Anxiolytic 5-hydroxytryptamine(1A) agonists suppress firing activity of dorsal hippocampus CA1 pyramidal neurons through a postsynaptic mechanism: Single-unit study in unanesthetized, unrestrained rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 2, 1999, Pages 843-848

  Tada, Koji ^a,b   Kasamo, Kimihiro ^a   Ueda, Naoki ^a   Suzuki, Tadashi ^a   Kojima, Takuya ^a   Ishikawa, Koichi ^a  

^a NIHON UNIVERSITY   (Japan)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 2 DIBUTYLAMINO 8 HYDROXYTETRALIN; ANXIOLYTIC AGENT; BUSPIRONE; FENCLONINE; FLESINOXAN; IPSAPIRONE; PINDOLOL; POSTSYNAPTIC RECEPTOR; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; 1 (2 METHOXYPHENYL) 4 (4 (2 PHTHALIMIDO)BUTYL)PIPERAZINE; 1-(2-METHOXYPHENYL)-4-(4-(2-PHTHALIMIDO)BUTYL)PIPERAZINE; PIPERAZINE DERIVATIVE; SEROTONIN 1 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEAR; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SINGLE UNIT ACTIVITY; TRANQUILIZING ACTIVITY; ANIMAL; DRUG EFFECT; DRUG INTERACTION; NERVE CELL; PHYSIOLOGY; ULTRASTRUCTURE; WISTAR RAT;

ANIMALS; ANTI-ANXIETY AGENTS; BUSPIRONE; DRUG INTERACTIONS; MALE; NEURONS; PINDOLOL; PIPERAZINES; PYRAMIDAL CELLS; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0032590066     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Andrade R and Nicoll RA (1987) Pharmacologically distinct actions of serotonin on single pyramidal neurons of the rat hippocampus recorded in vitro. J Physiol (Lond) 394:99-124.
2. 1A antagonists. Trends Neurosci 19:378-383.
3. Blier P and de Montigny C (1987) Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: Electrophysiological studies in the rat brain. Synapse 1:470-480.
4. Blier P and de Montigny C (1990) Differential effect of gepirone on presynaptic and postsynaptic serotonin receptors: Single-cell recording studies. J Clin Psychopharmacol 10 (Suppl 3):13S-20S.
5. Buzsaki G, Leung L-WS and Vanderwolf CH (1983) Cellular bases of hippocampal EEG in the behaving rat. Brain Res Rev 6:139-171.
6. Cassia S, Conti I, Vagano C and Garattini S (1986) 1-(2-Pirimidynil)-piperazine as active metabolite of buspirone in man and rat. Pharmacology 33:46-51.
7. 1A receptor antagonist NAN-190 on rat brain serotonergic transmission. Eur J Pharmacol 204:71-77.
8. 1A agonist and antagonist drug administration in behaving cats. J Pharmacol Exp Ther 270:1345-1358.
9. Fornal CA, Marrosu F, Metzler CW, Tada K and Jacobs BL (1994b) Effects of the putative 5-hydroxytryptamine1A antagonists BMY 7378, NAN 190 and (-)-propranolol on serotonergic dorsal raphe unit activity in behaving cats. J Pharmacol Exp Ther 270:1359-1366.
10. Fornal CA, Metzler CW, Gallegos RA, Veasey SC, McCreary AC and Jacobs BL (1996) WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: Comparison with (S)-WAY-100135. J Pharmacol Exp Ther 278:752-762.
11. Fox SE and Ranck JB Jr (1975) Location and anatomical identification of theta and complex-spike cells in dorsal hippocampal formation of rats. Exp Neurol 49:299-313.
12. Freund TF and Buzsaki G (1996) Interneurons of the hippocampus. Hippocampus 6:347-470.
13. 1A receptors, in Serotonin 1A Receptors in Depression and Anxiety (Stahl SM, Gastpar M, Keppel Hesselink JM and Traber J eds) pp. 35-53, Raven Press, New York.
14. 1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat raphe nucleus in vitro. Eur J Pharmacol 211:211-219.
15. Hadrava V, Blier P, Dennis T, Ortemann C and de Montigny C (1995) Characterization of 5-hydroxytryptamine1A properties of flesinoxan: In vivo electrophysiology and hypothermia study. Neuropharmacology 34:1311-1326.
16. Hjorth S and Sharp T (1990) Mixed agonist/antagonist properties of NAN-190 at 5-HT1A receptors: Behavioral and in vivo brain microdialysis studies. Life Sci 46:955-963.
17. Heym J, Steinfels GF and Jacobs BL (1984) Chloral hydrate anesthesia alters the responsiveness of central serotonergic neurons in the cat. Brain Res 291:63-72.
18. Inoue T, Tsuchiya K and Koyama T (1996) Serotonergic activation reduces defensive freezing in the conditioned fear paradigm. Pharmacol Biochem Behav 53:825-831.
19. Jacobs BL (1985) An overview of brain serotonergic unit activity and its relevance to the neuropharmacology of serotonin, in Neuropharmacology of Serotonin (Green AR ed) pp 196-217, Oxford University Press, Oxford.
20. 1A agonists on hippocampal rhythmical slow activity in unanesthetized rats. Neuropharmacology 33:905-914.
21. Kim JJ and Fanselow MS (1992) Modality-specific retrograde amnesia of fear. Science (Wash DC) 256:675-677.
22. Koe BK and Weissman A (1966) p-Chlorophenylalanine: A specific depletor of brain serotonin. J Pharmacol Exp Ther 154:499-516.
23. Kosofsky BE and Molliver ME (1987) The serotoninergic innervation of cerebral cortex: Different classes of axon terminals arise from dorsal and medial raphe nuclei. Synapse 1:153-168.
24. Lidov HG, Grzanna R and Molliver ME (1980) The serotonin innervation of the cerebral cortex in the rat - An immunohistochemical analysis. Neuroscience 5:207-227.
25. Meller E, Goldstein M and Bohmaker K (1990) Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: Possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists. Mol Pharmacol 37:231-237.
26. 1A receptor-mediated activity in the rat: A pharmacological characterization of the actions of novel agonists and antagonists. J Pharmacol Exp Ther 264:1364-1376.
27. Millan MJ, Hjorth S, Samanin R, Schreiber R, Jaffard R, De Ladonchamps B, Veiga S, Goument B, Peglion J-L, Spedding M and Brocco M (1997) S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: II. Modulation of hippocampal serotonin release in relation to potential anxiolytic properties. J Pharmacol Exp Ther 282:148-161.
28. O'Keefe J and Dostrovsky J (1971) The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res 34:171-175.
29. Pazos A and Palacios JM (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I-Serotonin-1 receptors. Brain Res 346:205-230.
30. Phillips RG and LeDoux JE (1992) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106:274-285.
31. Przegalinski E, Tatarczynska E, Klodzinska A and Chojnacka-wojcik E (1994) The role of postsynaptic 5-HT1A receptors in the anticonflict effect of ipsapirone. Neuropharmacology 33:1109-1115.
32. 1A agonist, in three stress paradigms: Immobilization, forced swim and conditioned fear. Brain Res 580:205-214.
33. Robinson DS, Shrotriya RC, Alms DR, Messina M and Andary J (1989) Treatment of panic disorder: Nonbenzodiazepine anxiolytics, including buspirone. Psychopharmacol Bull 25:21-26.
34. 1A receptor ligands by means of in vivo animal models. Eur J Pharmacol 315:245-254.
35. Schipper J, Tulp M Th M, Berkelmans B, Mos J, Van der Heijden JAM and Oliver B (1991) Preclinical pharmacology of flesinoxan: A potential anxiolytic and antidepressant drug. Hum Psychopharmacol 6:S53-S61.
36. Sharp T, Bramwell S and Graham-Smith DG (1989) 5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. Br J Pharmacol 96:283-290.
37. Sprouse JS and Aghajanian GK (1988) Response of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: A comparative study with dorsal raphe neurons. Neuropharmacology 27:707-715.
38. Suzuki SS and Smith GK (1985) Single-cell activity and synchronous bursting in the rat hippocampus during waking behavior and sleep. Exp Neural 89:71-89.
39. Tork I (1990) Anatomy of the serotonergic system. Ann NY Acad Sci 600:9-34.
40. 1A Agonists, 5-HT3 Antagonists and Benzodiazepines: Their Comparative Behavioral Pharmacology (Rodgers RJ and Cooper SJ eds) pp 107-131, John Wiley & Sons, West Sussex.
41. Verge D, Daval G, Patey A, Gozlan A, EL Mestikawy S and Hamon M (1985) Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype. Eur J Pharmacol 113:463-464.
42. 1A binding sites on serotonin-containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain. Neurochemistry 7:1061-1072.
43. Yocca FD, Iben L and Meller E (1992) Lack of apparent receptor reserve at postsynaptic 5-hydroxytryptamine1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampla membranes. Mol Pharmacol 41:1066-1072.