Effect of pre-treatment with dichloroacetic or trichloroacetic acid in drinking water on the pharmacokinetics of a subsequent challenge dose in B6C3F1 mice

Chemico-Biological Interactions

Volumn 123, Issue 3, 1999, Pages 239-253

  Gonzalez Leon, Alberto ^a   Merdink, James L ^a   Bull, Richard J ^b   Schultz, Irvin R ^b  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

Dichloroacetic or trichloroacetic acid; Drinking water; Pre treatment

Indexed keywords

DICHLOROACETIC ACID; DRINKING WATER; TRICHLOROACETIC ACID;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHLORINATION; CONTROLLED STUDY; DRUG METABOLISM; GAS CHROMATOGRAPHY; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PHARMACOKINETICS; RAT; SPECIES DIFFERENCE; WATER TREATMENT;

ANIMALS; CARBON RADIOISOTOPES; CHROMATOGRAPHY, GAS; DICHLOROACETATE; MALE; MICE; RATS; TRICHLOROACETIC ACID; WATER SUPPLY;

EID: 0032715173     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(99)00140-4     Document Type: Article

References (21)

1. P.C. Singer, Disinfection by-products: From source to tap, in: Disinfection by products in Drinking Water: Critical Issues in Health Effects Research. Workshop Report. International Life Science Institute Health and Environmental Sciences Institute, 1995.
2. Westrick J.J., Mello J.W., Thomas R.F. The ground water supply survey. J. Am. Water Works Assoc. 75:1984;52.
3. National Cancer Institute. Carcinogenesis bioassay of trichloroethylene. CAS No. 79-01-6. DHEW. Pub. No. (NIH) 76-802, 1976.
4. Maltoni C., Lefemine G., Cotti G. Experimental research on trichloroethylene carcinogenesis. Maltoni C., Mehlman M.A. Archives of Research on Industrial Carcinogenesis. 1986;Princeton Scientific, Princeton, NJ.
5. National Toxicology Program. Toxicology and carcinogenesis studies of trichloroethylene in four strains of rats. CAS No. 79-01-6, NTPTR 273. Research Triangle Park, NC. U.S. Department of Health and Human Services, Public Health Services, National Institute of Health, 1988.
6. National Toxicology Program. Draft technical report on the toxicology and carcinogenesis studies of chlorinated and chloraminated water in F344/N rats and B6C3F1 mice. Research Triangle Park, NC, 1990.
7. Bull R.J., Sanchez I.M., Nelson M.A., Larson J.L., Lansing A.J. Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate. Toxicology. 63:1990;341-359.
8. DeAngelo A.B., Daniel F.B., Stober A.J., Olson G.R. The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse. Fund. Appl. Toxicol. 16:1991;337-347.
9. Herren-Freund S.L., Pereira M.A., Khoury M.D., Olsen G. The carcinogenicity of trichloroethylene and its metabolises, trichloroacetic and dichloroacetic acid, in mouse liver. Toxicol. Appl. Pharmacol. 90:1987;183-189.
10. Curry S.H., Lorenz A., Chu P., Limacher M., Stacpoole P.W. Disposition and pharmacodynamics of dichloroacetate (DCA) and oxalate following oral DCA doses. Biopharm. Drug Dis. 12:1991;375-390.
11. Lipscomb J.C., Mahale D.A., Brashear W.T., Barton H.A. Dichloroacetic acid: Metabolism in the cytosol. Drug Metab. Dis. 23:1995;1203-1205.
12. Gonzalez-Leon A., Schultz I.R., Xu G., Bull J.R. Pharmacokinetics and metabolism of dichloroacetate in the F344 rat after prior administration in drinking water. Toxicol. Appl. Pharmacol. 146:1997;189-195.
13. James M.O., Cornett R., Yan Z., Henderson G.N., Stacpoole P.W. Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats. Drug Metab. Dis. 25:1997;1223-1227.
14. Green T, Prout M.S. Species differences in response to trichloroethylene. II. Biotransformation in rats and mice. Toxicol. Appl. Pharmacol. 79:1985;401-411.
15. Fisher J.W., Whittaker T.A., Taylor D.H., Clewell III H.J., Andersen M.E. Physiologically-based pharmacokinetic modeling in the pregnant: A multiroute exposure model for trichloroethylene and its metabolise trichloroacetic acid. Toxicol. Appl. Pharmacol. 99:1989;395-414.
16. Larson J.L., Bull R.J. Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice. Toxicol. Appl. Pharmacol. 115:1992;268-277.
17. Gad S.C., Weil C.S. Statistic for toxicologists. Hayes A.W. Principles and Methods in Toxicology. 1994;221-274 Raven Press, New York, NY.
18. Gonzalez-Leon A., Merdink J.L., Scultz I.R., Bull R.J. Dichloroacetate auto-inhibits its degradation in the cytosol. Toxicol. Sci. 42(1-S):1998;86.
19. Shargel L., Yu A.B.C. Hepatic elimination of drugs. Applied Biopharmaceutics and Pharmacokinetics. 3rd ed:1993;315 Appleton and Lange, Norwalk, CT.
20. Kato-Weinstein J., Lingohr M.K., Orner G.A., Thrall B.D, Bull R.J. Effects of dichloroacete on glycogen metabolism in B6C3F1 mice. Toxicology. 130:1998;141-154.
21. Tong Z., Board P.G., Anders M.W. Glutathione transferase Zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid. Biochem. J. 331:1998;371-374.