Anti-anhedonic actions of the novel serotonergic agent flibanserin, a potential rapidly-acting antidepressant

European Journal of Pharmacology

Volumn 340, Issue 2-3, 1997, Pages 121-132

  D'Aquila, Paolo ^a   Monleon, Santiago ^b   Borsini, Franco ^c   Brain, Paul ^a   Willner, Paul ^a  

^a SWANSEA UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF VALENCIA   (Spain)

^c Boehringer Ingelheim Italia SpA   (Italy)

Author keywords

Anhedonia; Flibanserin; Fluoxetine; Locomotor activity; Mouse; Place preference conditioning; Quinpirole; Raclopride; Rat; Reward; Stress; Sucrose drinking

Indexed keywords

FLIBANSERIN; FLUOXETINE; QUINPIROLE; SEROTONIN AGONIST; UNCLASSIFIED DRUG;

ANHEDONIA; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONDITIONING; CONTROLLED STUDY; FOOD INTAKE; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; LONG TERM EXPOSURE; MALE; NONHUMAN; PLACE PREFERENCE; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BENZIMIDAZOLES; BODY WEIGHT; CONDITIONING, OPERANT; DOPAMINE ANTAGONISTS; FEEDING BEHAVIOR; MALE; MICE; MOTOR ACTIVITY; QUINPIROLE; RACLOPRIDE; RATS; RATS, WISTAR; SALICYLAMIDES; SEROTONIN AGENTS; STRESS, PSYCHOLOGICAL; SUCROSE;

EID: 0031565116     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01412-X     Document Type: Article

References (57)

1. American Psychiatric Association (1980) DSM III - Diagnostic and Statistical Manual of Psychiatric Disorders, 3rd Edition. American Psychiatric Association, Washington D.C.
2. American Psychiatric Association (1987) DSM IIIR - Diagnostic and Statistical Manual of Psychiatric Disorders, 3rd Edition (Revised). American Psychiatric Association, Washington D.C.
3. Amsterdam J.D. Gepirone, a selective serotonin (5HT(1A)) partial agonist in the treatment of major depression. Prog. Neuro-Psychopharmaol. Biol. Psychiatr. 16:1992;271-280.
4. Anisman H., Zacharko R.M. Depression: The predisposing influence of stress. Behav.Brain Sci. 5:1982;89-137.
5. Arnt J., Hytell J., Overo K.F. Prolonged treatment with the specific 5-HT uptake inhibitor citalopram: Effect on dopaminergic and serotonergic functions. Pol. J. Pharm. Pharmacol. 36:1984;221-230.
6. Asberg M., Eriksson B., Martensson B., Traskman-Bendz L., Wagner A. Therapeutic effects of serotonin uptake inhibitors in depression. J. Clin. Psychiatr. 47 (Suppl.)(4):1986;23-35.
7. Blundell J.E. Serotonin manipulations and the structure of feeding behaviour. Appetite. 7 (Suppl.):1986;39-56.
8. 1A receptor full agonist in rat cerebral cortex. Naunyn Schmiedeberg's Arch. Pharmacol. 352:1995;276-282.
9. 2A receptor antagonist, directly activates postsynaptic 5-HT inhibitory responses in the rat cerebral cortex. Naunyn Schmiedeberg's Arch. Pharmacol. 352:1995;283-290.
10. Borsini, F., Cesana, R., Kelly, J., Leonard, B.E., McNamara, M., Richards, J., Seiden, L., 1997. BIMT 17: A putative antidepressant with a fast onset of action? Psychopharmacology, in press.
11. Bremner J.D. Fluoxetine in depressed patients: A comparison with imipramine. J. Clin. Psychiatr. 45:1986;414-419.
12. Brown, G.W., Harris, T. (Eds.), 1988. Life Events and Illness. Guilford Press, New York.
13. Cesana R., Ciprandi C., Borsini F. The effect of BIMT 17, a new potential antidepressant, in the forced swimming test in mice. Behav. Pharmacol. 6:1995;688-694.
14. Cheeta S., Broekkamp C., Willner P. Reversal of stress-induced anhedonia by mianserin and its (+)-enantiomer. Psychopharmacology. 116:1994;523-528.
15. D'Aquila P., Brain P.F., Willner P. Effects of chronic mild stress in behavioural tests relevant to anxiety and depression. Physiol. Behav. 56:1994;861-867.
16. Fawcett J., Clark D.C., Scheftner W.A., Gibbons R.D. Assessing anhedonia in psychiatric patients: The pleasure scale. Arch. Gen. Psychiatr. 40:1983;79-84.
17. Festing M.F.W. Reduction of animal use: Experimental design and quality of experiments. Lab. Animals. 28:1994;212-221.
18. Forbes N.F., Stewart C.A., Matthew K., Reid I.C. Chronic mild stress and sucrose consumption: Validity as a model of depression. Physiol Behav. 60:1996;1481-1484.
19. Fuller R.W., Hemrick-Luecke S.K. Decrease in hypothalamic epinephrine concentration and other neurochemical changes produced by quinpirole, a dopamine agonist, in rats. J. Neural Transm. 61:1985;161-173.
20. Hatcher J.P., Bell D.J., Hagan J.J. CMS induced reductions in saccharin intake depend upon nutritive state. J. Psychopharmacol. 10 (Suppl.):1996;A27.
21. Kanner A.D., Coyne J.C., Schaefer C., Lazarus R.S. Comparison of two modes of stress measurement: Daily hassles and uplifts versus major life events. J. Behav. Med. 4:1981;1-39.
22. Klein D.F. Endogenomorphic depression: A conceptual and terminological revision. Arch. Gen. Psychiatr. 31:1974;447-454.
23. Lloyd C. Life events and depressive disorders reviewed. 2. Events as precipitating factors. Arch. Gen. Psychiatr. 37:1980;541-548.
24. Maj, J., 1988. Repeated treatment with antidepressant drugs and functional changes of catecholaminergic receptors at the behavioural level. In: Belmaker, R.H., Sandler, M., Dahlstrom, A. (Eds.), Progress in Catecholamine Research: Part C, Clinical Aspects. Liss, New York, pp. 255-261.
25. Maj J., Wedzony K. Repeated treatment with imipramine or amitriptyline increases the locomotor response of rats to (+)-amphetamine given into the nucleus accumbens. J. Pharm. Pharmacol. 37:1985;362-364.
26. Maj J., Wedzony K. The influence of oxaprotaline enantiomers given repeatedly on the behavioural effects of D-amphetamine and dopamine injected into the nucleus accumbens. Eur. J. Pharmacol. 145:1988;97-103.
27. Maj J., Rogoz Z., Skuza G., Sowinska H. Repeated treatment with antidepressant drugs potentiates the locomotor response to (+)-amphetamine. J. Pharm. Pharmacol. 36:1984;127-130.
28. Maj J., Rogoz Z., Skuza G., Sowinska H. Repeated treatment with antidepressant drugs increases the behavioural response to apomorphine. J. Neural Transm. 60:1984;273-282.
29. Maj J., Wedzony K., Klimek V. Desipramine given repeatedly enhances behavioural effects of dopamine and D-amphetamine injected into the nucleus accumbens. Eur. J. Pharmacol. 140:1987;179-185.
30. Martin-Iverson M., Leclere J.F., Fibiger H.C. Cholinergic-dopaminergic interactions and the mechanisms of action of antidepressants. Eur. J. Pharmacol. 94:1983;193-201.
31. Matthews K., Forbes N., Reid I.C. Sucrose consumption as a hedonic measure following chronic unpredictable mild stress. Physiol. Behav. 57:1995;241-248.
32. McGuirk J., Muscat R., Willner P. Effects of chronically administered fluoxetine and fenfluramine on food intake, body weight, and the behavioural satiety sequence. Psychopharmacology. 106:1992;401-407.
33. Monleon S., D'Aquila P., Parra A., Simon V.M., Brain P.F., Willner P. Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine. Psychopharmacology. 117:1994;453-457.
34. Moreau J.-L., Jenck F., Martin J.R., Mortas P., Haefely W.E. Antidepressant treatment prevents chronic mild stress-induced anhedonia as assessed by ventral tegmentum self-stimulation behaviour in rats. Eur. Neuropsychopharmacol. 2:1992;43-49.
35. Moreau J.-L., Jenck F., Martin J.R., Mortas P., Haefely W.E. Effects of moclobemide, a new generation reversible MAO-A inhibitor, in a novel animal model of depression. Pharmacopsychiatry. 26:1993;30-33.
36. Moreau J.-L., Jenck F., Martin J.R., Mortas P. Curative effects of the atypical antidepressant mianserin in the chronic mild stress-induced anhedonia model of depression. J. Psychiatr. Neurosci. 19:1994;51-56.
37. Morley J.E., Flood J.F. An investigation of tolerance to the actions of leptogenic and anorexigenic drugs in mice. Life Sci. 41:1987;2157-2165.
38. Muscat R., Sampson D., Willner P. Dopaminergic mechanism of imipramine action in an animal model of depression. Biol. Psychiatr. 28:1990;223-230.
39. Muscat R., Papp M., Willner P. Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline. Psychopharmacology. 109:1992;433-438.
40. Nelson J.C., Charney D.S. The symptoms of major depression. Am. J. Psychiatr. 138:1981;1-13.
41. Papp M., Willner P., Muscat R. An animal model of anhedonia. Attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress. Psychopharmacology. 104:1991;255-259.
42. Papp M., Lappas S., Muscat R., Willner P. Attenuation of place preference conditioning but not place aversion conditioning by chronic mild stress. J. Psychopharmacol. 6:1992;352-356.
43. Papp M., Muscat R., Willner P. Subsensitivity to rewarding and locomotor stimulant effects of a dopamine agonist following chronic mild stress. Psychopharmacology. 110:1993;152-158.
44. Papp M., Muscat R., Willner P. Behavioural sensitization to a dopamine agonist is associated with recovery from stress-induced anhedonia. Psychopharmacology. 110:1993;159-164.
45. 2 receptor binding in limbic forebrain associated with chronic mild stress-induced anhedonia and its reversal by imipramine. Psychopharmacology. 115:1994;441-446.
46. Papp M., Moryl E., Willner P. Pharmacological validation of the chronic mild stress model of depression. Eur. J. Pharmacol. 296:1996;129-136.
47. Phillips G., Willner P., Muscat R. Reward-dependent suppression or facilitation of consummatory behaviour by raclopride. Psychopharmacology. 105:1991;355-360.
48. Sampson D., Muscat R., Willner P. Reversal of antidepressant action by dopamine antagonists in an animal model of depression. Psychopharmacology. 104:1991;491-495.
49. 3) as a target for neuroleptics. Nature. 347:1990;146-151.
50. Willner, P., 1997. Validity, reliability and utility of the chronic mild stress (CMS) model of depression: A ten-year evaluation and review. Psychopharmacology, pp. 213-234.
51. Willner P., Montgomery A. Behavioural changes during withdrawal from the tricyclic antidepressant desmethylimipramine (DMI). I. Interactions with amphetamine. Psychopharmacology. 75:1981;54-59.
52. Willner, P., Papp, M., 1997. Animal models to detect antidepressants: Are new strategies necessary to detect new agents? In: Skolnick, P. (Ed.), Antidepressants: Current Trends and Future Directions. Humana, NJ, pp. 213-234.
53. Willner P., Towell A., Sampson D., Muscat R., Sophokleous S. Reduction of sucrose preference by chronic mild stress and its restoration by a tricyclic antidepressant. Psychopharmacology. 93:1987;358-364.
54. Willner P., Muscat R., Papp M. Chronic mild stress-induced anhedonia: A realistic animal model of depression. Neurosci. Biobehav. Rev. 16:1992;525-534.
55. Willner P., Lappas S., Cheeta S., Muscat R. Reversal of stress-induced anhedonia by the dopamine agonist, pramipexole. Psychopharmacology. 115:1994;454-462.
56. Willner P., Moreau J.-M., Nielsen C., Papp M., Sluzewska A. Decreased hedonic responsiveness following chronic mild stress is not secondary to loss of body weight. Physiol. Behav. 60:1996;129-134.
57. Winer, B.J. (1971) Statistical Principles in Experimental Design. McGraw Hill, London.