mortem delay on serotonin and (±)8-OH-DPAT-mediated inhibition of AC activity in rat and human brain tissues
36. 3H]8-hydroxy-2 (di-N-propylamino)tetraline binding sites in human brain post-mortem
37. A simplification of the protein assay method which is more generally applicable
38. 1A receptors in the rat brain
39. Adenylate cyclase assay
40. 11C]WAY-100635: Effects of depression and antidepressant treatment
41. 1A receptor ligands in animal models of anxiety, impulsivity and depression: Multiple mechanisms
42. Blunted temperature and cortisol responses to ipsapirone in major depression: Lack of enhancement by electroconvulsive therapy
43. 1A receptor activated G-proteins in rat brain following chronic buspirone
44. Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with depression - Postmortem evidence for decreased serotonin activity
45. Anxiolytic 5-hydroxytryptamine1A agonists suppress firing activity of dorsal hippocampus CA1 pyramidal neurons through a postsynaptic mechanism: Single-unit study in unanesthetized, unrestrained rats
46. Lack of apparent reserve at post-synaptic 5-hydroxytryptamine1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes
47. How long should pindolol be associated with paroxetine to improve the antidepressant response?