Further characterisation of [3H]8-hydroxy-2-(di-N-propylamino)tetralin binding sites in human brain postmortem

Neurochemistry International

Volumn 30, Issue 2, 1997, Pages 149-157

  Palego, Lionella ^a   Marazziti, Donatella ^a   Rotondo, Alessandro ^a   Batistini, Alfredo ^a   Lucacchini, Antonio ^a   Naccarato, Antonio G ^a   Bevilacqua, Generoso ^a   Borsini, Franco ^b   Ladinsky, Herbert ^b   Cassano, Giovanni B ^a  

^a UNIVERSITY OF PISA   (Italy)

^b Boeringher Ingelheim Italia ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; DIVALENT CATION; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MAGNESIUM ION; MANGANESE; NUCLEOTIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN AGONIST;

ADULT; AGED; ARTICLE; AUTOPSY; BINDING SITE; BRAIN; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; ANALYSIS OF VARIANCE; BINDING COMPETITION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; KINETICS; MEMBRANE; METABOLISM; MIDDLE AGED; RADIOASSAY;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BINDING SITES; BINDING, COMPETITIVE; CATIONS, DIVALENT; CEREBRAL CORTEX; CORPUS STRIATUM; FEMALE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HIPPOCAMPUS; HUMANS; KINETICS; MALE; MEMBRANES; MIDDLE AGED; RADIOLIGAND ASSAY; SEROTONIN AGONISTS;

EID: 0030614880     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(96)00050-2     Document Type: Article

References (33)

1. Albert, P. R., Zhou, Q. Y., Van Tol, H. H. M., Bunzow, J. R. and Civelli, O. (1990) Cloning, functional expression and mRNA tissue distribution of the rat 5-hydroxytryptamine 1A receptor gene. J. Biol. Chem. 265, 5825-5832.
2. 3H8-OH-DPAT labels the 5-hydroxytryptamine uptake recognition site and the 5HT1A binding site in the rat striatum. J. Pharm. Pharmacol. 40, 888-891.
3. 3H-paroxetine binding to serotonin uptake sites in human brain tissues. I characteristics . Brain Res. 486, 261-269.
4. 3H-imipramine binding of protein nature in the human brain. Brain Res. 425, 128-136.
5. Bohmaker, K., Bordi, F. and Meller, E. (1992) The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve. Neuropharmacology 31, 451-459.
6. Cheetham, S. C., Crompton, M. R., Katona, C. L. E. and Horton, R. W. (1990) Brain 5-HT1 binding sites in depressed suicides. Psychopharmacol. 102, 544-548.
7. De Montigny, C., Chaput, Y. and Blier, P. (1993) Classical and novel targets for antidepressant drugs. In New Pharmacology Approach to the Terapy of Depressive Disorders, Mendlewicz, J., Brunello, N., Langer, S. Z., Racagni, G., ed., pp. 8-17. Karger Press, Basel.
8. Dillon, K. A., Gross-Isseroff, R, Israeli, M. and Biegon, A. (1991) Autoradiographic analysis of serotonin IA receptor binding in the human brain postmortem: effects of age and alcohol. Brain Res. 554, 56-64.
9. 1A receptor. J. Neurochem. 56, 1705-1716.
10. Fargin, A., Raymond, J. R., Regan, J. V., Cotecchia, S., Lefkowitz, R. J. and Caron, M. G. (1989) Effector coupling mechanism of the cloned 5-HT1A receptor. J. biol. Chem. 2645, 14848-14852.
11. 3H]PAT. Nature 305, 140-142.
12. 3H]8-hydroxy-2-(di-N-propylamino)tetralin binding to pre-and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain. J. Neurochem. 44, 1685-1696.
13. Hall, M. D., Gozlan, H., Emerit, M. B., El Mestikawy, S., Pichat, L. and Hamon, M. (1986) Differentiation of pre-and postsynaptic high affinity serotonin receptor binding sites using psychochemical parameters and modifying agents. Neurochem. Res. 11, 891-912.
14. Hamon, M., Bourgoin, S., Gozlan, H., Hall, M. D., Goetz, C., Artaud, F. and Horn, A. S. (1984) Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-N-propylamino)tetralin) in the rat brain. Eur. J. Pharmacol. 100, 263-276.
15. Hashimoto, T., Nishino, N., Nakai, H. and Tanaka, C. (1991) Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia. Life Sci. 48, 355-363.
16. Hover, D., Pazos, A., Probst, A. and Palacios, J. M. (1986) Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain Res. 376, 85-96.
17. Ieni, J. R. and Meyerson, L. R. (1988) The 5-HT1A receptor probe [3H]8-OH-DPAT labels the 5-HT transporter in human platelets. Life Sci. 42, 311-320.
18. Kobilka, B. K., Frielle, T., Collins, S., Yang-Feng, T., Kobilka, T. S., Francek, U., Lefkowitz, R. J. and Caron, M. G. (1987) An intron-less gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature 329, 75-79.
19. Lovenberg, T. W., Erlander, M. G., Baron, B. M. and Sutcliffe, J. G. (1993) Cloning of new 5-HT receptors. Int. Clin. Psychopharmacol. 8(S2), 19-23.
20. Marazziti, D., Marracci, S., Palego, L., Rotondo, A., Mazzanti, C., Nardi, I., Ladinsky, H., Giraldo, E., Borsini, F. and Cassano, G. B. (1994) Localization and gene expression of serotonin 1A (5-HT1A) receptors in human brain postmortem. Brain Res. 658, 55-59.
21. McPherson, G. A. (1985) KINETIC, EBDA, LIGAND, LOWRY: A Collection of Radio Ligand Binding Analysis Programs. Biosoft, Cambridge, U.K.
22. Middlemiss, D. N., Palmer, A. N., Edel, N. and Bowen, D. W. (1986) Binding of the novel serotonin agonist 8-hydroxy-2-(di-N-propylamino)tetralin in normal and Alzheimer brain. J. Neurochem. 46, 993-996.
23. Mongeau, R., Welner, S. A., Quirion, R. and Suranyi-Cadotte, B. E. (1992) Further evidences for differential affinity states of the serotonin IA receptor in rat hippocampus. Brain Res. 590, 229-238.
24. O'Neill, C., Cowbum, R. F., Wiehager, B., Alafuzoff, I., Windbland, B. and Fowler, C. J. (1991) Preservation of 5-hydroxytryptamine-1A receptor-Gprotein interactions in the cerebral cortex of patients with Alzheimer's disease. Neurosci. Lett. 133, 15-19.
25. Pazos, A., Probst, A. and Palacios, A. M. (1987) Serotonin receptors in the human brain. III. Autoradiographic mapping of 5-HT1 receptors. Neuroscience 21, 97-122.
26. Peroutka, S. J. (1986) Pharmacological differentiation and characterization of 5-HT1A , 5-HT1B and 5-HT1C binding sites in rat frontal cortex. J. Neurochem. 47, 529-540.
27. Peterson, G. L. (1977) A simplification of the protein assay method which is more generally applicable. Anal. Biochem. 83, 356-366.
28. 3H]8-OH-DPAT labels the serotonin transporter in the rat striatum. Eur. J. Pharmacol. 124, 371-373.
29. Schreiber, R. and De Vry, J. (1993) 5-HT1A receptor ligands in animal models of anxiety, impulsivity and depression: multiple mechanisms. Progr. Neuropsychopharmacol. Biol. Psychiatry 17(1), 87-104.
30. 3H]8-OH-DPAT lebeling of serotonin uptake sites. Brain Res. 617, 159-162.
31. Stam, N. J., Van Huizen, F., Van Alebeek, C., Brands, J., Dijkema, R., Tonnaer, J. A. D.M. and Olije, W. (1992) Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes. Eur. J. Pharmacol. 227, 153-162.
32. Vergé, D., Daval, G., Marcinkiewicz, M., Patey, A., El Mestikawy, S., Gozlan, H. and Hamon, M. (1986) Quantitative autoradiography of multiple 5HT1 receptor subtypes in the brain of control and 5,7-DHT treated rats. J. Neurosci. 6, 3474-3482.
33. Waeber, C., Dietl, M. M., Hoyer, D. and Palacios, J. M. (1989) 5HT1 receptors in the vertebrate brain. Regional distribution examined by autoradiography. Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 486-494.